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Protein

Disintegrin and metalloproteinase domain-containing protein 7

Gene

Adam7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  • endopeptidase activity Source: MGI
  • metalloendopeptidase activity Source: InterPro

Protein family/group databases

MEROPSiM12.956

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 7
Short name:
ADAM 7
Gene namesi
Name:Adam7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:107247 Adam7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 667ExtracellularSequence analysisAdd BLAST644
Transmembranei668 – 689HelicalSequence analysisAdd BLAST22
Topological domaini690 – 789CytoplasmicSequence analysisAdd BLAST100

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000041968124 – 176By similarityAdd BLAST153
ChainiPRO_0000029056177 – 789Disintegrin and metalloproteinase domain-containing protein 7Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi310 ↔ 388By similarity
Disulfide bondi350 ↔ 372By similarity
Disulfide bondi352 ↔ 357By similarity
Disulfide bondi459 ↔ 479By similarity
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi664N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35227
PRIDEiO35227

PTM databases

PhosphoSitePlusiO35227

Expressioni

Tissue specificityi

Expressed in the apical region of the proximal caput epididymal epithelium and in the anterior pituitary, specifically, in the gonadotrophes.

Gene expression databases

BgeeiENSMUSG00000022056 Expressed in 29 organ(s), highest expression level in epididymal fat pad
CleanExiMM_ADAM7
GenevisibleiO35227 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022640

Structurei

3D structure databases

ProteinModelPortaliO35227
SMRiO35227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 393Peptidase M12BPROSITE-ProRule annotationAdd BLAST195
Domaini401 – 487DisintegrinPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi488 – 667Cys-richAdd BLAST180

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144014
HOGENOMiHOG000230883
HOVERGENiHBG006978
InParanoidiO35227
KOiK16071
OMAiMDHCFYQ
OrthoDBiEOG091G01NX
TreeFamiTF314733

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTTGIFWMT VLISHIQERG IVGVEGQELV HPKKLPLLHK RDLERIHDSD
60 70 80 90 100
IPEEYEEELL YEIKLGKKTL ILHLLKAREF LSSNYSETYY NVKREVFTKH
110 120 130 140 150
PQILDHCFYQ GSIIHEFDSA ASISTCNGLR GFFRVNDQRY LIEPVKYSDD
160 170 180 190 200
GEHLVYKYNV KAPYATNHSC VGLNFTKKSA LIDVENIEEH NAEDHHKEKF
210 220 230 240 250
IELFVVADEY VYRRNNKPQN KLRKRIWGMV NFVNMIYKTL NIHVTLAGFE
260 270 280 290 300
IWSAGDKIEI VSNLESTLLH FSTWQETVLK KRKDFDHVIL LSGKWLYTSM
310 320 330 340 350
QGIAYPGGIC QILRSCSVVK DLLPDVNIIG NRMAHQLGHS LGMQHDGFPC
360 370 380 390 400
TCPLGKCVMG DGSIPAIKFS KCSQTQYQQF LQDQKPACIL NNPFPEEFND
410 420 430 440 450
YPFCGNKKVD EGEECDCGPV QECTNPCCDA HKCVLKPGFT CVEGECCESC
460 470 480 490 500
QMKKEGAVCR LAKNECDISE VCTGYSPECP KDEFQANGFP CRNGEGYCFM
510 520 530 540 550
GLCPTRNEQC SELFIGGAEE SHSLCYRMNK KGNRFGYCKN KGNTFVPCEE
560 570 580 590 600
KDLKCGKIYC SGGRPSSRLG EDKAYNLKNV KQNVTIKCRT MFLHHNSRDM
610 620 630 640 650
GLVNSGTKCG DGMVCSNGEC IEMEKAYNST ICSSPCDEND VDDNEPECQC
660 670 680 690 700
EEGSIITEWG EALNLTSVSI MVIVLVMVII GVGLVILLIR YQKCIKMKQV
710 720 730 740 750
QSSPREIRGV ENKGYFPEEH QTRSEPILTD IHPLHTTAES LERVPSSFSS
760 770 780
PHYITLKSVS KDSRGIADPK QTDNVNLNLD TQSGCERLG
Length:789
Mass (Da):89,188
Last modified:October 3, 2012 - v2
Checksum:i9C14BAE5D589AF76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3LT → FP in AAC53368 (PubMed:9322939).Curated2
Sequence conflicti8W → L in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti28E → Q in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti155V → M in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti224 – 225KR → NG in AAC53368 (PubMed:9322939).Curated2
Sequence conflicti253S → L in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti397E → K in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti414E → K in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti495E → K in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti572 – 574DKA → NKT in AAC53368 (PubMed:9322939).Curated3
Sequence conflicti679Missing in AAC53368 (PubMed:9322939).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013107 mRNA Translation: AAC53368.1
AC154706 Genomic DNA No translation available.
CCDSiCCDS27234.1
RefSeqiNP_031428.2, NM_007402.2
UniGeneiMm.261495

Genome annotation databases

EnsembliENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056
GeneIDi11500
KEGGimmu:11500
UCSCiuc007ulr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013107 mRNA Translation: AAC53368.1
AC154706 Genomic DNA No translation available.
CCDSiCCDS27234.1
RefSeqiNP_031428.2, NM_007402.2
UniGeneiMm.261495

3D structure databases

ProteinModelPortaliO35227
SMRiO35227
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022640

Protein family/group databases

MEROPSiM12.956

PTM databases

PhosphoSitePlusiO35227

Proteomic databases

PaxDbiO35227
PRIDEiO35227

Protocols and materials databases

DNASUi11500
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056
GeneIDi11500
KEGGimmu:11500
UCSCiuc007ulr.1 mouse

Organism-specific databases

CTDi8756
MGIiMGI:107247 Adam7

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144014
HOGENOMiHOG000230883
HOVERGENiHBG006978
InParanoidiO35227
KOiK16071
OMAiMDHCFYQ
OrthoDBiEOG091G01NX
TreeFamiTF314733

Miscellaneous databases

PROiPR:O35227
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022056 Expressed in 29 organ(s), highest expression level in epididymal fat pad
CleanExiMM_ADAM7
GenevisibleiO35227 MM

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADAM7_MOUSE
AccessioniPrimary (citable) accession number: O35227
Secondary accession number(s): F8VQC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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