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Protein

Exocyst complex component 7

Gene

Exoc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion.1 Publication

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 7
Alternative name(s):
Exocyst complex component Exo70
Gene namesi
Name:Exoc7
Synonyms:Exo70
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1859270 Exoc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189611 – 697Exocyst complex component 7Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35250
PeptideAtlasiO35250
PRIDEiO35250

PTM databases

iPTMnetiO35250
PhosphoSitePlusiO35250

Expressioni

Gene expression databases

BgeeiENSMUSG00000020792 Expressed in 288 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_EXOC7
ExpressionAtlasiO35250 baseline and differential
GenevisibleiO35250 MM

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with RAB11FIP3 (By similarity). Interacts with ARHQ in a GTP-dependent manner.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Exoc4O353822EBI-775332,EBI-772648

Protein-protein interaction databases

IntActiO35250, 8 interactors
MINTiO35250
STRINGi10090.ENSMUSP00000021147

Structurei

Secondary structure

1697
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO35250
SMRiO35250
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35250

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 384SEC8 and ARHQ bindingAdd BLAST384

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 42Sequence analysisAdd BLAST38
Coiled coili63 – 85Sequence analysisAdd BLAST23

Domaini

The C-terminus is required for translocation to the plasma membrane.

Sequence similaritiesi

Belongs to the EXO70 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2344 Eukaryota
ENOG410YIGI LUCA
GeneTreeiENSGT00390000003595
HOGENOMiHOG000231194
HOVERGENiHBG051515
InParanoidiO35250
KOiK07195
OMAiKDRVDKY
OrthoDBiEOG091G02QC
PhylomeDBiO35250
TreeFamiTF324243

Family and domain databases

InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR004140 Exo70
PANTHERiPTHR12542 PTHR12542, 1 hit
PfamiView protein in Pfam
PF03081 Exo70, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O35250-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTR NMVSILSSFE
60 70 80 90 100
SRLMKLENSI IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI
110 120 130 140 150
IREGPTGRLE EYLGSMAKIQ KAVEYFQDNS PDSPELNKVK LLFERGKESL
160 170 180 190 200
ESEFRSLMTR HSKVVSPVLL LDLISADDEL EVQEDVVLEH LPESVLRDVV
210 220 230 240 250
RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFRK SSSSSGVPYS
260 270 280 290 300
PAIPNKRKDT PTKKPIKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE
310 320 330 340 350
GRDDMLDVET DAYIHCVSAF VKLAQSEYRL LMEIIPEHHQ KKTFDSLIQD
360 370 380 390 400
ALDGLMLEGE NIVSAARKAI IRHDFSTVLT VFPILRHLKQ TKPEFDQVLQ
410 420 430 440 450
GTAASTKNKL PGLITSMETI GAKALEDFAD NIKNDPDKEY NMPKDGTVHE
460 470 480 490 500
LTSNAILFLQ QLLDFQETAG AMLASQVLGD TYNIPLDPRE TSSSATSYSS
510 520 530 540 550
EFSKRLLSTY ICKVLGNLQL NLLSKSKVYE DPALSAIFLH NNYNYILKSL
560 570 580 590 600
EKSELIQLVA VTQKTAERSY REHIEQQIQT YQRSWLKVTD YIAEKNLPVF
610 620 630 640 650
QPGVKLRDKE RQMIKERFKG FNDGLEELCK IQKVWAIPDT EQRDKIRQAQ
660 670 680 690
KDIVKETYGA FLHRYGSVPF TKNPEKYIKY RVEQVGDMID RLFDTSA
Length:697
Mass (Da):79,960
Last modified:December 6, 2002 - v2
Checksum:i0A78F00E1D5D575A
GO
Isoform 2 (identifier: O35250-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-300: Missing.
     477-489: Missing.

Show »
Length:653
Mass (Da):75,159
Checksum:i40BB7E7298E82D53
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AAN0A2AAN0_MOUSE
Exocyst complex component 7
Exoc7
684Annotation score:
A2AAN3A2AAN3_MOUSE
Exocyst complex component 7
Exoc7
288Annotation score:
A2AAN4A2AAN4_MOUSE
Exocyst complex component 7
Exoc7
105Annotation score:
A2AAN5A2AAN5_MOUSE
Exocyst complex component 7
Exoc7
60Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40R → K in AAB69345 (Ref. 1) Curated1
Sequence conflicti165V → I in AAB69345 (Ref. 1) Curated1
Sequence conflicti433K → E in AAB69345 (Ref. 1) Curated1
Sequence conflicti529Y → F in AAB69345 (Ref. 1) Curated1
Sequence conflicti610 – 611ER → DP in AAB69345 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001484270 – 300Missing in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_001485477 – 489Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014461 mRNA Translation: AAB69345.1
BC028927 mRNA Translation: AAH28927.1
CCDSiCCDS25664.1 [O35250-1]
CCDS48983.1 [O35250-2]
PIRiT03722
RefSeqiNP_001156344.1, NM_001162872.1 [O35250-2]
NP_058553.2, NM_016857.2 [O35250-1]
UniGeneiMm.22530

Genome annotation databases

EnsembliENSMUST00000021147; ENSMUSP00000021147; ENSMUSG00000020792 [O35250-1]
ENSMUST00000106411; ENSMUSP00000102019; ENSMUSG00000020792 [O35250-2]
GeneIDi53413
KEGGimmu:53413
UCSCiuc007mks.2 mouse [O35250-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014461 mRNA Translation: AAB69345.1
BC028927 mRNA Translation: AAH28927.1
CCDSiCCDS25664.1 [O35250-1]
CCDS48983.1 [O35250-2]
PIRiT03722
RefSeqiNP_001156344.1, NM_001162872.1 [O35250-2]
NP_058553.2, NM_016857.2 [O35250-1]
UniGeneiMm.22530

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PFTX-ray2.25A85-697[»]
ProteinModelPortaliO35250
SMRiO35250
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35250, 8 interactors
MINTiO35250
STRINGi10090.ENSMUSP00000021147

PTM databases

iPTMnetiO35250
PhosphoSitePlusiO35250

Proteomic databases

PaxDbiO35250
PeptideAtlasiO35250
PRIDEiO35250

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021147; ENSMUSP00000021147; ENSMUSG00000020792 [O35250-1]
ENSMUST00000106411; ENSMUSP00000102019; ENSMUSG00000020792 [O35250-2]
GeneIDi53413
KEGGimmu:53413
UCSCiuc007mks.2 mouse [O35250-1]

Organism-specific databases

CTDi23265
MGIiMGI:1859270 Exoc7

Phylogenomic databases

eggNOGiKOG2344 Eukaryota
ENOG410YIGI LUCA
GeneTreeiENSGT00390000003595
HOGENOMiHOG000231194
HOVERGENiHBG051515
InParanoidiO35250
KOiK07195
OMAiKDRVDKY
OrthoDBiEOG091G02QC
PhylomeDBiO35250
TreeFamiTF324243

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRSiExoc7 mouse
EvolutionaryTraceiO35250
PROiPR:O35250
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020792 Expressed in 288 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_EXOC7
ExpressionAtlasiO35250 baseline and differential
GenevisibleiO35250 MM

Family and domain databases

InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR004140 Exo70
PANTHERiPTHR12542 PTHR12542, 1 hit
PfamiView protein in Pfam
PF03081 Exo70, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC7_MOUSE
AccessioniPrimary (citable) accession number: O35250
Secondary accession number(s): Q8K121
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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