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Protein

Kinesin-like protein KIFC3

Gene

Kifc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi526 – 533ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, minus-end-directed Source: MGI
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: GO_Central

GO - Biological processi

  • epithelial cell-cell adhesion Source: UniProtKB
  • Golgi organization Source: MGI
  • microtubule-based movement Source: GO_Central
  • microtubule-based process Source: MGI
  • zonula adherens maintenance Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIFC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kifc3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109202 Kifc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254321 – 824Kinesin-like protein KIFC3Add BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei811PhosphoserineBy similarity1
Modified residuei815PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
O35231

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O35231

PRoteomics IDEntifications database

More...
PRIDEi
O35231

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O35231

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O35231

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominant expression in the kidney, testis and ovary. Also expressed in brain, heart, liver, lung and uterus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000031788 Expressed in 261 organ(s), highest expression level in lens of camera-type eye

CleanEx database of gene expression profiles

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CleanExi
MM_KIFC3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O35231 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O35231 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with annexin XIIIB.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
200954, 3 interactors

Protein interaction database and analysis system

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IntActi
O35231, 2 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000034240

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O35231

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O35231

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini443 – 766Kinesin motorPROSITE-ProRule annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili100 – 360Sequence analysisAdd BLAST261
Coiled coili393 – 430Sequence analysisAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0239 Eukaryota
COG5059 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154022

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052259

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O35231

KEGG Orthology (KO)

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KOi
K10406

Database of Orthologous Groups

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OrthoDBi
364605at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O35231

TreeFam database of animal gene trees

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TreeFami
TF105238

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027325 KIFC3
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR24115 PTHR24115, 1 hit
PTHR24115:SF387 PTHR24115:SF387, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00225 Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O35231-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPSRRTWNL GATPSLRGLW RVGRVQEPKP GMARPAPASP AARPFPHTGQ
60 70 80 90 100
GRLRTGRGKD ILPSGEEDST SRTAARPSLA QCRALSVDWP GPRSPHRLYL
110 120 130 140 150
TVQVENLKEK LISQAQEVSR LRSELGGTDA EKHRDRLMVE NEQLRQELRR
160 170 180 190 200
CEVELQELRA QPVVPCEGCE HSQESSQLRD KLSQLQLEVA ENKGMLSELN
210 220 230 240 250
LEVQQKTDRL AEVELRLKDC LAEKAQEEER LSRRLRDSHE TIASLRAQSP
260 270 280 290 300
PVKYVIKTVE VESSKTKQAL SESQTRNQHL QEQVAMQRQV LKEMEQQLQN
310 320 330 340 350
SHQLTVQLRA QIAMYEAELE RAHGQMLEEM QSLEEDKNRA IEEAFARAQV
360 370 380 390 400
EMKAVHENLA GVRTNLLTLQ PALRTLTNDY NGLKRQVRGF PLLLQEALRS
410 420 430 440 450
VKAEIGQAIE EVNSNNQELL RKYRRELQLR KKCHNELVRL KGNIRVIARV
460 470 480 490 500
RPVTKEDGEG PEATNAVTFD PDDDSIIHLL HKGKPVSFEL DKVFSPWASQ
510 520 530 540 550
QDVFQEVQAL ITSCIDGFNV CIFAYGQTGA GKTYTMEGTP ENPGINQRAL
560 570 580 590 600
QLLFSEVQEK ASDWQYNITV SAAEIYNEVL RDLLGKEPQE KLEIRLCPDG
610 620 630 640 650
SGQLYVPGLT EFQVQSVDDI NKVFEFGYNN RTTEFTNLNE HSSRSHALLI
660 670 680 690 700
VTVRGVDCST GLRTTGKLNL VDLAGSERVG KSGAEGNRLR EAQHINRSLS
710 720 730 740 750
ALGDVIAALR SRQGHVPFRN SKLTYLLQDS LSGDSKTLMV VQVSPVEKNT
760 770 780 790 800
SETLYSLRFA ERVRSVELGP GSRRTELGSW SSQEHLEWEP ACQTPQPTAR
810 820
AHSAPGSGTS SRPGSIRRKL QPSA
Length:824
Mass (Da):92,556
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE7EF66140725547
GO
Isoform 2 (identifier: O35231-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     116-125: QEVSRLRSEL → MPPLGPGSPQ

Show »
Length:709
Mass (Da):79,740
Checksum:iCF5CF42160DEADE4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWU7E9PWU7_MOUSE
Kinesin-like protein
Kifc3
778Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J220A0A0R4J220_MOUSE
Kinesin-like protein
Kifc3 mCG_12287
709Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLM0A0A1D5RLM0_MOUSE
Kinesin-like protein
Kifc3
687Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMF3A0A1D5RMF3_MOUSE
Kinesin-like protein KIFC3
Kifc3
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLS5A0A1D5RLS5_MOUSE
Kinesin-like protein KIFC3
Kifc3
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMG8A0A1D5RMG8_MOUSE
Kinesin-like protein KIFC3
Kifc3
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMI2A0A1D5RMI2_MOUSE
Kinesin-like protein KIFC3
Kifc3
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH70429 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE21409 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67 – 74EDSTSRTA → HCQPTFPT in BAE21409 (PubMed:16141072).Curated8
Sequence conflicti76 – 83RPSLAQCR → GLRAQHQP in BAE21409 (PubMed:16141072).Curated8
Sequence conflicti86 – 103SVDWP…YLTVQ → ETAKVRTSALGVVRRCGE in BAE21409 (PubMed:16141072).CuratedAdd BLAST18
Sequence conflicti122R → Q in BAE92567 (PubMed:11581287).Curated1
Sequence conflicti214 – 215EL → DV in AAC39967 (PubMed:11154264).Curated2
Sequence conflicti237D → Y in BAE92567 (PubMed:11581287).Curated1
Sequence conflicti573A → R in AAC39967 (PubMed:11154264).Curated1
Sequence conflicti659S → R in AAC39967 (PubMed:11154264).Curated1
Sequence conflicti690R → Q in BAE92567 (PubMed:11581287).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0223631 – 115Missing in isoform 2. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_022364116 – 125QEVSRLRSEL → MPPLGPGSPQ in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D49546 mRNA Translation: BAE92567.1
AF013118 mRNA Translation: AAC39967.2
BC004069 mRNA Translation: AAH04069.1
BC016118 mRNA Translation: AAH16118.1
BC023374 mRNA Translation: AAH23374.1
BC070429 mRNA Translation: AAH70429.1 Different initiation.
AK132895 mRNA Translation: BAE21409.1 Different initiation.
AK135926 mRNA Translation: BAE22727.1
AB001457 mRNA Translation: BAA22399.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS52640.1 [O35231-1]

NCBI Reference Sequences

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RefSeqi
NP_001139303.1, NM_001145831.1
NP_001139304.1, NM_001145832.1
NP_034761.3, NM_010631.2 [O35231-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.378951

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000034240; ENSMUSP00000034240; ENSMUSG00000031788 [O35231-1]
ENSMUST00000169353; ENSMUSP00000127427; ENSMUSG00000031788 [O35231-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
16582

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:16582

UCSC genome browser

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UCSCi
uc009mxu.1 mouse [O35231-2]
uc009mxv.1 mouse [O35231-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49546 mRNA Translation: BAE92567.1
AF013118 mRNA Translation: AAC39967.2
BC004069 mRNA Translation: AAH04069.1
BC016118 mRNA Translation: AAH16118.1
BC023374 mRNA Translation: AAH23374.1
BC070429 mRNA Translation: AAH70429.1 Different initiation.
AK132895 mRNA Translation: BAE21409.1 Different initiation.
AK135926 mRNA Translation: BAE22727.1
AB001457 mRNA Translation: BAA22399.1
CCDSiCCDS52640.1 [O35231-1]
RefSeqiNP_001139303.1, NM_001145831.1
NP_001139304.1, NM_001145832.1
NP_034761.3, NM_010631.2 [O35231-1]
UniGeneiMm.378951

3D structure databases

ProteinModelPortaliO35231
SMRiO35231
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200954, 3 interactors
IntActiO35231, 2 interactors
STRINGi10090.ENSMUSP00000034240

PTM databases

iPTMnetiO35231
PhosphoSitePlusiO35231

Proteomic databases

MaxQBiO35231
PaxDbiO35231
PRIDEiO35231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034240; ENSMUSP00000034240; ENSMUSG00000031788 [O35231-1]
ENSMUST00000169353; ENSMUSP00000127427; ENSMUSG00000031788 [O35231-2]
GeneIDi16582
KEGGimmu:16582
UCSCiuc009mxu.1 mouse [O35231-2]
uc009mxv.1 mouse [O35231-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3801
MGIiMGI:109202 Kifc3

Phylogenomic databases

eggNOGiKOG0239 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000154022
HOVERGENiHBG052259
InParanoidiO35231
KOiK10406
OrthoDBi364605at2759
PhylomeDBiO35231
TreeFamiTF105238

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Kifc3 mouse

Protein Ontology

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PROi
PR:O35231

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031788 Expressed in 261 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_KIFC3
ExpressionAtlasiO35231 baseline and differential
GenevisibleiO35231 MM

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027325 KIFC3
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF387 PTHR24115:SF387, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIFC3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35231
Secondary accession number(s): O35072
, Q1WNZ8, Q3UX36, Q3V0U4, Q6NS71, Q8R3Y4, Q91YQ2, Q99KP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 135 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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