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Protein

Cathepsin K

Gene

Ctsk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity).By similarity

Catalytic activityi

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei139By similarity1
Active sitei276By similarity1
Active sitei296By similarity1

GO - Molecular functioni

GO - Biological processi

  • bone resorption Source: RGD
  • collagen catabolic process Source: Ensembl
  • intramembranous ossification Source: RGD
  • proteolysis Source: RGD
  • proteolysis involved in cellular protein catabolic process Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.38 5301
ReactomeiR-RNO-1442490 Collagen degradation
R-RNO-1474228 Degradation of the extracellular matrix
R-RNO-1592389 Activation of Matrix Metalloproteinases
R-RNO-1679131 Trafficking and processing of endosomal TLR
R-RNO-2132295 MHC class II antigen presentation
R-RNO-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Protein family/group databases

MEROPSiI29.007

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin K (EC:3.4.22.38)
Gene namesi
Name:Ctsk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi61810 Ctsk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3034

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
PropeptideiPRO_000002630716 – 114Activation peptideAdd BLAST99
ChainiPRO_0000026308115 – 329Cathepsin KAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 177By similarity
Disulfide bondi170 ↔ 210By similarity
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 318By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO35186
PRIDEiO35186

PTM databases

iPTMnetiO35186
PhosphoSitePlusiO35186

Expressioni

Gene expression databases

BgeeiENSRNOG00000021155
GenevisibleiO35186 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028730

Chemistry databases

BindingDBiO35186

Structurei

3D structure databases

ProteinModelPortaliO35186
SMRiO35186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140823
HOGENOMiHOG000230774
HOVERGENiHBG011513
InParanoidiO35186
KOiK01371
OMAiKGNKHWI
OrthoDBiEOG091G0AKT
PhylomeDBiO35186
TreeFamiTF313739

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR015644 Peptidase_C1A_cathepsin-K
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PTHR12411:SF55 PTHR12411:SF55, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVFKFLLLP VVSFALSPEE TLDTQWELWK KTHGKQYNSK VDEISRRLIW
60 70 80 90 100
EKNLKKISVH NLEASLGAHT YELAMNHLGD MTSEEVVQKM TGLRVPPSRS
110 120 130 140 150
FSNDTLYTPE WEGRVPDSID YRKKGYVTPV KNQGQCGSCW AFSSAGALEG
160 170 180 190 200
QLKKKTGKLL ALSPQNLVDC VSENYGCGGG YMTTAFQYVQ QNGGIDSEDA
210 220 230 240 250
YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA RVGPVSVSID
260 270 280 290 300
ASLTSFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGNK YWIIKNSWGE
310 320
SWGNKGYVLL ARNKNNACGI TNLASFPKM
Length:329
Mass (Da):36,791
Last modified:January 1, 1998 - v1
Checksum:iB416008509CF606A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010306 mRNA Translation: AAB65743.1
BC078793 mRNA Translation: AAH78793.1
RefSeqiNP_113748.1, NM_031560.2
UniGeneiRn.5598

Genome annotation databases

EnsembliENSRNOT00000028730; ENSRNOP00000028730; ENSRNOG00000021155
GeneIDi29175
KEGGirno:29175
UCSCiRGD:61810 rat

Similar proteinsi

Entry informationi

Entry nameiCATK_RAT
AccessioniPrimary (citable) accession number: O35186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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