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Protein

Visual pigment-like receptor peropsin

Gene

Rrh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

GO - Molecular functioni

  • G protein-coupled photoreceptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process
LigandChromophore

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Visual pigment-like receptor peropsin
Gene namesi
Name:Rrh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1097709 Rrh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularAdd BLAST26
Transmembranei27 – 49Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini50 – 61CytoplasmicAdd BLAST12
Transmembranei62 – 87Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini88 – 101ExtracellularAdd BLAST14
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicAdd BLAST19
Transmembranei141 – 164Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini165 – 188ExtracellularAdd BLAST24
Transmembranei189 – 212Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini213 – 240CytoplasmicAdd BLAST28
Transmembranei241 – 264Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini265 – 272Extracellular8
Transmembranei273 – 297Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini298 – 337CytoplasmicAdd BLAST40

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978201 – 337Visual pigment-like receptor peropsinAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei284N6-(retinylidene)lysine1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35214
PRIDEiO35214

PTM databases

iPTMnetiO35214
PhosphoSitePlusiO35214

Expressioni

Tissue specificityi

Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.

Gene expression databases

BgeeiENSMUSG00000028012 Expressed in 37 organ(s), highest expression level in camera-type eye
ExpressionAtlasiO35214 baseline and differential
GenevisibleiO35214 MM

Interactioni

Protein-protein interaction databases

BioGridi203021, 1 interactor
STRINGi10090.ENSMUSP00000029648

Structurei

3D structure databases

ProteinModelPortaliO35214
SMRiO35214
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000115897
HOVERGENiHBG098035
InParanoidiO35214
KOiK04253
OMAiAGCQIYA
PhylomeDBiO35214
TreeFamiTF324998

Family and domain databases

CDDicd15073 7tmA_Peropsin, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002962 Peropsin
IPR027430 Retinal_BS
IPR032972 RRH
PANTHERiPTHR24240:SF77 PTHR24240:SF77, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01244 PEROPSIN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O35214-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSEASDFNS SGSRSEGSVF SRTEHSVIAA YLIVAGITSI LSNVVVLGIF
60 70 80 90 100
IKYKELRTPT NAVIINLAFT DIGVSSIGYP MSAASDLHGS WKFGHAGCQI
110 120 130 140 150
YAGLNIFFGM VSIGLLTVVA MDRYLTISCP DVGRRMTTNT YLSMILGAWI
160 170 180 190 200
NGLFWALMPI IGWASYAPDP TGATCTINWR NNDTSFVSYT MMVIVVNFIV
210 220 230 240 250
PLTVMFYCYY HVSRSLRLYA ASDCTAHLHR DWADQADVTK MSVIMILMFL
260 270 280 290 300
LAWSPYSIVC LWACFGNPKK IPPSMAIIAP LFAKSSTFYN PCIYVAAHKK
310 320 330
FRKAMLAMFK CQPHLAVPEP STLPMDMPQS SLAPVRI
Length:337
Mass (Da):37,209
Last modified:January 1, 1998 - v1
Checksum:i353E4E2278EDBFA6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80XL3Q80XL3_MOUSE
Rrh protein
Rrh
379Annotation score:
A0A0G2JF76A0A0G2JF76_MOUSE
Retinal pigment epithelium derived ...
Rrh mCG_5265
240Annotation score:
A0A0G2JFN6A0A0G2JFN6_MOUSE
Visual pigment-like receptor perops...
Rrh
130Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012271 mRNA Translation: AAC53344.1
CCDSiCCDS38633.1
RefSeqiNP_033128.1, NM_009102.3
UniGeneiMm.278758

Genome annotation databases

EnsembliENSMUST00000171313; ENSMUSP00000132360; ENSMUSG00000028012
ENSMUST00000196902; ENSMUSP00000143093; ENSMUSG00000028012
GeneIDi20132
KEGGimmu:20132
UCSCiuc008ril.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012271 mRNA Translation: AAC53344.1
CCDSiCCDS38633.1
RefSeqiNP_033128.1, NM_009102.3
UniGeneiMm.278758

3D structure databases

ProteinModelPortaliO35214
SMRiO35214
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203021, 1 interactor
STRINGi10090.ENSMUSP00000029648

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO35214
PhosphoSitePlusiO35214

Proteomic databases

PaxDbiO35214
PRIDEiO35214

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171313; ENSMUSP00000132360; ENSMUSG00000028012
ENSMUST00000196902; ENSMUSP00000143093; ENSMUSG00000028012
GeneIDi20132
KEGGimmu:20132
UCSCiuc008ril.1 mouse

Organism-specific databases

CTDi10692
MGIiMGI:1097709 Rrh

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000115897
HOVERGENiHBG098035
InParanoidiO35214
KOiK04253
OMAiAGCQIYA
PhylomeDBiO35214
TreeFamiTF324998

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Miscellaneous databases

PROiPR:O35214
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028012 Expressed in 37 organ(s), highest expression level in camera-type eye
ExpressionAtlasiO35214 baseline and differential
GenevisibleiO35214 MM

Family and domain databases

CDDicd15073 7tmA_Peropsin, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002962 Peropsin
IPR027430 Retinal_BS
IPR032972 RRH
PANTHERiPTHR24240:SF77 PTHR24240:SF77, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01244 PEROPSIN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPSX_MOUSE
AccessioniPrimary (citable) accession number: O35214
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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