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Protein

Protein FAN

Gene

Nsmaf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.

GO - Molecular functioni

  • death receptor binding Source: MGI
  • sphingomyelin phosphodiesterase activator activity Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5626978 TNFR1-mediated ceramide production

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAN
Alternative name(s):
Factor associated with neutral sphingomyelinase activation
Short name:
Factor associated with N-SMase activation
Gene namesi
Name:Nsmaf
Synonyms:Fan
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1341864 Nsmaf

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509761 – 920Protein FANAdd BLAST920

Proteomic databases

EPDiO35242
MaxQBiO35242
PaxDbiO35242
PeptideAtlasiO35242
PRIDEiO35242

PTM databases

iPTMnetiO35242
PhosphoSitePlusiO35242

Expressioni

Gene expression databases

BgeeiENSMUSG00000028245 Expressed in 288 organ(s), highest expression level in female gonad
ExpressionAtlasiO35242 baseline and differential
GenevisibleiO35242 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029910

Structurei

3D structure databases

ProteinModelPortaliO35242
SMRiO35242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 247GRAMAdd BLAST72
Domaini189 – 286BEACH-type PHPROSITE-ProRule annotationAdd BLAST98
Domaini290 – 575BEACHPROSITE-ProRule annotationAdd BLAST286
Repeati631 – 661WD 1Add BLAST31
Repeati673 – 703WD 2Add BLAST31
Repeati715 – 743WD 3Add BLAST29
Repeati764 – 794WD 4Add BLAST31
Repeati806 – 836WD 5Add BLAST31
Repeati887 – 917WD 6Add BLAST31

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1786 Eukaryota
ENOG410XNQC LUCA
GeneTreeiENSGT00760000119083
HOGENOMiHOG000231605
HOVERGENiHBG005639
InParanoidiO35242
KOiK18953
OMAiFIWDGNS
OrthoDBiEOG091G01X8
TreeFamiTF324912

Family and domain databases

CDDicd06071 Beach, 1 hit
cd01201 PH_BEACH, 1 hit
Gene3Di1.10.1540.10, 1 hit
2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR004182 GRAM
IPR023362 PH-BEACH_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02138 Beach, 1 hit
PF02893 GRAM, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01026 Beach, 1 hit
SM00568 GRAM, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81837 SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197 BEACH, 1 hit
PS51783 PH_BEACH, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35242-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFTRKRQRE QQLQLYSKER FSLLLLNLEE YYFEQHTAFH VQHQGSQEER
60 70 80 90 100
KIRGSLKICS KSVIFEPDAI SQPILKIPLR DCLKIGKHGE NGANKHFAKA
110 120 130 140 150
KSWGISLIFS QIYFIKEHNI VAPYKIERGK MEYVFELEVS GKVEDVVETL
160 170 180 190 200
LQLHRASCLD KLGDQMAMIT AILQSRLART SFDKNRFQSV SEKLHMECKA
210 220 230 240 250
EMVTPLVTNP GHVCITDTSL YFQPLNGYPK PVVQITLQDV RRIYKRRHGL
260 270 280 290 300
MPLGLEVFCT DDDLCSDIYL KFYEPQDRDD LYFYIATYLE HHAAEHTAES
310 320 330 340 350
YMLQWQRGHL SNYQYLLHLN NLADRSCNDL SQYPVFPWII SDYSSPELDL
360 370 380 390 400
SNPATFRDLS KPVGALNAER LERLLTRYQE MPEPRFMYGS HYSSPGYVLF
410 420 430 440 450
YLVRIAPEYM LCLQNGRFDN ADRMFNSIAE TWKNCLDGAT DFKELIPEFY
460 470 480 490 500
DEDVSFLVNS LKLDLGKRQG GQMVDDVDLP AWASSPQDFL QKNKDALESG
510 520 530 540 550
YVSEHLHEWI DLIFGYKQKG SEAIGAHNVF HPLTYEGGVD LNSIEDPDEK
560 570 580 590 600
VAMLTQILEF GQTPKQLFVT PHPRRITPKF KSLSQASSYN ASLTDSPVSP
610 620 630 640 650
GEESFEDLTE ESRTLAWSNI AKLQLHEQYK IHKEAVTGIA VSCNGSSVFT
660 670 680 690 700
TSQDSTLKMF SKESKMLQRS ISFSNMALSS CLLLPGDTTV ISSSWDNNVY
710 720 730 740 750
FYSIAFGRRQ DTLMGHDDAV SKICWHNDRL YSGSWDSTVK VWSGVPAEMP
760 770 780 790 800
GTKRHQFDLL AELEHDVSVN TINLNAVSTL LVSGTKEGMV NIWDLTTATL
810 820 830 840 850
LHQTSCHSGT VCDAAFSPDS RHILSTGVDG CLNVIDVQTG MLISSMASEE
860 870 880 890 900
PQRCFVWDGN SVLSGSRSGE LLVWDLLGAK VSERIQGHTG AVTCMWMNEQ
910 920
CSSIITGGED RQIMFWKLQY
Length:920
Mass (Da):104,546
Last modified:June 28, 2011 - v2
Checksum:iBB50AD4AB77CE124
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AKK2A2AKK2_MOUSE
Protein FAN
Nsmaf
132Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti385 – 386RF → KS in AAB65394 (PubMed:10228161).Curated2
Sequence conflicti390S → N in AAB65394 (PubMed:10228161).Curated1
Sequence conflicti849E → D in AAB65394 (PubMed:10228161).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013632 mRNA Translation: AAB65394.1
BX510318, AL772306 Genomic DNA Translation: CAM20130.1
AL772306, BX510318 Genomic DNA Translation: CAM27232.1
CH466538 Genomic DNA Translation: EDL05686.1
BC145961 mRNA Translation: AAI45962.1
BC145963 mRNA Translation: AAI45964.1
CCDSiCCDS17952.1
RefSeqiNP_035075.2, NM_010945.2
UniGeneiMm.3059

Genome annotation databases

EnsembliENSMUST00000029910; ENSMUSP00000029910; ENSMUSG00000028245
GeneIDi18201
KEGGimmu:18201
UCSCiuc008rxp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013632 mRNA Translation: AAB65394.1
BX510318, AL772306 Genomic DNA Translation: CAM20130.1
AL772306, BX510318 Genomic DNA Translation: CAM27232.1
CH466538 Genomic DNA Translation: EDL05686.1
BC145961 mRNA Translation: AAI45962.1
BC145963 mRNA Translation: AAI45964.1
CCDSiCCDS17952.1
RefSeqiNP_035075.2, NM_010945.2
UniGeneiMm.3059

3D structure databases

ProteinModelPortaliO35242
SMRiO35242
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029910

PTM databases

iPTMnetiO35242
PhosphoSitePlusiO35242

Proteomic databases

EPDiO35242
MaxQBiO35242
PaxDbiO35242
PeptideAtlasiO35242
PRIDEiO35242

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029910; ENSMUSP00000029910; ENSMUSG00000028245
GeneIDi18201
KEGGimmu:18201
UCSCiuc008rxp.2 mouse

Organism-specific databases

CTDi8439
MGIiMGI:1341864 Nsmaf

Phylogenomic databases

eggNOGiKOG1786 Eukaryota
ENOG410XNQC LUCA
GeneTreeiENSGT00760000119083
HOGENOMiHOG000231605
HOVERGENiHBG005639
InParanoidiO35242
KOiK18953
OMAiFIWDGNS
OrthoDBiEOG091G01X8
TreeFamiTF324912

Enzyme and pathway databases

ReactomeiR-MMU-5626978 TNFR1-mediated ceramide production

Miscellaneous databases

ChiTaRSiNsmaf mouse
PROiPR:O35242
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028245 Expressed in 288 organ(s), highest expression level in female gonad
ExpressionAtlasiO35242 baseline and differential
GenevisibleiO35242 MM

Family and domain databases

CDDicd06071 Beach, 1 hit
cd01201 PH_BEACH, 1 hit
Gene3Di1.10.1540.10, 1 hit
2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR004182 GRAM
IPR023362 PH-BEACH_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02138 Beach, 1 hit
PF02893 GRAM, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01026 Beach, 1 hit
SM00568 GRAM, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81837 SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197 BEACH, 1 hit
PS51783 PH_BEACH, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAN_MOUSE
AccessioniPrimary (citable) accession number: O35242
Secondary accession number(s): A2AKK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 28, 2011
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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