UniProtKB - O35239 (PTN9_MOUSE)
Protein
Tyrosine-protein phosphatase non-receptor type 9
Gene
Ptpn9
Organism
Mus musculus (Mouse)
Status
Functioni
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.By similarity
Catalytic activityi
- EC:3.1.3.48PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 515 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: UniProtKB
GO - Biological processi
- negative regulation of neuron projection development Source: MGI
- peptidyl-tyrosine dephosphorylation Source: MGI
- positive regulation of protein localization to plasma membrane Source: MGI
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)Alternative name(s): Protein-tyrosine phosphatase MEG2 Short name: PTPase MEG2 |
Gene namesi | Name:Ptpn9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1928376 Ptpn9 |
Subcellular locationi
Other locations
- Cytoplasm Curated
Other locations
- cytoplasm Source: MGI
- neuron projection terminus Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094765 | 1 – 593 | Tyrosine-protein phosphatase non-receptor type 9Add BLAST | 593 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O35239 |
PaxDbi | O35239 |
PeptideAtlasi | O35239 |
PRIDEi | O35239 |
PTM databases
iPTMneti | O35239 |
PhosphoSitePlusi | O35239 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032290 Expressed in 278 organ(s), highest expression level in cerebral cortex |
ExpressionAtlasi | O35239 baseline and differential |
Genevisiblei | O35239 MM |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Nsf | P46460 | 2 | EBI-7297868,EBI-398006 |
Protein-protein interaction databases
BioGridi | 207882, 1 interactor |
IntActi | O35239, 2 interactors |
MINTi | O35239 |
STRINGi | 10090.ENSMUSP00000034832 |
Structurei
3D structure databases
ProteinModelPortali | O35239 |
SMRi | O35239 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 84 – 243 | CRAL-TRIOPROSITE-ProRule annotationAdd BLAST | 160 | |
Domaini | 303 – 574 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 272 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG410IF2N Eukaryota COG5599 LUCA |
GeneTreei | ENSGT00940000157447 |
HOGENOMi | HOG000006971 |
HOVERGENi | HBG006880 |
InParanoidi | O35239 |
KOi | K18038 |
OMAi | NKCRAGR |
OrthoDBi | 411281at2759 |
PhylomeDBi | O35239 |
TreeFami | TF351975 |
Family and domain databases
CDDi | cd00170 SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR001251 CRAL-TRIO_dom IPR036865 CRAL-TRIO_dom_sf IPR036273 CRAL/TRIO_N_dom_sf IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00650 CRAL_TRIO, 1 hit PF00102 Y_phosphatase, 1 hit |
PRINTSi | PR00700 PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit SM00516 SEC14, 1 hit |
SUPFAMi | SSF46938 SSF46938, 1 hit SSF52087 SSF52087, 1 hit SSF52799 SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50191 CRAL_TRIO, 1 hit PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O35239-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF
60 70 80 90 100
LMARKFDVLR AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN
110 120 130 140 150
VRDPTGASIA LFTARLHHPH KSAQHVVLQA LFYLLDRAVD SFETQRNGLV
160 170 180 190 200
FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS
210 220 230 240 250
IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF
260 270 280 290 300
LPQVNGHPDP FDEIILSSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK
310 320 330 340 350
RGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS
360 370 380 390 400
GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM
410 420 430 440 450
TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH
460 470 480 490 500
NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSMAVGNLGA
510 520 530 540 550
RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM
560 570 580 590
RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1STP0 | A0A1L1STP0_MOUSE | Tyrosine-protein phosphatase non-re... | Ptpn9 | 144 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 190 | G → R in AAB66898 (Ref. 1) Curated | 1 | |
Sequence conflicti | 215 | Q → P in AAB66898 (Ref. 1) Curated | 1 | |
Sequence conflicti | 218 | K → T in AAB66898 (Ref. 1) Curated | 1 | |
Sequence conflicti | 233 | E → K in AAB66898 (Ref. 1) Curated | 1 | |
Sequence conflicti | 277 – 278 | SV → TL in AAB66898 (Ref. 1) Curated | 2 | |
Sequence conflicti | 282 – 285 | GPHA → SPLS in AAB66898 (Ref. 1) Curated | 4 | |
Sequence conflicti | 311 – 312 | RR → CL in AAB66898 (Ref. 1) Curated | 2 | |
Sequence conflicti | 321 – 322 | CS → RT in AAB66898 (Ref. 1) Curated | 2 | |
Sequence conflicti | 326 | G → R in AAB66898 (Ref. 1) Curated | 1 | |
Sequence conflicti | 373 | I → N in AAB66898 (Ref. 1) Curated | 1 | |
Sequence conflicti | 498 | L → M in AAB66898 (Ref. 1) Curated | 1 | |
Sequence conflicti | 545 | Q → H in AAB66898 (Ref. 1) Curated | 1 | |
Sequence conflicti | 576 – 579 | EREG → QKER in AAB66898 (Ref. 1) Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF013490 mRNA Translation: AAB66898.1 BC053017 mRNA Translation: AAH53017.1 |
CCDSi | CCDS23215.1 |
RefSeqi | NP_062625.2, NM_019651.2 |
UniGenei | Mm.325643 |
Genome annotation databases
Ensembli | ENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290 |
GeneIDi | 56294 |
KEGGi | mmu:56294 |
UCSCi | uc009ptt.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF013490 mRNA Translation: AAB66898.1 BC053017 mRNA Translation: AAH53017.1 |
CCDSi | CCDS23215.1 |
RefSeqi | NP_062625.2, NM_019651.2 |
UniGenei | Mm.325643 |
3D structure databases
ProteinModelPortali | O35239 |
SMRi | O35239 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 207882, 1 interactor |
IntActi | O35239, 2 interactors |
MINTi | O35239 |
STRINGi | 10090.ENSMUSP00000034832 |
PTM databases
iPTMneti | O35239 |
PhosphoSitePlusi | O35239 |
Proteomic databases
EPDi | O35239 |
PaxDbi | O35239 |
PeptideAtlasi | O35239 |
PRIDEi | O35239 |
Protocols and materials databases
DNASUi | 56294 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290 |
GeneIDi | 56294 |
KEGGi | mmu:56294 |
UCSCi | uc009ptt.1 mouse |
Organism-specific databases
CTDi | 5780 |
MGIi | MGI:1928376 Ptpn9 |
Phylogenomic databases
eggNOGi | ENOG410IF2N Eukaryota COG5599 LUCA |
GeneTreei | ENSGT00940000157447 |
HOGENOMi | HOG000006971 |
HOVERGENi | HBG006880 |
InParanoidi | O35239 |
KOi | K18038 |
OMAi | NKCRAGR |
OrthoDBi | 411281at2759 |
PhylomeDBi | O35239 |
TreeFami | TF351975 |
Miscellaneous databases
ChiTaRSi | Ptpn9 mouse |
PROi | PR:O35239 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032290 Expressed in 278 organ(s), highest expression level in cerebral cortex |
ExpressionAtlasi | O35239 baseline and differential |
Genevisiblei | O35239 MM |
Family and domain databases
CDDi | cd00170 SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR001251 CRAL-TRIO_dom IPR036865 CRAL-TRIO_dom_sf IPR036273 CRAL/TRIO_N_dom_sf IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00650 CRAL_TRIO, 1 hit PF00102 Y_phosphatase, 1 hit |
PRINTSi | PR00700 PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit SM00516 SEC14, 1 hit |
SUPFAMi | SSF46938 SSF46938, 1 hit SSF52087 SSF52087, 1 hit SSF52799 SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50191 CRAL_TRIO, 1 hit PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | PTN9_MOUSE | |
Accessioni | O35239Primary (citable) accession number: O35239 Secondary accession number(s): Q7TSK0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | January 24, 2006 | |
Last modified: | February 13, 2019 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot