Ptpn9

Functionⁱ

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.By similarity

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	515	Phosphocysteine intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

protein tyrosine phosphatase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of neuron projection development
Source: MGI
Inferred from sequence orthologyⁱ
- 27655914
peptidyl-tyrosine dephosphorylation
Source: MGI
Inferred from sequence orthologyⁱ
- 27655914
positive regulation of protein localization to plasma membrane
Source: MGI
Inferred from sequence orthologyⁱ
- 27655914

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48) Alternative name(s): Protein-tyrosine phosphatase MEG2 Short name: PTPase MEG2
Gene namesⁱ	Name:Ptpn9
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1928376 Ptpn9

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000094765	1 – 593	Tyrosine-protein phosphatase non-receptor type 9Add BLAST		593

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O35239
PaxDbⁱ	O35239
PeptideAtlas More...PeptideAtlasⁱ	O35239
PRIDEⁱ	O35239

PTM databases

iPTMnetⁱ	O35239
PhosphoSitePlusⁱ	O35239

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000032290 Expressed in 278 organ(s), highest expression level in cerebral cortex
CleanExⁱ	MM_PTPN9
ExpressionAtlasⁱ	O35239 baseline and differential
Genevisibleⁱ	O35239 MM

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Nsf	P46460	2	EBI-7297868,EBI-398006

With

Entry

#Exp.

IntAct

Notes

Nsf

P46460

2

EBI-7297868,EBI-398006

Protein-protein interaction databases

BioGridⁱ	207882, 1 interactor
IntActⁱ	O35239, 2 interactors
Molecular INTeraction database More...MINTⁱ	O35239
STRINGⁱ	10090.ENSMUSP00000034832

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O35239
SMRⁱ	O35239
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	84 – 243	CRAL-TRIOPROSITE-ProRule annotationAdd BLAST		160
Domainⁱ	303 – 574	Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST		272

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IF2N Eukaryota COG5599 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150847
HOGENOMⁱ	HOG000006971
HOVERGENⁱ	HBG006880
InParanoidⁱ	O35239
KEGG Orthology (KO) More...KOⁱ	K18038
OMAⁱ	NKCRAGR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JWX
PhylomeDBⁱ	O35239
TreeFamⁱ	TF351975

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00170 SEC14, 1 hit
Gene3Dⁱ	3.40.525.10, 1 hit 3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR001251 CRAL-TRIO_dom IPR036865 CRAL-TRIO_dom_sf IPR036273 CRAL/TRIO_N_dom_sf IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00650 CRAL_TRIO, 1 hit PF00102 Y_phosphatase, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit SM00516 SEC14, 1 hit
SUPFAMⁱ	SSF46938 SSF46938, 1 hit SSF52087 SSF52087, 1 hit SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS50191 CRAL_TRIO, 1 hit PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O35239-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF 
        60         70         80         90        100
LMARKFDVLR AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN 
       110        120        130        140        150
VRDPTGASIA LFTARLHHPH KSAQHVVLQA LFYLLDRAVD SFETQRNGLV 
       160        170        180        190        200
FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS 
       210        220        230        240        250
IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF 
       260        270        280        290        300
LPQVNGHPDP FDEIILSSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK 
       310        320        330        340        350
RGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS 
       360        370        380        390        400
GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM 
       410        420        430        440        450
TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH 
       460        470        480        490        500
NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSMAVGNLGA 
       510        520        530        540        550
RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM 
       560        570        580        590 
RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ

Length:593

Mass (Da):67,970

Last modified:January 24, 2006 - v2

Checksum:ⁱ053451BCD9DC7C61

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1L1STP0	A0A1L1STP0_MOUSE		Tyrosine-protein phosphatase non-re... Tyrosine-protein phosphatase non-receptor type 9	Ptpn9	144	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	190	G → R in AAB66898 (Ref. 1) Curated	1
Sequence conflictⁱ	215	Q → P in AAB66898 (Ref. 1) Curated	1
Sequence conflictⁱ	218	K → T in AAB66898 (Ref. 1) Curated	1
Sequence conflictⁱ	233	E → K in AAB66898 (Ref. 1) Curated	1
Sequence conflictⁱ	277 – 278	SV → TL in AAB66898 (Ref. 1) Curated	2
Sequence conflictⁱ	282 – 285	GPHA → SPLS in AAB66898 (Ref. 1) Curated	4
Sequence conflictⁱ	311 – 312	RR → CL in AAB66898 (Ref. 1) Curated	2
Sequence conflictⁱ	321 – 322	CS → RT in AAB66898 (Ref. 1) Curated	2
Sequence conflictⁱ	326	G → R in AAB66898 (Ref. 1) Curated	1
Sequence conflictⁱ	373	I → N in AAB66898 (Ref. 1) Curated	1
Sequence conflictⁱ	498	L → M in AAB66898 (Ref. 1) Curated	1
Sequence conflictⁱ	545	Q → H in AAB66898 (Ref. 1) Curated	1
Sequence conflictⁱ	576 – 579	EREG → QKER in AAB66898 (Ref. 1) Curated	4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF013490 mRNA Translation: AAB66898.1 BC053017 mRNA Translation: AAH53017.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23215.1
NCBI Reference Sequences More...RefSeqⁱ	NP_062625.2, NM_019651.2
UniGeneⁱ	Mm.325643

Genome annotation databases

Ensemblⁱ	ENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290
GeneIDⁱ	56294
KEGGⁱ	mmu:56294
UCSC genome browser More...UCSCⁱ	uc009ptt.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O35239	Protein tyrosine phosphatase, non-receptor type 9		MOUSE		593	UniRef100_O35239

Protein	Similar proteins		Species	Score	Length	Source
O35239	Tyrosine-protein phosphatase non-receptor type 9	)	HUMAN		593	UniRef90_P43378
Tyrosine-protein phosphatase non-receptor type 9		RAT		593
PTPN9 isoform 1		PANTR		593
PTPN9 isoform 1		PONAB		593
Protein tyrosine phosphatase, non-receptor type 9		GORGO		593
+139

Protein	Similar proteins		Species	Score	Length	Source
O35239	Tyrosine-protein phosphatase non-receptor type 9	)	HUMAN		593	UniRef50_P43378
Tyrosine-protein phosphatase non-receptor type 9		RAT		593
PTPN9 isoform 1		PANTR		593
PTPN9 isoform 1		PONAB		593
Protein tyrosine phosphatase, non-receptor type 9		GORGO		593
+343

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF013490 mRNA Translation: AAB66898.1 BC053017 mRNA Translation: AAH53017.1
CCDSⁱ	CCDS23215.1
RefSeqⁱ	NP_062625.2, NM_019651.2
UniGeneⁱ	Mm.325643

3D structure databases

ProteinModelPortalⁱ	O35239
SMRⁱ	O35239
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207882, 1 interactor
IntActⁱ	O35239, 2 interactors
MINTⁱ	O35239
STRINGⁱ	10090.ENSMUSP00000034832

PTM databases

iPTMnetⁱ	O35239
PhosphoSitePlusⁱ	O35239

Proteomic databases

EPDⁱ	O35239
PaxDbⁱ	O35239
PeptideAtlasⁱ	O35239
PRIDEⁱ	O35239

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56294
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290
GeneIDⁱ	56294
KEGGⁱ	mmu:56294
UCSCⁱ	uc009ptt.1 mouse

Organism-specific databases

CTDⁱ	5780
MGIⁱ	MGI:1928376 Ptpn9

Phylogenomic databases

eggNOGⁱ	ENOG410IF2N Eukaryota COG5599 LUCA
GeneTreeⁱ	ENSGT00930000150847
HOGENOMⁱ	HOG000006971
HOVERGENⁱ	HBG006880
InParanoidⁱ	O35239
KOⁱ	K18038
OMAⁱ	NKCRAGR
OrthoDBⁱ	EOG091G0JWX
PhylomeDBⁱ	O35239
TreeFamⁱ	TF351975

Miscellaneous databases

ChiTaRSⁱ	Ptpn9 mouse
Protein Ontology More...PROⁱ	PR:O35239
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032290 Expressed in 278 organ(s), highest expression level in cerebral cortex
CleanExⁱ	MM_PTPN9
ExpressionAtlasⁱ	O35239 baseline and differential
Genevisibleⁱ	O35239 MM

Family and domain databases

CDDⁱ	cd00170 SEC14, 1 hit
Gene3Dⁱ	3.40.525.10, 1 hit 3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR001251 CRAL-TRIO_dom IPR036865 CRAL-TRIO_dom_sf IPR036273 CRAL/TRIO_N_dom_sf IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfamⁱ	View protein in Pfam PF00650 CRAL_TRIO, 1 hit PF00102 Y_phosphatase, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit SM00516 SEC14, 1 hit
SUPFAMⁱ	SSF46938 SSF46938, 1 hit SSF52087 SSF52087, 1 hit SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS50191 CRAL_TRIO, 1 hit PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTN9_MOUSE
Accessionⁱ	O35239Primary (citable) accession number: O35239 Secondary accession number(s): Q7TSK0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	January 24, 2006
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O35239 (PTN9_MOUSE)

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Tyrosine-protein phosphatase non-receptor type 9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ