UniProtKB - O35305 (TNR11_MOUSE)
Protein
Tumor necrosis factor receptor superfamily member 11A
Gene
Tnfrsf11a
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 134 | Sodium; via carbonyl oxygen | 1 | |
Metal bindingi | 135 | Sodium; via carbonyl oxygen | 1 | |
Metal bindingi | 138 | Sodium; via carbonyl oxygen | 1 | |
Metal bindingi | 161 | Sodium; via carbonyl oxygen | 1 | |
Metal bindingi | 163 | Sodium; via carbonyl oxygen | 1 |
GO - Molecular functioni
- cytokine binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- transmembrane signaling receptor activity Source: MGI
- tumor necrosis factor-activated receptor activity Source: BHF-UCL
GO - Biological processi
- adaptive immune response Source: MGI
- circadian temperature homeostasis Source: BHF-UCL
- lymph node development Source: MGI
- mammary gland alveolus development Source: MGI
- multicellular organism development Source: MGI
- multinuclear osteoclast differentiation Source: MGI
- ossification Source: MGI
- osteoclast differentiation Source: MGI
- positive regulation of bone resorption Source: MGI
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling Source: MGI
- positive regulation of fever generation by positive regulation of prostaglandin secretion Source: BHF-UCL
- positive regulation of JUN kinase activity Source: MGI
- positive regulation of NF-kappaB transcription factor activity Source: MGI
- response to cytokine Source: MGI
- response to interleukin-1 Source: BHF-UCL
- response to lipopolysaccharide Source: BHF-UCL
- response to radiation Source: Ensembl
- response to tumor necrosis factor Source: BHF-UCL
- TNFSF11-mediated signaling pathway Source: MGI
- tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | Receptor |
Ligand | Metal-binding, Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 11AAlternative name(s): Osteoclast differentiation factor receptor Short name: ODFR Receptor activator of NF-KB CD_antigen: CD265 |
Gene namesi | Name:Tnfrsf11a Synonyms:Rank |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1314891, Tnfrsf11a |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Curated
Cytosol
- cytosol Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 214 | ExtracellularSequence analysisAdd BLAST | 184 | |
Transmembranei | 215 – 234 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 235 – 625 | CytoplasmicSequence analysisAdd BLAST | 391 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000034586 | 31 – 625 | Tumor necrosis factor receptor superfamily member 11AAdd BLAST | 595 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 47 | |||
Disulfide bondi | 48 ↔ 61 | |||
Disulfide bondi | 51 ↔ 69 | |||
Disulfide bondi | 72 ↔ 87 | |||
Disulfide bondi | 93 ↔ 113 | |||
Glycosylationi | 106 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 115 ↔ 128 | |||
Disulfide bondi | 125 ↔ 127 | |||
Disulfide bondi | 134 ↔ 152 | |||
Disulfide bondi | 155 ↔ 170 | |||
Glycosylationi | 175 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 176 ↔ 195 | |||
Modified residuei | 571 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | O35305 |
PaxDbi | O35305 |
PeptideAtlasi | O35305 |
PRIDEi | O35305 |
PTM databases
GlyGeni | O35305, 2 sites |
iPTMneti | O35305 |
PhosphoSitePlusi | O35305 |
Expressioni
Tissue specificityi
Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.
Gene expression databases
Bgeei | ENSMUSG00000026321, Expressed in submandibular gland and 136 other tissues |
Genevisiblei | O35305, MM |
Interactioni
Subunit structurei
Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer.
Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 (By similarity).
Interacts (via cytoplasmic domain) with GAB2 (By similarity).
By similarityBinary interactionsi
Hide detailsO35305
GO - Molecular functioni
- cytokine binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204246, 4 interactors |
DIPi | DIP-48710N |
ELMi | O35305 |
IntActi | O35305, 11 interactors |
MINTi | O35305 |
STRINGi | 10090.ENSMUSP00000027559 |
Miscellaneous databases
RNActi | O35305, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O35305 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O35305 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 35 – 69 | TNFR-Cys 1Add BLAST | 35 | |
Repeati | 72 – 113 | TNFR-Cys 2Add BLAST | 42 | |
Repeati | 115 – 152 | TNFR-Cys 3Add BLAST | 38 | |
Repeati | 155 – 195 | TNFR-Cys 4Add BLAST | 41 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RWJI, Eukaryota |
GeneTreei | ENSGT00940000161211 |
HOGENOMi | CLU_026571_0_0_1 |
InParanoidi | O35305 |
OMAi | FRGWITC |
OrthoDBi | 1038336at2759 |
PhylomeDBi | O35305 |
TreeFami | TF331157 |
Family and domain databases
CDDi | cd13411, TNFRSF11A, 1 hit |
InterProi | View protein in InterPro IPR041648, RANK_CRD_2 IPR001368, TNFR/NGFR_Cys_rich_reg IPR022323, TNFR_11 IPR022361, TNFR_11A IPR034040, TNFRSF11A_N |
Pfami | View protein in Pfam PF18278, RANK_CRD_2, 1 hit PF00020, TNFR_c6, 1 hit |
PRINTSi | PR01961, TNFACTORR11 PR01974, TNFACTORR11A |
SMARTi | View protein in SMART SM00208, TNFR, 4 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 1 hit PS50050, TNFR_NGFR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O35305-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPRARRRRQ LPAPLLALCV LLVPLQVTLQ VTPPCTQERH YEHLGRCCSR
60 70 80 90 100
CEPGKYLSSK CTPTSDSVCL PCGPDEYLDT WNEEDKCLLH KVCDAGKALV
110 120 130 140 150
AVDPGNHTAP RRCACTAGYH WNSDCECCRR NTECAPGFGA QHPLQLNKDT
160 170 180 190 200
VCTPCLLGFF SDVFSSTDKC KPWTNCTLLG KLEAHQGTTE SDVVCSSSMT
210 220 230 240 250
LRRPPKEAQA YLPSLIVLLL FISVVVVAAI IFGVYYRKGG KALTANLWNW
260 270 280 290 300
VNDACSSLSG NKESSGDRCA GSHSATSSQQ EVCEGILLMT REEKMVPEDG
310 320 330 340 350
AGVCGPVCAA GGPWAEVRDS RTFTLVSEVE TQGDLSRKIP TEDEYTDRPS
360 370 380 390 400
QPSTGSLLLI QQGSKSIPPF QEPLEVGEND SLSQCFTGTE STVDSEGCDF
410 420 430 440 450
TEPPSRTDSM PVSPEKHLTK EIEGDSCLPW VVSSNSTDGY TGSGNTPGED
460 470 480 490 500
HEPFPGSLKC GPLPQCAYSM GFPSEAAASM AEAGVRPQDR ADERGASGSG
510 520 530 540 550
SSPSDQPPAS GNVTGNSNST FISSGQVMNF KGDIIVVYVS QTSQEGPGSA
560 570 580 590 600
EPESEPVGRP VQEETLAHRD SFAGTAPRFP DVCATGAGLQ EQGAPRQKDG
610 620
TSRPVQEQGG AQTSLHTQGS GQCAE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 494 | R → K in AAH19185 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019046 mRNA Translation: AAB86810.1 BC019185 mRNA Translation: AAH19185.1 |
CCDSi | CCDS15207.1 |
RefSeqi | NP_033425.3, NM_009399.3 |
Genome annotation databases
Ensembli | ENSMUST00000027559; ENSMUSP00000027559; ENSMUSG00000026321 |
GeneIDi | 21934 |
KEGGi | mmu:21934 |
UCSCi | uc007cgp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019046 mRNA Translation: AAB86810.1 BC019185 mRNA Translation: AAH19185.1 |
CCDSi | CCDS15207.1 |
RefSeqi | NP_033425.3, NM_009399.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ME2 | X-ray | 2.80 | R | 26-210 | [»] | |
3ME4 | X-ray | 2.01 | A/B | 26-210 | [»] | |
3QBQ | X-ray | 2.50 | B/D | 32-201 | [»] | |
4GIQ | X-ray | 2.70 | R | 31-198 | [»] | |
5BNQ | X-ray | 2.80 | R | 26-210 | [»] | |
SMRi | O35305 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204246, 4 interactors |
DIPi | DIP-48710N |
ELMi | O35305 |
IntActi | O35305, 11 interactors |
MINTi | O35305 |
STRINGi | 10090.ENSMUSP00000027559 |
PTM databases
GlyGeni | O35305, 2 sites |
iPTMneti | O35305 |
PhosphoSitePlusi | O35305 |
Proteomic databases
MaxQBi | O35305 |
PaxDbi | O35305 |
PeptideAtlasi | O35305 |
PRIDEi | O35305 |
Protocols and materials databases
Antibodypediai | 4165, 741 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027559; ENSMUSP00000027559; ENSMUSG00000026321 |
GeneIDi | 21934 |
KEGGi | mmu:21934 |
UCSCi | uc007cgp.1, mouse |
Organism-specific databases
CTDi | 8792 |
MGIi | MGI:1314891, Tnfrsf11a |
Phylogenomic databases
eggNOGi | ENOG502RWJI, Eukaryota |
GeneTreei | ENSGT00940000161211 |
HOGENOMi | CLU_026571_0_0_1 |
InParanoidi | O35305 |
OMAi | FRGWITC |
OrthoDBi | 1038336at2759 |
PhylomeDBi | O35305 |
TreeFami | TF331157 |
Enzyme and pathway databases
Reactomei | R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
Miscellaneous databases
BioGRID-ORCSi | 21934, 0 hits in 17 CRISPR screens |
ChiTaRSi | Tnfrsf11a, mouse |
EvolutionaryTracei | O35305 |
PROi | PR:O35305 |
RNActi | O35305, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026321, Expressed in submandibular gland and 136 other tissues |
Genevisiblei | O35305, MM |
Family and domain databases
CDDi | cd13411, TNFRSF11A, 1 hit |
InterProi | View protein in InterPro IPR041648, RANK_CRD_2 IPR001368, TNFR/NGFR_Cys_rich_reg IPR022323, TNFR_11 IPR022361, TNFR_11A IPR034040, TNFRSF11A_N |
Pfami | View protein in Pfam PF18278, RANK_CRD_2, 1 hit PF00020, TNFR_c6, 1 hit |
PRINTSi | PR01961, TNFACTORR11 PR01974, TNFACTORR11A |
SMARTi | View protein in SMART SM00208, TNFR, 4 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 1 hit PS50050, TNFR_NGFR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR11_MOUSE | |
Accessioni | O35305Primary (citable) accession number: O35305 Secondary accession number(s): Q8VCT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references