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UniProtKB - O35227 (ADAM7_MOUSE)
Protein
Disintegrin and metalloproteinase domain-containing protein 7
Gene
Adam7
Organism
Mus musculus (Mouse)
Status
Functioni
May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein.
GO - Molecular functioni
- endopeptidase activity Source: MGI
- metalloendopeptidase activity Source: InterPro
- metallopeptidase activity Source: GO_Central
Protein family/group databases
MEROPSi | M12.956 |
Names & Taxonomyi
Protein namesi | Recommended name: Disintegrin and metalloproteinase domain-containing protein 7Short name: ADAM 7 |
Gene namesi | Name:Adam7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107247, Adam7 |
VEuPathDBi | HostDB:ENSMUSG00000022056 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- apical part of cell Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 667 | ExtracellularSequence analysisAdd BLAST | 644 | |
Transmembranei | 668 – 689 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 690 – 789 | CytoplasmicSequence analysisAdd BLAST | 100 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000419681 | 24 – 176 | By similarityAdd BLAST | 153 | |
ChainiPRO_0000029056 | 177 – 789 | Disintegrin and metalloproteinase domain-containing protein 7Add BLAST | 613 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 167 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 174 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 310 ↔ 388 | By similarity | ||
Disulfide bondi | 350 ↔ 372 | By similarity | ||
Disulfide bondi | 352 ↔ 357 | By similarity | ||
Disulfide bondi | 459 ↔ 479 | By similarity | ||
Glycosylationi | 583 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 628 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 664 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O35227 |
PRIDEi | O35227 |
ProteomicsDBi | 281937 |
PTM databases
GlyGeni | O35227, 6 sites |
PhosphoSitePlusi | O35227 |
Expressioni
Tissue specificityi
Expressed in the apical region of the proximal caput epididymal epithelium and in the anterior pituitary, specifically, in the gonadotrophes.
Gene expression databases
Bgeei | ENSMUSG00000022056, Expressed in epididymal fat pad and 57 other tissues |
Genevisiblei | O35227, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 197971, 9 interactors |
STRINGi | 10090.ENSMUSP00000022640 |
Miscellaneous databases
RNActi | O35227, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 199 – 393 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 195 | |
Domaini | 401 – 487 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 764 – 789 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 769 – 783 | Polar residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000161406 |
HOGENOMi | CLU_012714_6_0_1 |
InParanoidi | O35227 |
OMAi | CDFPEVC |
OrthoDBi | 162519at2759 |
PhylomeDBi | O35227 |
TreeFami | TF314733 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O35227-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTTGIFWMT VLISHIQERG IVGVEGQELV HPKKLPLLHK RDLERIHDSD
60 70 80 90 100
IPEEYEEELL YEIKLGKKTL ILHLLKAREF LSSNYSETYY NVKREVFTKH
110 120 130 140 150
PQILDHCFYQ GSIIHEFDSA ASISTCNGLR GFFRVNDQRY LIEPVKYSDD
160 170 180 190 200
GEHLVYKYNV KAPYATNHSC VGLNFTKKSA LIDVENIEEH NAEDHHKEKF
210 220 230 240 250
IELFVVADEY VYRRNNKPQN KLRKRIWGMV NFVNMIYKTL NIHVTLAGFE
260 270 280 290 300
IWSAGDKIEI VSNLESTLLH FSTWQETVLK KRKDFDHVIL LSGKWLYTSM
310 320 330 340 350
QGIAYPGGIC QILRSCSVVK DLLPDVNIIG NRMAHQLGHS LGMQHDGFPC
360 370 380 390 400
TCPLGKCVMG DGSIPAIKFS KCSQTQYQQF LQDQKPACIL NNPFPEEFND
410 420 430 440 450
YPFCGNKKVD EGEECDCGPV QECTNPCCDA HKCVLKPGFT CVEGECCESC
460 470 480 490 500
QMKKEGAVCR LAKNECDISE VCTGYSPECP KDEFQANGFP CRNGEGYCFM
510 520 530 540 550
GLCPTRNEQC SELFIGGAEE SHSLCYRMNK KGNRFGYCKN KGNTFVPCEE
560 570 580 590 600
KDLKCGKIYC SGGRPSSRLG EDKAYNLKNV KQNVTIKCRT MFLHHNSRDM
610 620 630 640 650
GLVNSGTKCG DGMVCSNGEC IEMEKAYNST ICSSPCDEND VDDNEPECQC
660 670 680 690 700
EEGSIITEWG EALNLTSVSI MVIVLVMVII GVGLVILLIR YQKCIKMKQV
710 720 730 740 750
QSSPREIRGV ENKGYFPEEH QTRSEPILTD IHPLHTTAES LERVPSSFSS
760 770 780
PHYITLKSVS KDSRGIADPK QTDNVNLNLD TQSGCERLG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 – 3 | LT → FP in AAC53368 (PubMed:9322939).Curated | 2 | |
Sequence conflicti | 8 | W → L in AAC53368 (PubMed:9322939).Curated | 1 | |
Sequence conflicti | 28 | E → Q in AAC53368 (PubMed:9322939).Curated | 1 | |
Sequence conflicti | 155 | V → M in AAC53368 (PubMed:9322939).Curated | 1 | |
Sequence conflicti | 224 – 225 | KR → NG in AAC53368 (PubMed:9322939).Curated | 2 | |
Sequence conflicti | 253 | S → L in AAC53368 (PubMed:9322939).Curated | 1 | |
Sequence conflicti | 397 | E → K in AAC53368 (PubMed:9322939).Curated | 1 | |
Sequence conflicti | 414 | E → K in AAC53368 (PubMed:9322939).Curated | 1 | |
Sequence conflicti | 495 | E → K in AAC53368 (PubMed:9322939).Curated | 1 | |
Sequence conflicti | 572 – 574 | DKA → NKT in AAC53368 (PubMed:9322939).Curated | 3 | |
Sequence conflicti | 679 | Missing in AAC53368 (PubMed:9322939).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF013107 mRNA Translation: AAC53368.1 AC154706 Genomic DNA No translation available. |
CCDSi | CCDS27234.1 |
RefSeqi | NP_031428.2, NM_007402.2 |
Genome annotation databases
Ensembli | ENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056 |
GeneIDi | 11500 |
KEGGi | mmu:11500 |
UCSCi | uc007ulr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF013107 mRNA Translation: AAC53368.1 AC154706 Genomic DNA No translation available. |
CCDSi | CCDS27234.1 |
RefSeqi | NP_031428.2, NM_007402.2 |
3D structure databases
SMRi | O35227 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 197971, 9 interactors |
STRINGi | 10090.ENSMUSP00000022640 |
Protein family/group databases
MEROPSi | M12.956 |
PTM databases
GlyGeni | O35227, 6 sites |
PhosphoSitePlusi | O35227 |
Proteomic databases
PaxDbi | O35227 |
PRIDEi | O35227 |
ProteomicsDBi | 281937 |
Protocols and materials databases
Antibodypediai | 22842, 87 antibodies from 22 providers |
DNASUi | 11500 |
Genome annotation databases
Ensembli | ENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056 |
GeneIDi | 11500 |
KEGGi | mmu:11500 |
UCSCi | uc007ulr.1, mouse |
Organism-specific databases
CTDi | 8756 |
MGIi | MGI:107247, Adam7 |
VEuPathDBi | HostDB:ENSMUSG00000022056 |
Phylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000161406 |
HOGENOMi | CLU_012714_6_0_1 |
InParanoidi | O35227 |
OMAi | CDFPEVC |
OrthoDBi | 162519at2759 |
PhylomeDBi | O35227 |
TreeFami | TF314733 |
Miscellaneous databases
BioGRID-ORCSi | 11500, 1 hit in 63 CRISPR screens |
PROi | PR:O35227 |
RNActi | O35227, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022056, Expressed in epididymal fat pad and 57 other tissues |
Genevisiblei | O35227, MM |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAM7_MOUSE | |
Accessioni | O35227Primary (citable) accession number: O35227 Secondary accession number(s): F8VQC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot