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Protein

Cyclin-dependent kinase 2-associated protein 1

Gene

Cdk2ap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

specific inhibitor of the cell-cycle kinase CDK2.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • face morphogenesis Source: MGI
  • in utero embryonic development Source: MGI
  • positive regulation of protein phosphorylation Source: MGI

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 1
Short name:
CDK2-associated protein 1
Alternative name(s):
Deleted in oral cancer 1
Short name:
DOC-1
Putative oral cancer suppressor
Gene namesi
Name:Cdk2ap1
Synonyms:Cdkap1, Doc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 11, Chromosome 5

Organism-specific databases

MGIiMGI:1202069 Cdk2ap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894541 – 114Cyclin-dependent kinase 2-associated protein 1Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45Phosphoserine; by IKKEBy similarity1
Disulfide bondi104InterchainSequence analysis

Post-translational modificationi

Phosphorylated in vitro by IKBKE at Ser-45.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO35207
MaxQBiO35207
PaxDbiO35207
PeptideAtlasiO35207
PRIDEiO35207

PTM databases

PhosphoSitePlusiO35207

Expressioni

Gene expression databases

BgeeiENSMUSG00000029394 Expressed in 35 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiO35207 baseline and differential
GenevisibleiO35207 MM

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with monomeric unphosphorylated CDK2 (PubMed:10938106). Interacts with CDK2AP2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199264, 13 interactors
IntActiO35207, 13 interactors
STRINGi10090.ENSMUSP00000100565

Structurei

3D structure databases

ProteinModelPortaliO35207
SMRiO35207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 60Intrinsically disorderedBy similarityAdd BLAST60
Regioni19 – 24Interaction with CDK2AP2By similarity6

Sequence similaritiesi

Belongs to the CDK2AP family.Curated

Phylogenomic databases

eggNOGiKOG4713 Eukaryota
ENOG41126TJ LUCA
GeneTreeiENSGT00390000006964
HOGENOMiHOG000035115
HOVERGENiHBG002074
InParanoidiO35207
OMAiISDGHIC
OrthoDBiEOG091G1364
PhylomeDBiO35207
TreeFamiTF101037

Family and domain databases

InterProiView protein in InterPro
IPR017266 DOC_1/2
PANTHERiPTHR22607 PTHR22607, 1 hit
PfamiView protein in Pfam
PF09806 CDK2AP, 1 hit
PIRSFiPIRSF037709 CDK2-associated_p2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35207-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYKPNLTAH MPAAALNAGS VHSPSTSMAT SSQYRQLLSD YGPPSLGYTQ
60 70 80 90 100
GTGNSQVPQS KYAELLAIIE ELGKEIRPTY AGSKSAMERL KRGIIHARSL
110
VRECLAETER NARS
Length:114
Mass (Da):12,354
Last modified:August 16, 2005 - v2
Checksum:i6421DD87E438F02D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z4B3F2Z4B3_MOUSE
Cyclin-dependent kinase 2-associate...
Cdk2ap1
87Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004852 mRNA Translation: BAB23616.1
AL645849 Genomic DNA Translation: CAI35111.1
BC083075 mRNA Translation: AAH83075.1
BC103772 mRNA Translation: AAI03773.1
BC147052 mRNA Translation: AAI47053.1
BC147053 mRNA Translation: AAI47054.1
AF011644 mRNA Translation: AAB65752.1
CCDSiCCDS39279.1
RefSeqiNP_038840.2, NM_013812.2
UniGeneiMm.391838
Mm.425284

Genome annotation databases

EnsembliENSMUST00000031341; ENSMUSP00000031341; ENSMUSG00000029394
ENSMUST00000104959; ENSMUSP00000100565; ENSMUSG00000078154
GeneIDi13445
KEGGimmu:13445
UCSCiuc008zpo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004852 mRNA Translation: BAB23616.1
AL645849 Genomic DNA Translation: CAI35111.1
BC083075 mRNA Translation: AAH83075.1
BC103772 mRNA Translation: AAI03773.1
BC147052 mRNA Translation: AAI47053.1
BC147053 mRNA Translation: AAI47054.1
AF011644 mRNA Translation: AAB65752.1
CCDSiCCDS39279.1
RefSeqiNP_038840.2, NM_013812.2
UniGeneiMm.391838
Mm.425284

3D structure databases

ProteinModelPortaliO35207
SMRiO35207
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199264, 13 interactors
IntActiO35207, 13 interactors
STRINGi10090.ENSMUSP00000100565

PTM databases

PhosphoSitePlusiO35207

Proteomic databases

EPDiO35207
MaxQBiO35207
PaxDbiO35207
PeptideAtlasiO35207
PRIDEiO35207

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031341; ENSMUSP00000031341; ENSMUSG00000029394
ENSMUST00000104959; ENSMUSP00000100565; ENSMUSG00000078154
GeneIDi13445
KEGGimmu:13445
UCSCiuc008zpo.1 mouse

Organism-specific databases

CTDi8099
MGIiMGI:1202069 Cdk2ap1

Phylogenomic databases

eggNOGiKOG4713 Eukaryota
ENOG41126TJ LUCA
GeneTreeiENSGT00390000006964
HOGENOMiHOG000035115
HOVERGENiHBG002074
InParanoidiO35207
OMAiISDGHIC
OrthoDBiEOG091G1364
PhylomeDBiO35207
TreeFamiTF101037

Miscellaneous databases

ChiTaRSiCar6 mouse
PROiPR:O35207
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029394 Expressed in 35 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiO35207 baseline and differential
GenevisibleiO35207 MM

Family and domain databases

InterProiView protein in InterPro
IPR017266 DOC_1/2
PANTHERiPTHR22607 PTHR22607, 1 hit
PfamiView protein in Pfam
PF09806 CDK2AP, 1 hit
PIRSFiPIRSF037709 CDK2-associated_p2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDKA1_MOUSE
AccessioniPrimary (citable) accession number: O35207
Secondary accession number(s): B2RV53, Q3SYK3, Q6ZWZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 16, 2005
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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