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Protein

D-dopachrome decarboxylase

Gene

Ddt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).By similarity

Catalytic activityi

D-dopachrome = 5,6-dihydroxyindole + CO2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processMelanin biosynthesis

Enzyme and pathway databases

BRENDAi4.1.1.84 3474

Names & Taxonomyi

Protein namesi
Recommended name:
D-dopachrome decarboxylase (EC:4.1.1.84)
Alternative name(s):
D-dopachrome tautomerase
Gene namesi
Name:Ddt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1298381 Ddt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001580712 – 118D-dopachrome decarboxylaseAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylproline1 Publication1
Modified residuei33N6-acetyllysineCombined sources1
Modified residuei90PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35215
PaxDbiO35215
PeptideAtlasiO35215
PRIDEiO35215

2D gel databases

REPRODUCTION-2DPAGEiO35215
SWISS-2DPAGEiO35215
UCD-2DPAGEiO35215

PTM databases

iPTMnetiO35215
PhosphoSitePlusiO35215
SwissPalmiO35215

Expressioni

Gene expression databases

BgeeiENSMUSG00000001666 Expressed in 27 organ(s), highest expression level in liver
CleanExiMM_DDT
ExpressionAtlasiO35215 baseline and differential
GenevisibleiO35215 MM

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35215, 1 interactor
MINTiO35215
STRINGi10090.ENSMUSP00000001716

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO35215
SMRiO35215
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35215

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759 Eukaryota
ENOG41122MF LUCA
GeneTreeiENSGT00930000150952
HOGENOMiHOG000112325
HOVERGENiHBG003240
InParanoidiO35215
KOiK10028
OMAiFFPLEPW
OrthoDBiEOG091G0ZNJ
PhylomeDBiO35215
TreeFamiTF313853

Family and domain databases

Gene3Di3.30.429.10, 1 hit
InterProiView protein in InterPro
IPR001398 Macrophage_inhib_fac
IPR019829 Macrophage_inhib_fac_CS
IPR014347 Tautomerase/MIF_sf
PANTHERiPTHR11954 PTHR11954, 1 hit
PfamiView protein in Pfam
PF01187 MIF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004816 Macrophage_inhib_fac, 1 hit
SUPFAMiSSF55331 SSF55331, 1 hit
PROSITEiView protein in PROSITE
PS01158 MIF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35215-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM
60 70 80 90 100
NKSTEPCAHL LVSSIGVVGT AEQNRTHSAS FFKFLTEELS LDQDRIVIRF
110
FPLEAWQIGK KGTVMTFL
Length:118
Mass (Da):13,077
Last modified:January 23, 2007 - v3
Checksum:i0440692D5413FC81
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZN1G3UZN1_MOUSE
D-dopachrome decarboxylase
Ddt
73Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012431 Genomic DNA Translation: AAC77467.1
AF068199 Genomic DNA Translation: AAC32825.1
BC010753 mRNA Translation: AAH10753.1
CCDSiCCDS23930.1
RefSeqiNP_034157.1, NM_010027.1
UniGeneiMm.298947

Genome annotation databases

EnsembliENSMUST00000001716; ENSMUSP00000001716; ENSMUSG00000001666
GeneIDi13202
KEGGimmu:13202
UCSCiuc007fra.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012431 Genomic DNA Translation: AAC77467.1
AF068199 Genomic DNA Translation: AAC32825.1
BC010753 mRNA Translation: AAH10753.1
CCDSiCCDS23930.1
RefSeqiNP_034157.1, NM_010027.1
UniGeneiMm.298947

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KERX-ray2.78A/B/C/D2-118[»]
ProteinModelPortaliO35215
SMRiO35215
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35215, 1 interactor
MINTiO35215
STRINGi10090.ENSMUSP00000001716

PTM databases

iPTMnetiO35215
PhosphoSitePlusiO35215
SwissPalmiO35215

2D gel databases

REPRODUCTION-2DPAGEiO35215
SWISS-2DPAGEiO35215
UCD-2DPAGEiO35215

Proteomic databases

EPDiO35215
PaxDbiO35215
PeptideAtlasiO35215
PRIDEiO35215

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001716; ENSMUSP00000001716; ENSMUSG00000001666
GeneIDi13202
KEGGimmu:13202
UCSCiuc007fra.1 mouse

Organism-specific databases

CTDi1652
MGIiMGI:1298381 Ddt

Phylogenomic databases

eggNOGiKOG1759 Eukaryota
ENOG41122MF LUCA
GeneTreeiENSGT00930000150952
HOGENOMiHOG000112325
HOVERGENiHBG003240
InParanoidiO35215
KOiK10028
OMAiFFPLEPW
OrthoDBiEOG091G0ZNJ
PhylomeDBiO35215
TreeFamiTF313853

Enzyme and pathway databases

BRENDAi4.1.1.84 3474

Miscellaneous databases

EvolutionaryTraceiO35215
PROiPR:O35215
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001666 Expressed in 27 organ(s), highest expression level in liver
CleanExiMM_DDT
ExpressionAtlasiO35215 baseline and differential
GenevisibleiO35215 MM

Family and domain databases

Gene3Di3.30.429.10, 1 hit
InterProiView protein in InterPro
IPR001398 Macrophage_inhib_fac
IPR019829 Macrophage_inhib_fac_CS
IPR014347 Tautomerase/MIF_sf
PANTHERiPTHR11954 PTHR11954, 1 hit
PfamiView protein in Pfam
PF01187 MIF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004816 Macrophage_inhib_fac, 1 hit
SUPFAMiSSF55331 SSF55331, 1 hit
PROSITEiView protein in PROSITE
PS01158 MIF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDOPD_MOUSE
AccessioniPrimary (citable) accession number: O35215
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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