Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/arginine-rich splicing factor 5

Gene

Srsf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre-mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity).By similarity

GO - Molecular functioni

  • protein kinase B binding Source: MGI
  • RNA binding Source: MGI
  • RS domain binding Source: MGI

GO - Biological processi

  • mRNA cis splicing, via spliceosome Source: GO_Central
  • positive regulation of RNA splicing Source: MGI
  • regulation of alternative mRNA splicing, via spliceosome Source: GO_Central
  • response to insulin Source: MGI
  • response to wounding Source: MGI

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 5
Alternative name(s):
Delayed-early protein HRS
Pre-mRNA-splicing factor SRP40
Splicing factor, arginine/serine-rich 5
Gene namesi
Name:Srsf5
Synonyms:Hrs, Sfrs5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:98287 Srsf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819281 – 269Serine/arginine-rich splicing factor 5Add BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineBy similarity1
Modified residuei167N6-acetyllysineCombined sources1
Modified residuei224PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei230PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35326
PaxDbiO35326
PeptideAtlasiO35326
PRIDEiO35326

PTM databases

iPTMnetiO35326
PhosphoSitePlusiO35326

Expressioni

Gene expression databases

BgeeiENSMUSG00000021134 Expressed in 57 organ(s), highest expression level in female gonad
ExpressionAtlasiO35326 baseline and differential
GenevisibleiO35326 MM

Interactioni

Subunit structurei

Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (By similarity). Interacts (via RS domain) with PHF5A (via N-terminus).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203190, 4 interactors
DIPiDIP-48724N
IntActiO35326, 1 interactor
STRINGi10090.ENSMUSP00000105981

Structurei

3D structure databases

ProteinModelPortaliO35326
SMRiO35326
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 74RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini108 – 189RRM 2PROSITE-ProRule annotationAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi78 – 83Gly-rich (hinge region)6
Compositional biasi190 – 264Arg/Ser-rich (RS domain)Add BLAST75

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00910000144049
HOGENOMiHOG000276234
HOVERGENiHBG002295
InParanoidiO35326
KOiK12893
OMAiRENDDSH
TreeFamiTF351335

Family and domain databases

CDDicd12337 RRM1_SRSF4_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR035585 RRM1_SRSF4-like
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35326-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGCRVFIGR LNPAAREKDV ERFFKGYGRI RDIDLKRGFG FVEFEDPRDA
60 70 80 90 100
DDAVYELDGK ELCSERVTIE HARARSRGGR GRGRYSDRFS SRRPRNDRRN
110 120 130 140 150
APPVRTENRL IVENLSSRVS WQDLKDFMRQ AGEVTFADAH RPKLNEGVVE
160 170 180 190 200
FASYGDLKNA IEKLSGKEIN GRKIKLIEGS KRHRSRSRSR SRTRSSSRSR
210 220 230 240 250
SRSRSRRSKS YSRSRSRSRS RSKSRSGSRS PVPEKSQKRG SSSRSKSPAS
260
VDRQRSRSRS RSRSVDSGN
Length:269
Mass (Da):30,891
Last modified:October 31, 2012 - v2
Checksum:i0FC90628B64DE845
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D8S5Q9D8S5_MOUSE
MCG7614, isoform CRA_c
Srsf5 Sfrs5, mCG_7614
270Annotation score:
S4R2G3S4R2G3_MOUSE
Serine/arginine-rich-splicing facto...
Srsf5
46Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020308 Genomic DNA Translation: AAC39946.1
AK146624 mRNA Translation: BAE27313.1
AC125092 Genomic DNA No translation available.
CH466590 Genomic DNA Translation: EDL02685.1
CH466590 Genomic DNA Translation: EDL02687.1
CH466590 Genomic DNA Translation: EDL02690.1
CH466590 Genomic DNA Translation: EDL02692.1
CH466590 Genomic DNA Translation: EDL02693.1
BC082593 mRNA Translation: AAH82593.1
CCDSiCCDS36484.1
RefSeqiNP_001073162.1, NM_001079694.2
NP_001073163.1, NM_001079695.2
NP_001334345.1, NM_001347416.1
NP_033185.2, NM_009159.3
UniGeneiMm.43331

Genome annotation databases

EnsembliENSMUST00000094693; ENSMUSP00000131323; ENSMUSG00000021134
ENSMUST00000110352; ENSMUSP00000105981; ENSMUSG00000021134
ENSMUST00000110356; ENSMUSP00000105985; ENSMUSG00000021134
GeneIDi20384
KEGGimmu:20384
UCSCiuc007obo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020308 Genomic DNA Translation: AAC39946.1
AK146624 mRNA Translation: BAE27313.1
AC125092 Genomic DNA No translation available.
CH466590 Genomic DNA Translation: EDL02685.1
CH466590 Genomic DNA Translation: EDL02687.1
CH466590 Genomic DNA Translation: EDL02690.1
CH466590 Genomic DNA Translation: EDL02692.1
CH466590 Genomic DNA Translation: EDL02693.1
BC082593 mRNA Translation: AAH82593.1
CCDSiCCDS36484.1
RefSeqiNP_001073162.1, NM_001079694.2
NP_001073163.1, NM_001079695.2
NP_001334345.1, NM_001347416.1
NP_033185.2, NM_009159.3
UniGeneiMm.43331

3D structure databases

ProteinModelPortaliO35326
SMRiO35326
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203190, 4 interactors
DIPiDIP-48724N
IntActiO35326, 1 interactor
STRINGi10090.ENSMUSP00000105981

PTM databases

iPTMnetiO35326
PhosphoSitePlusiO35326

Proteomic databases

EPDiO35326
PaxDbiO35326
PeptideAtlasiO35326
PRIDEiO35326

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094693; ENSMUSP00000131323; ENSMUSG00000021134
ENSMUST00000110352; ENSMUSP00000105981; ENSMUSG00000021134
ENSMUST00000110356; ENSMUSP00000105985; ENSMUSG00000021134
GeneIDi20384
KEGGimmu:20384
UCSCiuc007obo.1 mouse

Organism-specific databases

CTDi6430
MGIiMGI:98287 Srsf5

Phylogenomic databases

eggNOGiKOG0106 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00910000144049
HOGENOMiHOG000276234
HOVERGENiHBG002295
InParanoidiO35326
KOiK12893
OMAiRENDDSH
TreeFamiTF351335

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing

Miscellaneous databases

ChiTaRSiSrsf5 mouse
PROiPR:O35326
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021134 Expressed in 57 organ(s), highest expression level in female gonad
ExpressionAtlasiO35326 baseline and differential
GenevisibleiO35326 MM

Family and domain databases

CDDicd12337 RRM1_SRSF4_like, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR035585 RRM1_SRSF4-like
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSRSF5_MOUSE
AccessioniPrimary (citable) accession number: O35326
Secondary accession number(s): Q640L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 31, 2012
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again