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Protein

Cleavage and polyadenylation specificity factor subunit 2

Gene

Cpsf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing
R-MMU-77595 Processing of Intronless Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage and polyadenylation specificity factor subunit 2
Alternative name(s):
Cleavage and polyadenylation specificity factor 100 kDa subunit
Short name:
CPSF 100 kDa subunit
Gene namesi
Name:Cpsf2
Synonyms:Cpsf100, Mcpsf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1861601 Cpsf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743941 – 782Cleavage and polyadenylation specificity factor subunit 2Add BLAST782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei419PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei660PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35218
MaxQBiO35218
PaxDbiO35218
PeptideAtlasiO35218
PRIDEiO35218

PTM databases

iPTMnetiO35218
PhosphoSitePlusiO35218

Expressioni

Gene expression databases

BgeeiENSMUSG00000041781 Expressed in 276 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CPSF2
GenevisibleiO35218 MM

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with CPSF3, CSTF2 and SYMPK (By similarity). Interacts with ZC3H3 (PubMed:16115198).By similarity1 Publication

Protein-protein interaction databases

BioGridi206172, 4 interactors
IntActiO35218, 2 interactors
MINTiO35218
STRINGi10090.ENSMUSP00000047797

Structurei

3D structure databases

ProteinModelPortaliO35218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1135 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00910000144260
HOGENOMiHOG000264343
HOVERGENiHBG051106
InParanoidiO35218
KOiK14402
OMAiWKNKESG
OrthoDBiEOG091G03GG
PhylomeDBiO35218
TreeFamiTF106131

Family and domain databases

CDDicd16293 CPSF2-like_MBL-fold, 1 hit
Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR022712 Beta_Casp
IPR027075 CPSF2
IPR025069 Cpsf2_C
IPR035639 CPSF2_MBL
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR011108 RMMBL
PANTHERiPTHR11203:SF5 PTHR11203:SF5, 1 hit
PfamiView protein in Pfam
PF10996 Beta-Casp, 1 hit
PF13299 CPSF100_C, 1 hit
PF16661 Lactamase_B_6, 1 hit
PF07521 RMMBL, 1 hit
SMARTiView protein in SMART
SM01027 Beta-Casp, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

Sequencei

Sequence statusi: Complete.

O35218-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIIKLTTL SGVQEESALC YLLQVDEFRF LLDCGWDEHF SVDIIDSLRK
60 70 80 90 100
HVHQIDAVLL SHPDPLHLGA LPFAVGKLGL NCAIYATIPV YKMGQMFMYD
110 120 130 140 150
LYQSRHNTED FTLFTLDDVD AAFDKIQQLK FSQIVNLKGK GHGLSITPLP
160 170 180 190 200
AGHMIGGTIW KIVKDGEEEI VYAVDFNHKR EIHLNGCSLE MLSRPSLLIT
210 220 230 240 250
DSFNATYVQP RRKQRDEQLL TNVLETLRGD GNVLIAVDTA GRVLELAQLL
260 270 280 290 300
DQIWRTKDAG LGVYSLALLN NVSYNVVEFS KSQVEWMSDK LMRCFEDKRN
310 320 330 340 350
NPFQFRHLSL CHGLSDLARV PSPKVVLASQ PDLECGFSRD LFIQWCQDPK
360 370 380 390 400
NSIILTYRTT PGTLARFLID NPTEKVTEIE LRKRVKLEGK ELEEYVEKEK
410 420 430 440 450
LKKEAAKKLE QSKEADIDSS DESDVEEDVD QPSAHKTKHD LMMKGEGSRK
460 470 480 490 500
GSFFKQAKKS YPMFPAPEER IKWDEYGEII KPEDFLVPEL QATEEEKSKL
510 520 530 540 550
ESGLTNGEEP MDQDLSDVPT KCVSATESIE IKARVTYIDY EGRSDGDSIK
560 570 580 590 600
KIINQMKPRQ LIIVHGPPEA SQDLAECCRA FGGKDIKVYM PKLHETVDAT
610 620 630 640 650
SETHIYQVRL KDSLVSSLQF CKAKDAELAW IDGVLDMRVS KVDTGVILEE
660 670 680 690 700
GELKDDGEDS EMQVDAPSDS SAMAQQKAMK SLFGEDEKEL GEETEIIPTL
710 720 730 740 750
EPLPPHEVPG HQSVFMNEPR LSDFKQVLLR EGIQAEFVGG VLVCNNQVAV
760 770 780
RRTETGRIGL EGCLCQDFYR IRDLLYEQYA IV
Length:782
Mass (Da):88,383
Last modified:January 1, 1998 - v1
Checksum:i5F60DBB9DEDEBB4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012822 mRNA Translation: AAB66830.1
BC013628 mRNA Translation: AAH13628.1
BC007163 mRNA Translation: AAH07163.1
CCDSiCCDS26116.1
RefSeqiNP_058552.1, NM_016856.3
XP_006516134.1, XM_006516071.3
UniGeneiMm.716

Genome annotation databases

EnsembliENSMUST00000047357; ENSMUSP00000047797; ENSMUSG00000041781
GeneIDi51786
KEGGimmu:51786
UCSCiuc007otx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012822 mRNA Translation: AAB66830.1
BC013628 mRNA Translation: AAH13628.1
BC007163 mRNA Translation: AAH07163.1
CCDSiCCDS26116.1
RefSeqiNP_058552.1, NM_016856.3
XP_006516134.1, XM_006516071.3
UniGeneiMm.716

3D structure databases

ProteinModelPortaliO35218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206172, 4 interactors
IntActiO35218, 2 interactors
MINTiO35218
STRINGi10090.ENSMUSP00000047797

PTM databases

iPTMnetiO35218
PhosphoSitePlusiO35218

Proteomic databases

EPDiO35218
MaxQBiO35218
PaxDbiO35218
PeptideAtlasiO35218
PRIDEiO35218

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047357; ENSMUSP00000047797; ENSMUSG00000041781
GeneIDi51786
KEGGimmu:51786
UCSCiuc007otx.2 mouse

Organism-specific databases

CTDi53981
MGIiMGI:1861601 Cpsf2

Phylogenomic databases

eggNOGiKOG1135 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00910000144260
HOGENOMiHOG000264343
HOVERGENiHBG051106
InParanoidiO35218
KOiK14402
OMAiWKNKESG
OrthoDBiEOG091G03GG
PhylomeDBiO35218
TreeFamiTF106131

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing
R-MMU-77595 Processing of Intronless Pre-mRNAs

Miscellaneous databases

PROiPR:O35218
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041781 Expressed in 276 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CPSF2
GenevisibleiO35218 MM

Family and domain databases

CDDicd16293 CPSF2-like_MBL-fold, 1 hit
Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR022712 Beta_Casp
IPR027075 CPSF2
IPR025069 Cpsf2_C
IPR035639 CPSF2_MBL
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR011108 RMMBL
PANTHERiPTHR11203:SF5 PTHR11203:SF5, 1 hit
PfamiView protein in Pfam
PF10996 Beta-Casp, 1 hit
PF13299 CPSF100_C, 1 hit
PF16661 Lactamase_B_6, 1 hit
PF07521 RMMBL, 1 hit
SMARTiView protein in SMART
SM01027 Beta-Casp, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPSF2_MOUSE
AccessioniPrimary (citable) accession number: O35218
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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