Adam7

Functionⁱ

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein.

GO - Molecular functionⁱ

endopeptidase activity
Source: MGI
Inferred from direct assayⁱ
- 15574878
metalloendopeptidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M12.956

MEROPSⁱ

M12.956

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Disintegrin and metalloproteinase domain-containing protein 7 Short name: ADAM 7
Gene namesⁱ	Name:Adam7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:107247 Adam7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 667	ExtracellularSequence analysisAdd BLAST	644
Transmembraneⁱ	668 – 689	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	690 – 789	CytoplasmicSequence analysisAdd BLAST	100

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST	23
PropeptideⁱPRO_0000419681	24 – 176	By similarityAdd BLAST	153
ChainⁱPRO_0000029056	177 – 789	Disintegrin and metalloproteinase domain-containing protein 7Add BLAST	613

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	84	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	167	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	174	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	310 ↔ 388	By similarity
Disulfide bondⁱ	350 ↔ 372	By similarity
Disulfide bondⁱ	352 ↔ 357	By similarity
Disulfide bondⁱ	459 ↔ 479	By similarity
Glycosylationⁱ	583	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	628	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	664	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O35227
PRIDEⁱ	O35227

PTM databases

PhosphoSitePlusⁱ	O35227

PhosphoSitePlusⁱ

O35227

Expressionⁱ

Tissue specificityⁱ

Expressed in the apical region of the proximal caput epididymal epithelium and in the anterior pituitary, specifically, in the gonadotrophes.

Gene expression databases

Bgeeⁱ	ENSMUSG00000022056 Expressed in 29 organ(s), highest expression level in epididymal fat pad
CleanExⁱ	MM_ADAM7
Genevisibleⁱ	O35227 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000022640

STRINGⁱ

10090.ENSMUSP00000022640

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O35227
SMRⁱ	O35227
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	199 – 393	Peptidase M12BPROSITE-ProRule annotationAdd BLAST		195
Domainⁱ	401 – 487	DisintegrinPROSITE-ProRule annotationAdd BLAST		87

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	488 – 667	Cys-richAdd BLAST		180

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3607 Eukaryota ENOG410XX2M LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144014
HOGENOMⁱ	HOG000230883
HOVERGENⁱ	HBG006978
InParanoidⁱ	O35227
KEGG Orthology (KO) More...KOⁱ	K16071
OMAⁱ	MDHCFYQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01NX
TreeFamⁱ	TF314733

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Dⁱ	3.40.390.10, 1 hit 4.10.70.10, 1 hit
InterProⁱ	View protein in InterPro IPR006586 ADAM_Cys-rich IPR018358 Disintegrin_CS IPR001762 Disintegrin_dom IPR036436 Disintegrin_dom_sf IPR024079 MetalloPept_cat_dom_sf IPR001590 Peptidase_M12B IPR002870 Peptidase_M12B_N IPR034027 Reprolysin_adamalysin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08516 ADAM_CR, 1 hit PF00200 Disintegrin, 1 hit PF01562 Pep_M12B_propep, 1 hit PF01421 Reprolysin, 1 hit
PRINTSⁱ	PR00289 DISINTEGRIN
SMARTⁱ	View protein in SMART SM00608 ACR, 1 hit SM00050 DISIN, 1 hit
SUPFAMⁱ	SSF57552 SSF57552, 1 hit
PROSITEⁱ	View protein in PROSITE PS50215 ADAM_MEPRO, 1 hit PS00427 DISINTEGRIN_1, 1 hit PS50214 DISINTEGRIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O35227-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLTTGIFWMT VLISHIQERG IVGVEGQELV HPKKLPLLHK RDLERIHDSD 
        60         70         80         90        100
IPEEYEEELL YEIKLGKKTL ILHLLKAREF LSSNYSETYY NVKREVFTKH 
       110        120        130        140        150
PQILDHCFYQ GSIIHEFDSA ASISTCNGLR GFFRVNDQRY LIEPVKYSDD 
       160        170        180        190        200
GEHLVYKYNV KAPYATNHSC VGLNFTKKSA LIDVENIEEH NAEDHHKEKF 
       210        220        230        240        250
IELFVVADEY VYRRNNKPQN KLRKRIWGMV NFVNMIYKTL NIHVTLAGFE 
       260        270        280        290        300
IWSAGDKIEI VSNLESTLLH FSTWQETVLK KRKDFDHVIL LSGKWLYTSM 
       310        320        330        340        350
QGIAYPGGIC QILRSCSVVK DLLPDVNIIG NRMAHQLGHS LGMQHDGFPC 
       360        370        380        390        400
TCPLGKCVMG DGSIPAIKFS KCSQTQYQQF LQDQKPACIL NNPFPEEFND 
       410        420        430        440        450
YPFCGNKKVD EGEECDCGPV QECTNPCCDA HKCVLKPGFT CVEGECCESC 
       460        470        480        490        500
QMKKEGAVCR LAKNECDISE VCTGYSPECP KDEFQANGFP CRNGEGYCFM 
       510        520        530        540        550
GLCPTRNEQC SELFIGGAEE SHSLCYRMNK KGNRFGYCKN KGNTFVPCEE 
       560        570        580        590        600
KDLKCGKIYC SGGRPSSRLG EDKAYNLKNV KQNVTIKCRT MFLHHNSRDM 
       610        620        630        640        650
GLVNSGTKCG DGMVCSNGEC IEMEKAYNST ICSSPCDEND VDDNEPECQC 
       660        670        680        690        700
EEGSIITEWG EALNLTSVSI MVIVLVMVII GVGLVILLIR YQKCIKMKQV 
       710        720        730        740        750
QSSPREIRGV ENKGYFPEEH QTRSEPILTD IHPLHTTAES LERVPSSFSS 
       760        770        780 
PHYITLKSVS KDSRGIADPK QTDNVNLNLD TQSGCERLG

Length:789

Mass (Da):89,188

Last modified:October 3, 2012 - v2

Checksum:ⁱ9C14BAE5D589AF76

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2 – 3	LT → FP in AAC53368 (PubMed:9322939).Curated	2
Sequence conflictⁱ	8	W → L in AAC53368 (PubMed:9322939).Curated	1
Sequence conflictⁱ	28	E → Q in AAC53368 (PubMed:9322939).Curated	1
Sequence conflictⁱ	155	V → M in AAC53368 (PubMed:9322939).Curated	1
Sequence conflictⁱ	224 – 225	KR → NG in AAC53368 (PubMed:9322939).Curated	2
Sequence conflictⁱ	253	S → L in AAC53368 (PubMed:9322939).Curated	1
Sequence conflictⁱ	397	E → K in AAC53368 (PubMed:9322939).Curated	1
Sequence conflictⁱ	414	E → K in AAC53368 (PubMed:9322939).Curated	1
Sequence conflictⁱ	495	E → K in AAC53368 (PubMed:9322939).Curated	1
Sequence conflictⁱ	572 – 574	DKA → NKT in AAC53368 (PubMed:9322939).Curated	3
Sequence conflictⁱ	679	Missing in AAC53368 (PubMed:9322939).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF013107 mRNA Translation: AAC53368.1 AC154706 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27234.1
NCBI Reference Sequences More...RefSeqⁱ	NP_031428.2, NM_007402.2
UniGeneⁱ	Mm.261495

Genome annotation databases

Ensemblⁱ	ENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056
GeneIDⁱ	11500
KEGGⁱ	mmu:11500
UCSC genome browser More...UCSCⁱ	uc007ulr.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O35227	Uncharacterized protein		MOUSE		167	UniRef100_O35227
A disintegrin and metallopeptidase domain 7 (Fragment)		western European house mouse		89

Protein	Similar proteins		Species	Score	Length	Source
O35227	Uncharacterized protein		MOUSE		167	UniRef90_O35227
A disintegrin and metallopeptidase domain 7 (Fragment)		western European house mouse		89
UPI000A312FC7		MUSPA		789
UPI000A317DD6		MUSCR		789
UPI000A31A0FD		MUSCR		789

Protein	Similar proteins		Species	Score	Length	Source
O35227	Disintegrin and metalloproteinase domain-containing protein 7		HUMAN		754	UniRef50_Q9H2U9
Disintegrin and metalloproteinase domain-containing protein 7		RAT		789
Uncharacterized protein		PANPA		777
ADAM metallopeptidase domain 7		GORGO		777
ADAM metallopeptidase domain 7		PANTR		777
+79

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF013107 mRNA Translation: AAC53368.1 AC154706 Genomic DNA No translation available.
CCDSⁱ	CCDS27234.1
RefSeqⁱ	NP_031428.2, NM_007402.2
UniGeneⁱ	Mm.261495

3D structure databases

ProteinModelPortalⁱ	O35227
SMRⁱ	O35227
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000022640

STRINGⁱ

10090.ENSMUSP00000022640

Protein family/group databases

MEROPSⁱ	M12.956

MEROPSⁱ

M12.956

PTM databases

PhosphoSitePlusⁱ	O35227

PhosphoSitePlusⁱ

O35227

Proteomic databases

PaxDbⁱ	O35227
PRIDEⁱ	O35227

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11500
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056
GeneIDⁱ	11500
KEGGⁱ	mmu:11500
UCSCⁱ	uc007ulr.1 mouse

Organism-specific databases

CTDⁱ	8756
MGIⁱ	MGI:107247 Adam7

Phylogenomic databases

eggNOGⁱ	KOG3607 Eukaryota ENOG410XX2M LUCA
GeneTreeⁱ	ENSGT00910000144014
HOGENOMⁱ	HOG000230883
HOVERGENⁱ	HBG006978
InParanoidⁱ	O35227
KOⁱ	K16071
OMAⁱ	MDHCFYQ
OrthoDBⁱ	EOG091G01NX
TreeFamⁱ	TF314733

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O35227
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022056 Expressed in 29 organ(s), highest expression level in epididymal fat pad
CleanExⁱ	MM_ADAM7
Genevisibleⁱ	O35227 MM

Family and domain databases

CDDⁱ	cd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Dⁱ	3.40.390.10, 1 hit 4.10.70.10, 1 hit
InterProⁱ	View protein in InterPro IPR006586 ADAM_Cys-rich IPR018358 Disintegrin_CS IPR001762 Disintegrin_dom IPR036436 Disintegrin_dom_sf IPR024079 MetalloPept_cat_dom_sf IPR001590 Peptidase_M12B IPR002870 Peptidase_M12B_N IPR034027 Reprolysin_adamalysin
Pfamⁱ	View protein in Pfam PF08516 ADAM_CR, 1 hit PF00200 Disintegrin, 1 hit PF01562 Pep_M12B_propep, 1 hit PF01421 Reprolysin, 1 hit
PRINTSⁱ	PR00289 DISINTEGRIN
SMARTⁱ	View protein in SMART SM00608 ACR, 1 hit SM00050 DISIN, 1 hit
SUPFAMⁱ	SSF57552 SSF57552, 1 hit
PROSITEⁱ	View protein in PROSITE PS50215 ADAM_MEPRO, 1 hit PS00427 DISINTEGRIN_1, 1 hit PS50214 DISINTEGRIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADAM7_MOUSE
Accessionⁱ	O35227Primary (citable) accession number: O35227 Secondary accession number(s): F8VQC6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
	Last sequence update:	October 3, 2012
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O35227 (ADAM7_MOUSE)

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Disintegrin and metalloproteinase domain-containing protein 7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ