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Protein

Monocarboxylate transporter 3

Gene

Slc16a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-210991 Basigin interactions
R-MMU-433692 Proton-coupled monocarboxylate transport
R-MMU-70268 Pyruvate metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Monocarboxylate transporter 3
Short name:
MCT 3
Alternative name(s):
Proton-coupled monocarboxylate transporter 3
Solute carrier family 16 member 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc16a8
Synonyms:Mct3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1929519 Slc16a8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 58ExtracellularSequence analysisAdd BLAST23
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 85CytoplasmicSequence analysis6
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 115ExtracellularSequence analysis9
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 146CytoplasmicSequence analysis10
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 172ExtracellularSequence analysis5
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 228CytoplasmicSequence analysisAdd BLAST35
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 257ExtracellularSequence analysis8
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 293CytoplasmicSequence analysisAdd BLAST15
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 318ExtracellularSequence analysis4
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 352CytoplasmicSequence analysisAdd BLAST13
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 386ExtracellularSequence analysisAdd BLAST13
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 492CytoplasmicSequence analysisAdd BLAST85

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002113911 – 492Monocarboxylate transporter 3Add BLAST492

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O35308

PRoteomics IDEntifications database

More...
PRIDEi
O35308

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O35308

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O35308

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Retinal pigment epithelium.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032988 Expressed in 40 organ(s), highest expression level in camera-type eye

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O35308 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O35308 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O35308

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMU2 Eukaryota
ENOG410ZJAI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161934

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000280688

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006384

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O35308

KEGG Orthology (KO)

More...
KOi
K08185

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTDRAFA

Database of Orthologous Groups

More...
OrthoDBi
916876at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O35308

TreeFam database of animal gene trees

More...
TreeFami
TF313792

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004743 MCT
IPR030759 MCT3
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11360:SF26 PTHR11360:SF26, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690 MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00892 2A0113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O35308-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGGPRRGA GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRELKRDF
60 70 80 90 100
GAGYSDTAWV SSIMLAMLYG TGPLSSILVT RFGCRPVMLA GGLLASAGMI
110 120 130 140 150
LASFASRLVE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA
160 170 180 190 200
AGSPVFLSML SPLGQLLGER FGWRGGFLLF GGLLLHCCAC GAVMRPPPGP
210 220 230 240 250
PPRRDPSPHG GPARRRRLLD VAVCTDRAFV VYVVTKFLMA LGLFVPAILL
260 270 280 290 300
VNYAKDAGVP DAEAAFLLSI VGFVDIVARP ACGALAGLGR LRPHVPYLFS
310 320 330 340 350
LALLANGLTD LISARARSYG TLVAFCIAFG LSYGMVGALQ FEVLMATVGA
360 370 380 390 400
PRFPSALGLV LLVEAVAVLI GPPSAGRLVD ALKNYEIIFY LAGSEVALAG
410 420 430 440 450
VFMAVTTYCC LRCSKNISSG RSAEGGASDP EDVEAERDSE PMPASTEEPG
460 470 480 490
SLEALEVLSP RAGSPEQEPE EEAVPELDHE SIGGHEARGQ KA
Length:492
Mass (Da):51,556
Last modified:October 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B19E362B96D9ACC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF019111 mRNA Translation: AAB70582.2
AF178956 Genomic DNA Translation: AAF45042.1
BC018216 mRNA Translation: AAH18216.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27636.1

NCBI Reference Sequences

More...
RefSeqi
NP_065262.1, NM_020516.2
XP_017172202.1, XM_017316713.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.441697

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000039752; ENSMUSP00000040522; ENSMUSG00000032988

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:57274

UCSC genome browser

More...
UCSCi
uc007wta.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019111 mRNA Translation: AAB70582.2
AF178956 Genomic DNA Translation: AAF45042.1
BC018216 mRNA Translation: AAH18216.1
CCDSiCCDS27636.1
RefSeqiNP_065262.1, NM_020516.2
XP_017172202.1, XM_017316713.1
UniGeneiMm.441697

3D structure databases

ProteinModelPortaliO35308
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO35308
PhosphoSitePlusiO35308

Proteomic databases

PaxDbiO35308
PRIDEiO35308

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039752; ENSMUSP00000040522; ENSMUSG00000032988
GeneIDi57274
KEGGimmu:57274
UCSCiuc007wta.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23539
MGIiMGI:1929519 Slc16a8

Phylogenomic databases

eggNOGiENOG410IMU2 Eukaryota
ENOG410ZJAI LUCA
GeneTreeiENSGT00940000161934
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO35308
KOiK08185
OMAiCTDRAFA
OrthoDBi916876at2759
PhylomeDBiO35308
TreeFamiTF313792

Enzyme and pathway databases

ReactomeiR-MMU-210991 Basigin interactions
R-MMU-433692 Proton-coupled monocarboxylate transport
R-MMU-70268 Pyruvate metabolism

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O35308

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032988 Expressed in 40 organ(s), highest expression level in camera-type eye
ExpressionAtlasiO35308 baseline and differential
GenevisibleiO35308 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR030759 MCT3
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF26 PTHR11360:SF26, 2 hits
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOT3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35308
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: January 16, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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