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Protein

Tyrosine-protein phosphatase non-receptor type 9

Gene

Ptpn9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei515Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase MEG2
Short name:
PTPase MEG2
Gene namesi
Name:Ptpn9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1928376 Ptpn9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947651 – 593Tyrosine-protein phosphatase non-receptor type 9Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO35239
PaxDbiO35239
PeptideAtlasiO35239
PRIDEiO35239

PTM databases

iPTMnetiO35239
PhosphoSitePlusiO35239

Expressioni

Gene expression databases

BgeeiENSMUSG00000032290 Expressed in 278 organ(s), highest expression level in cerebral cortex
CleanExiMM_PTPN9
ExpressionAtlasiO35239 baseline and differential
GenevisibleiO35239 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NsfP464602EBI-7297868,EBI-398006

Protein-protein interaction databases

BioGridi207882, 1 interactor
IntActiO35239, 2 interactors
MINTiO35239
STRINGi10090.ENSMUSP00000034832

Structurei

3D structure databases

ProteinModelPortaliO35239
SMRiO35239
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 243CRAL-TRIOPROSITE-ProRule annotationAdd BLAST160
Domaini303 – 574Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST272

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IF2N Eukaryota
COG5599 LUCA
GeneTreeiENSGT00930000150847
HOGENOMiHOG000006971
HOVERGENiHBG006880
InParanoidiO35239
KOiK18038
OMAiNKCRAGR
OrthoDBiEOG091G0JWX
PhylomeDBiO35239
TreeFamiTF351975

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR036273 CRAL/TRIO_N_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35239-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF
60 70 80 90 100
LMARKFDVLR AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN
110 120 130 140 150
VRDPTGASIA LFTARLHHPH KSAQHVVLQA LFYLLDRAVD SFETQRNGLV
160 170 180 190 200
FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS
210 220 230 240 250
IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF
260 270 280 290 300
LPQVNGHPDP FDEIILSSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK
310 320 330 340 350
RGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS
360 370 380 390 400
GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM
410 420 430 440 450
TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH
460 470 480 490 500
NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSMAVGNLGA
510 520 530 540 550
RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM
560 570 580 590
RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ
Length:593
Mass (Da):67,970
Last modified:January 24, 2006 - v2
Checksum:i053451BCD9DC7C61
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1STP0A0A1L1STP0_MOUSE
Tyrosine-protein phosphatase non-re...
Ptpn9
144Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190G → R in AAB66898 (Ref. 1) Curated1
Sequence conflicti215Q → P in AAB66898 (Ref. 1) Curated1
Sequence conflicti218K → T in AAB66898 (Ref. 1) Curated1
Sequence conflicti233E → K in AAB66898 (Ref. 1) Curated1
Sequence conflicti277 – 278SV → TL in AAB66898 (Ref. 1) Curated2
Sequence conflicti282 – 285GPHA → SPLS in AAB66898 (Ref. 1) Curated4
Sequence conflicti311 – 312RR → CL in AAB66898 (Ref. 1) Curated2
Sequence conflicti321 – 322CS → RT in AAB66898 (Ref. 1) Curated2
Sequence conflicti326G → R in AAB66898 (Ref. 1) Curated1
Sequence conflicti373I → N in AAB66898 (Ref. 1) Curated1
Sequence conflicti498L → M in AAB66898 (Ref. 1) Curated1
Sequence conflicti545Q → H in AAB66898 (Ref. 1) Curated1
Sequence conflicti576 – 579EREG → QKER in AAB66898 (Ref. 1) Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013490 mRNA Translation: AAB66898.1
BC053017 mRNA Translation: AAH53017.1
CCDSiCCDS23215.1
RefSeqiNP_062625.2, NM_019651.2
UniGeneiMm.325643

Genome annotation databases

EnsembliENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290
GeneIDi56294
KEGGimmu:56294
UCSCiuc009ptt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013490 mRNA Translation: AAB66898.1
BC053017 mRNA Translation: AAH53017.1
CCDSiCCDS23215.1
RefSeqiNP_062625.2, NM_019651.2
UniGeneiMm.325643

3D structure databases

ProteinModelPortaliO35239
SMRiO35239
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207882, 1 interactor
IntActiO35239, 2 interactors
MINTiO35239
STRINGi10090.ENSMUSP00000034832

PTM databases

iPTMnetiO35239
PhosphoSitePlusiO35239

Proteomic databases

EPDiO35239
PaxDbiO35239
PeptideAtlasiO35239
PRIDEiO35239

Protocols and materials databases

DNASUi56294
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290
GeneIDi56294
KEGGimmu:56294
UCSCiuc009ptt.1 mouse

Organism-specific databases

CTDi5780
MGIiMGI:1928376 Ptpn9

Phylogenomic databases

eggNOGiENOG410IF2N Eukaryota
COG5599 LUCA
GeneTreeiENSGT00930000150847
HOGENOMiHOG000006971
HOVERGENiHBG006880
InParanoidiO35239
KOiK18038
OMAiNKCRAGR
OrthoDBiEOG091G0JWX
PhylomeDBiO35239
TreeFamiTF351975

Miscellaneous databases

ChiTaRSiPtpn9 mouse
PROiPR:O35239
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032290 Expressed in 278 organ(s), highest expression level in cerebral cortex
CleanExiMM_PTPN9
ExpressionAtlasiO35239 baseline and differential
GenevisibleiO35239 MM

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR036273 CRAL/TRIO_N_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTN9_MOUSE
AccessioniPrimary (citable) accession number: O35239
Secondary accession number(s): Q7TSK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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