Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium- and chloride-dependent taurine transporter

Gene

Slc6a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.2 Publications

Kineticsi

  1. KM=4.5 µM for taurine
  2. KM=56 µM for beta-alanine

    GO - Molecular functioni

    GO - Biological processi

    • modulation of chemical synaptic transmission Source: SynGO
    • taurine transport Source: MGI

    Keywordsi

    Biological processNeurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiR-MMU-352230 Amino acid transport across the plasma membrane
    R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent taurine transporter
    Alternative name(s):
    Solute carrier family 6 member 6
    Gene namesi
    Name:Slc6a6
    Synonyms:Taut
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    Proteomesi
    • UP000000589 Componenti: Chromosome 6

    Organism-specific databases

    MGIiMGI:98488 Slc6a6

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
    Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
    Transmembranei123 – 143Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini144 – 215ExtracellularSequence analysisAdd BLAST72
    Transmembranei216 – 236Helical; Name=4Sequence analysisAdd BLAST21
    Transmembranei245 – 265Helical; Name=5Sequence analysisAdd BLAST21
    Transmembranei290 – 310Helical; Name=6Sequence analysisAdd BLAST21
    Transmembranei332 – 352Helical; Name=7Sequence analysisAdd BLAST21
    Transmembranei380 – 400Helical; Name=8Sequence analysisAdd BLAST21
    Transmembranei430 – 450Helical; Name=9Sequence analysisAdd BLAST21
    Transmembranei465 – 485Helical; Name=10Sequence analysisAdd BLAST21
    Transmembranei508 – 528Helical; Name=11Sequence analysisAdd BLAST21
    Transmembranei545 – 565Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini566 – 621CytoplasmicSequence analysisAdd BLAST56

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002147681 – 621Sodium- and chloride-dependent taurine transporterAdd BLAST621

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
    Modified residuei322PhosphoserineBy similarity1

    Post-translational modificationi

    Down-regulated upon Ser-322 phosphorylation.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    EPDiO35316
    PaxDbiO35316
    PeptideAtlasiO35316
    PRIDEiO35316

    PTM databases

    iPTMnetiO35316
    PhosphoSitePlusiO35316
    SwissPalmiO35316

    Expressioni

    Tissue specificityi

    Widely expressed.2 Publications

    Gene expression databases

    BgeeiENSMUSG00000030096 Expressed in 304 organ(s), highest expression level in retina
    ExpressionAtlasiO35316 baseline and differential
    GenevisibleiO35316 MM

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032185

    Structurei

    3D structure databases

    ProteinModelPortaliO35316
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3659 Eukaryota
    COG0733 LUCA
    GeneTreeiENSGT00760000118857
    HOGENOMiHOG000116406
    HOVERGENiHBG071421
    InParanoidiO35316
    KOiK05039
    OMAiDHPGALK
    OrthoDBiEOG091G08PX
    PhylomeDBiO35316
    TreeFamiTF343812

    Family and domain databases

    InterProiView protein in InterPro
    IPR000175 Na/ntran_symport
    IPR002434 Na/ntran_symport_taurine
    IPR037272 SNS_sf
    PANTHERiPTHR11616 PTHR11616, 1 hit
    PfamiView protein in Pfam
    PF00209 SNF, 1 hit
    PRINTSiPR00176 NANEUSMPORT
    PR01200 TAUTRANSPORT
    SUPFAMiSSF161070 SSF161070, 1 hit
    PROSITEiView protein in PROSITE
    PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
    PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
    PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

    Sequence (1+)i

    Sequence statusi: Complete.

    This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

    O35316-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEADGKPPQ REKWSSKIDF
    60 70 80 90 100
    VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEVI
    110 120 130 140 150
    IGQYTSEGGI TCWEKICPLF SGIGYASIVI VSLLNVYYIV ILAWATYYLF
    160 170 180 190 200
    HSFQKDLPWA HCNHSWNTPQ CMEDTLRRNE SHWVSLSTAN FTSPVIEFWE
    210 220 230 240 250
    RNVLSLSSGI DNPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA
    260 270 280 290 300
    TFPFAMLLVL LVRGLTLPGA GEGIKFYLYP DISRLGDPQV WIDAGTQIFF
    310 320 330 340 350
    SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF
    360 370 380 390 400
    MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL
    410 420 430 440 450
    DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAILCSISY LLGLTMVTEG
    460 470 480 490 500
    GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP
    510 520 530 540 550
    GPWMKYSWAV ITPALCVGCF VFSLVKYVPL TYNKVYRYPD WAIGLGWGLA
    560 570 580 590 600
    LSSMLCIPLV IVILLCRTEG PLRVRIKYLI TPREPNRWAV EREGATPFHS
    610 620
    RVTLMNGALM KPSHVIVETM M
    Length:621
    Mass (Da):69,856
    Last modified:November 14, 2003 - v2
    Checksum:i4D3E4ACFDB7D7EA2
    GO

    Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0U1RQA0A0A0U1RQA0_MOUSE
    Transporter
    Slc6a6
    121Annotation score:
    A0A0U1RP20A0A0U1RP20_MOUSE
    Transporter
    Slc6a6
    110Annotation score:
    A0A0U1RQA5A0A0U1RQA5_MOUSE
    Transporter
    Slc6a6
    83Annotation score:
    A0A0U1RPH7A0A0U1RPH7_MOUSE
    Sodium- and chloride-dependent taur...
    Slc6a6
    49Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti340S → L in AAB70922 (PubMed:9375654).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L03292 mRNA Translation: AAB54039.2
    AF020194 mRNA Translation: AAB70922.2
    BC015245 mRNA Translation: AAH15245.1
    CCDSiCCDS39570.1
    PIRiA47194
    RefSeqiNP_033346.2, NM_009320.4
    XP_006505933.1, XM_006505870.1
    XP_006505934.1, XM_006505871.3
    UniGeneiMm.395650

    Genome annotation databases

    EnsembliENSMUST00000032185; ENSMUSP00000032185; ENSMUSG00000030096
    GeneIDi21366
    KEGGimmu:21366
    UCSCiuc009cyh.2 mouse

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L03292 mRNA Translation: AAB54039.2
    AF020194 mRNA Translation: AAB70922.2
    BC015245 mRNA Translation: AAH15245.1
    CCDSiCCDS39570.1
    PIRiA47194
    RefSeqiNP_033346.2, NM_009320.4
    XP_006505933.1, XM_006505870.1
    XP_006505934.1, XM_006505871.3
    UniGeneiMm.395650

    3D structure databases

    ProteinModelPortaliO35316
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032185

    PTM databases

    iPTMnetiO35316
    PhosphoSitePlusiO35316
    SwissPalmiO35316

    Proteomic databases

    EPDiO35316
    PaxDbiO35316
    PeptideAtlasiO35316
    PRIDEiO35316

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000032185; ENSMUSP00000032185; ENSMUSG00000030096
    GeneIDi21366
    KEGGimmu:21366
    UCSCiuc009cyh.2 mouse

    Organism-specific databases

    CTDi6533
    MGIiMGI:98488 Slc6a6

    Phylogenomic databases

    eggNOGiKOG3659 Eukaryota
    COG0733 LUCA
    GeneTreeiENSGT00760000118857
    HOGENOMiHOG000116406
    HOVERGENiHBG071421
    InParanoidiO35316
    KOiK05039
    OMAiDHPGALK
    OrthoDBiEOG091G08PX
    PhylomeDBiO35316
    TreeFamiTF343812

    Enzyme and pathway databases

    ReactomeiR-MMU-352230 Amino acid transport across the plasma membrane
    R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

    Miscellaneous databases

    ChiTaRSiSlc6a6 mouse
    PROiPR:O35316
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSMUSG00000030096 Expressed in 304 organ(s), highest expression level in retina
    ExpressionAtlasiO35316 baseline and differential
    GenevisibleiO35316 MM

    Family and domain databases

    InterProiView protein in InterPro
    IPR000175 Na/ntran_symport
    IPR002434 Na/ntran_symport_taurine
    IPR037272 SNS_sf
    PANTHERiPTHR11616 PTHR11616, 1 hit
    PfamiView protein in Pfam
    PF00209 SNF, 1 hit
    PRINTSiPR00176 NANEUSMPORT
    PR01200 TAUTRANSPORT
    SUPFAMiSSF161070 SSF161070, 1 hit
    PROSITEiView protein in PROSITE
    PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
    PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
    PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSC6A6_MOUSE
    AccessioniPrimary (citable) accession number: O35316
    Secondary accession number(s): P31642, Q91WI2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 14, 2003
    Last modified: November 7, 2018
    This is version 140 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again