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Protein

Granzyme K

Gene

Gzmk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Charge relay systemBy similarity1
Active sitei115Charge relay systemBy similarity1
Active sitei213Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B4 3474

Protein family/group databases

MEROPSiS01.146

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme K (EC:3.4.21.-)
Gene namesi
Name:Gzmk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1298232 Gzmk

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002741722 – 25Activation peptide4
ChainiPRO_000002741826 – 263Granzyme KAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 67PROSITE-ProRule annotation
Disulfide bondi148 ↔ 219PROSITE-ProRule annotation
Disulfide bondi180 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 233PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiO35205
PRIDEiO35205

PTM databases

iPTMnetiO35205
PhosphoSitePlusiO35205

Expressioni

Gene expression databases

BgeeiENSMUSG00000042385 Expressed in 57 organ(s), highest expression level in hypothalamus
CleanExiMM_GZMK
ExpressionAtlasiO35205 baseline and differential
GenevisibleiO35205 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044512

Structurei

3D structure databases

ProteinModelPortaliO35205
SMRiO35205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiO35205
KOiK08663
OMAiNMEIIGG
OrthoDBiEOG091G0AH5
PhylomeDBiO35205
TreeFamiTF333630

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35205-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFSSWALVS LVAGVYMSSE CFHTEIIGGR EVQPHSRPFM ASIQYRSKHI
60 70 80 90 100
CGGVLIHPQW VLTAAHCYSW FPRGHSPTVV LGAHSLSKNE PMKQTFEIKK
110 120 130 140 150
FIPFSRLQSG SASHDIMLIK LRTAAELNKN VQLLHLGSKN YLRDGTKCQV
160 170 180 190 200
TGWGTTKPDL LTASDTLREV TVTIISRKRC NSQSYYNHKP VITKDMICAG
210 220 230 240 250
DARGQKDSCK GDSGGPLICK GIFHALVSQG YKCGIAKKPG IYTLLTKKYQ
260
TWIKSKLAPS RAH
Length:263
Mass (Da):29,251
Last modified:January 1, 1998 - v1
Checksum:i81951594F9AF08DE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RE36D6RE36_MOUSE
Granzyme K
Gzmk
69Annotation score:
D3Z594D3Z594_MOUSE
Granzyme K
Gzmk
224Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011446 Genomic DNA Translation: AAC17930.1
CCDSiCCDS26783.1
RefSeqiNP_032222.1, NM_008196.1
UniGeneiMm.56993

Genome annotation databases

EnsembliENSMUST00000038212; ENSMUSP00000044512; ENSMUSG00000042385
GeneIDi14945
KEGGimmu:14945
UCSCiuc007rxd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011446 Genomic DNA Translation: AAC17930.1
CCDSiCCDS26783.1
RefSeqiNP_032222.1, NM_008196.1
UniGeneiMm.56993

3D structure databases

ProteinModelPortaliO35205
SMRiO35205
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044512

Protein family/group databases

MEROPSiS01.146

PTM databases

iPTMnetiO35205
PhosphoSitePlusiO35205

Proteomic databases

PaxDbiO35205
PRIDEiO35205

Protocols and materials databases

DNASUi14945
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038212; ENSMUSP00000044512; ENSMUSG00000042385
GeneIDi14945
KEGGimmu:14945
UCSCiuc007rxd.1 mouse

Organism-specific databases

CTDi3003
MGIiMGI:1298232 Gzmk

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiO35205
KOiK08663
OMAiNMEIIGG
OrthoDBiEOG091G0AH5
PhylomeDBiO35205
TreeFamiTF333630

Enzyme and pathway databases

BRENDAi3.4.21.B4 3474

Miscellaneous databases

PROiPR:O35205
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042385 Expressed in 57 organ(s), highest expression level in hypothalamus
CleanExiMM_GZMK
ExpressionAtlasiO35205 baseline and differential
GenevisibleiO35205 MM

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRAK_MOUSE
AccessioniPrimary (citable) accession number: O35205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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