Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor receptor superfamily member 11A

Gene

Tnfrsf11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi134Sodium; via carbonyl oxygen1
Metal bindingi135Sodium; via carbonyl oxygen1
Metal bindingi138Sodium; via carbonyl oxygen1
Metal bindingi161Sodium; via carbonyl oxygen1
Metal bindingi163Sodium; via carbonyl oxygen1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandMetal-binding, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11A
Alternative name(s):
Osteoclast differentiation factor receptor
Short name:
ODFR
Receptor activator of NF-KB
CD_antigen: CD265
Gene namesi
Name:Tnfrsf11a
Synonyms:Rank
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1314891 Tnfrsf11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 214ExtracellularSequence analysisAdd BLAST184
Transmembranei215 – 234HelicalSequence analysisAdd BLAST20
Topological domaini235 – 625CytoplasmicSequence analysisAdd BLAST391

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000003458631 – 625Tumor necrosis factor receptor superfamily member 11AAdd BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 47
Disulfide bondi48 ↔ 61
Disulfide bondi51 ↔ 69
Disulfide bondi72 ↔ 87
Disulfide bondi93 ↔ 113
Glycosylationi106N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi115 ↔ 128
Disulfide bondi125 ↔ 127
Disulfide bondi134 ↔ 152
Disulfide bondi155 ↔ 170
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi176 ↔ 195
Modified residuei571PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO35305
PaxDbiO35305
PeptideAtlasiO35305
PRIDEiO35305

PTM databases

iPTMnetiO35305
PhosphoSitePlusiO35305

Expressioni

Tissue specificityi

Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.

Gene expression databases

BgeeiENSMUSG00000026321 Expressed in 112 organ(s), highest expression level in submandibular gland
GenevisibleiO35305 MM

Interactioni

Subunit structurei

Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 (By similarity). Interacts (via cytoplasmic domain) with GAB2 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204246, 4 interactors
DIPiDIP-48710N
ELMiO35305
IntActiO35305, 11 interactors
MINTiO35305
STRINGi10090.ENSMUSP00000027559

Structurei

Secondary structure

1625
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO35305
SMRiO35305
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35305

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 69TNFR-Cys 1Add BLAST35
Repeati72 – 113TNFR-Cys 2Add BLAST42
Repeati115 – 152TNFR-Cys 3Add BLAST38
Repeati155 – 195TNFR-Cys 4Add BLAST41

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHUN Eukaryota
ENOG41125ED LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000154659
HOVERGENiHBG079274
InParanoidiO35305
KOiK05147
OMAiCRRNAEC
OrthoDBiEOG091G03XW
PhylomeDBiO35305
TreeFamiTF331157

Family and domain databases

CDDicd13411 TNFRSF11A, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022323 TNFR_11
IPR022361 TNFR_11A
IPR034040 TNFRSF11A_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01961 TNFACTORR11
PR01974 TNFACTORR11A
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35305-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPRARRRRQ LPAPLLALCV LLVPLQVTLQ VTPPCTQERH YEHLGRCCSR
60 70 80 90 100
CEPGKYLSSK CTPTSDSVCL PCGPDEYLDT WNEEDKCLLH KVCDAGKALV
110 120 130 140 150
AVDPGNHTAP RRCACTAGYH WNSDCECCRR NTECAPGFGA QHPLQLNKDT
160 170 180 190 200
VCTPCLLGFF SDVFSSTDKC KPWTNCTLLG KLEAHQGTTE SDVVCSSSMT
210 220 230 240 250
LRRPPKEAQA YLPSLIVLLL FISVVVVAAI IFGVYYRKGG KALTANLWNW
260 270 280 290 300
VNDACSSLSG NKESSGDRCA GSHSATSSQQ EVCEGILLMT REEKMVPEDG
310 320 330 340 350
AGVCGPVCAA GGPWAEVRDS RTFTLVSEVE TQGDLSRKIP TEDEYTDRPS
360 370 380 390 400
QPSTGSLLLI QQGSKSIPPF QEPLEVGEND SLSQCFTGTE STVDSEGCDF
410 420 430 440 450
TEPPSRTDSM PVSPEKHLTK EIEGDSCLPW VVSSNSTDGY TGSGNTPGED
460 470 480 490 500
HEPFPGSLKC GPLPQCAYSM GFPSEAAASM AEAGVRPQDR ADERGASGSG
510 520 530 540 550
SSPSDQPPAS GNVTGNSNST FISSGQVMNF KGDIIVVYVS QTSQEGPGSA
560 570 580 590 600
EPESEPVGRP VQEETLAHRD SFAGTAPRFP DVCATGAGLQ EQGAPRQKDG
610 620
TSRPVQEQGG AQTSLHTQGS GQCAE
Length:625
Mass (Da):66,621
Last modified:January 1, 1998 - v1
Checksum:iF8C1872E99511D8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti494R → K in AAH19185 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019046 mRNA Translation: AAB86810.1
BC019185 mRNA Translation: AAH19185.1
CCDSiCCDS15207.1
RefSeqiNP_033425.3, NM_009399.3
UniGeneiMm.6251

Genome annotation databases

EnsembliENSMUST00000027559; ENSMUSP00000027559; ENSMUSG00000026321
GeneIDi21934
KEGGimmu:21934
UCSCiuc007cgp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019046 mRNA Translation: AAB86810.1
BC019185 mRNA Translation: AAH19185.1
CCDSiCCDS15207.1
RefSeqiNP_033425.3, NM_009399.3
UniGeneiMm.6251

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ME2X-ray2.80R26-210[»]
3ME4X-ray2.01A/B26-210[»]
3QBQX-ray2.50B/D32-201[»]
4GIQX-ray2.70R31-198[»]
5BNQX-ray2.80R26-210[»]
ProteinModelPortaliO35305
SMRiO35305
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204246, 4 interactors
DIPiDIP-48710N
ELMiO35305
IntActiO35305, 11 interactors
MINTiO35305
STRINGi10090.ENSMUSP00000027559

PTM databases

iPTMnetiO35305
PhosphoSitePlusiO35305

Proteomic databases

MaxQBiO35305
PaxDbiO35305
PeptideAtlasiO35305
PRIDEiO35305

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027559; ENSMUSP00000027559; ENSMUSG00000026321
GeneIDi21934
KEGGimmu:21934
UCSCiuc007cgp.1 mouse

Organism-specific databases

CTDi8792
MGIiMGI:1314891 Tnfrsf11a

Phylogenomic databases

eggNOGiENOG410IHUN Eukaryota
ENOG41125ED LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000154659
HOVERGENiHBG079274
InParanoidiO35305
KOiK05147
OMAiCRRNAEC
OrthoDBiEOG091G03XW
PhylomeDBiO35305
TreeFamiTF331157

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Miscellaneous databases

ChiTaRSiTnfrsf11a mouse
EvolutionaryTraceiO35305
PROiPR:O35305
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026321 Expressed in 112 organ(s), highest expression level in submandibular gland
GenevisibleiO35305 MM

Family and domain databases

CDDicd13411 TNFRSF11A, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022323 TNFR_11
IPR022361 TNFR_11A
IPR034040 TNFRSF11A_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01961 TNFACTORR11
PR01974 TNFACTORR11A
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNR11_MOUSE
AccessioniPrimary (citable) accession number: O35305
Secondary accession number(s): Q8VCT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again