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Protein

Monocarboxylate transporter 3

Gene

Slc16a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-210991 Basigin interactions
R-MMU-433692 Proton-coupled monocarboxylate transport
R-MMU-70268 Pyruvate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 3
Short name:
MCT 3
Alternative name(s):
Proton-coupled monocarboxylate transporter 3
Solute carrier family 16 member 8
Gene namesi
Name:Slc16a8
Synonyms:Mct3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1929519 Slc16a8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 58ExtracellularSequence analysisAdd BLAST23
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 85CytoplasmicSequence analysis6
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 115ExtracellularSequence analysis9
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 146CytoplasmicSequence analysis10
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 172ExtracellularSequence analysis5
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 228CytoplasmicSequence analysisAdd BLAST35
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 257ExtracellularSequence analysis8
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 293CytoplasmicSequence analysisAdd BLAST15
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 318ExtracellularSequence analysis4
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 352CytoplasmicSequence analysisAdd BLAST13
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 386ExtracellularSequence analysisAdd BLAST13
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 492CytoplasmicSequence analysisAdd BLAST85

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113911 – 492Monocarboxylate transporter 3Add BLAST492

Proteomic databases

PaxDbiO35308
PRIDEiO35308

PTM databases

iPTMnetiO35308
PhosphoSitePlusiO35308

Expressioni

Tissue specificityi

Retinal pigment epithelium.

Gene expression databases

BgeeiENSMUSG00000032988 Expressed in 40 organ(s), highest expression level in camera-type eye
ExpressionAtlasiO35308 baseline and differential
GenevisibleiO35308 MM

Structurei

3D structure databases

ProteinModelPortaliO35308
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMU2 Eukaryota
ENOG410ZJAI LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO35308
KOiK08185
OMAiCTDRAFA
OrthoDBiEOG091G05SW
PhylomeDBiO35308
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR030759 MCT3
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF26 PTHR11360:SF26, 2 hits
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

O35308-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGGPRRGA GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRELKRDF
60 70 80 90 100
GAGYSDTAWV SSIMLAMLYG TGPLSSILVT RFGCRPVMLA GGLLASAGMI
110 120 130 140 150
LASFASRLVE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA
160 170 180 190 200
AGSPVFLSML SPLGQLLGER FGWRGGFLLF GGLLLHCCAC GAVMRPPPGP
210 220 230 240 250
PPRRDPSPHG GPARRRRLLD VAVCTDRAFV VYVVTKFLMA LGLFVPAILL
260 270 280 290 300
VNYAKDAGVP DAEAAFLLSI VGFVDIVARP ACGALAGLGR LRPHVPYLFS
310 320 330 340 350
LALLANGLTD LISARARSYG TLVAFCIAFG LSYGMVGALQ FEVLMATVGA
360 370 380 390 400
PRFPSALGLV LLVEAVAVLI GPPSAGRLVD ALKNYEIIFY LAGSEVALAG
410 420 430 440 450
VFMAVTTYCC LRCSKNISSG RSAEGGASDP EDVEAERDSE PMPASTEEPG
460 470 480 490
SLEALEVLSP RAGSPEQEPE EEAVPELDHE SIGGHEARGQ KA
Length:492
Mass (Da):51,556
Last modified:October 1, 2000 - v2
Checksum:i2B19E362B96D9ACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019111 mRNA Translation: AAB70582.2
AF178956 Genomic DNA Translation: AAF45042.1
BC018216 mRNA Translation: AAH18216.1
CCDSiCCDS27636.1
RefSeqiNP_065262.1, NM_020516.2
XP_017172202.1, XM_017316713.1
UniGeneiMm.441697

Genome annotation databases

EnsembliENSMUST00000039752; ENSMUSP00000040522; ENSMUSG00000032988
GeneIDi57274
KEGGimmu:57274
UCSCiuc007wta.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019111 mRNA Translation: AAB70582.2
AF178956 Genomic DNA Translation: AAF45042.1
BC018216 mRNA Translation: AAH18216.1
CCDSiCCDS27636.1
RefSeqiNP_065262.1, NM_020516.2
XP_017172202.1, XM_017316713.1
UniGeneiMm.441697

3D structure databases

ProteinModelPortaliO35308
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO35308
PhosphoSitePlusiO35308

Proteomic databases

PaxDbiO35308
PRIDEiO35308

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039752; ENSMUSP00000040522; ENSMUSG00000032988
GeneIDi57274
KEGGimmu:57274
UCSCiuc007wta.1 mouse

Organism-specific databases

CTDi23539
MGIiMGI:1929519 Slc16a8

Phylogenomic databases

eggNOGiENOG410IMU2 Eukaryota
ENOG410ZJAI LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO35308
KOiK08185
OMAiCTDRAFA
OrthoDBiEOG091G05SW
PhylomeDBiO35308
TreeFamiTF313792

Enzyme and pathway databases

ReactomeiR-MMU-210991 Basigin interactions
R-MMU-433692 Proton-coupled monocarboxylate transport
R-MMU-70268 Pyruvate metabolism

Miscellaneous databases

PROiPR:O35308
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032988 Expressed in 40 organ(s), highest expression level in camera-type eye
ExpressionAtlasiO35308 baseline and differential
GenevisibleiO35308 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR030759 MCT3
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF26 PTHR11360:SF26, 2 hits
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOT3_MOUSE
AccessioniPrimary (citable) accession number: O35308
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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