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Protein

Enhancer of filamentation 1

Gene

Nedd9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Cell cycle, Cell division, Growth regulation, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Enhancer of filamentation 1
Short name:
mEF1
Alternative name(s):
CRK-associated substrate-related protein
Short name:
CAS-L
Neural precursor cell expressed developmentally down-regulated protein 9
Short name:
NEDD-9
p105
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nedd9
Synonyms:Casl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97302 Nedd9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000893291 – 833Enhancer of filamentation 1Add BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295PhosphoserineCombined sources1
Modified residuei368PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

PTK2/FAK1 phosphorylates the protein at the YDYVHL motif (conserved among all cas proteins). The SRC family kinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Ligation of either integrin beta-1 or B-cell antigen receptor on tonsillar B-cells and B-cell lines promotes tyrosine phosphorylation and both integrin and BCR-mediated tyrosine phosphorylation requires an intact actin network. In fibroblasts transformation with oncogene v-ABL results in an increase in tyrosine phosphorylation. Transiently phosphorylated following CD3 cross-linking and this phosphorylated form binds to CRK and C3G. A mutant lacking the SH3 domain is phosphorylated upon CD3 cross-linking but not upon integrin beta-1 cross-linking. Tyrosine phosphorylation occurs upon stimulation of the G-protein coupled C1a calcitonin receptor. Calcitonin-stimulated tyrosine phosphorylation is mediated by calcium- and protein kinase C-dependent mechanisms and requires the integrity of the actin cytoskeleton. Phosphorylation at Ser-368 induces proteasomal degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O35177

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O35177

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O35177

PeptideAtlas

More...
PeptideAtlasi
O35177

PRoteomics IDEntifications database

More...
PRIDEi
O35177

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O35177

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O35177

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021365 Expressed in 335 organ(s), highest expression level in cumulus cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O35177 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O35177 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1 (By similarity). Interacts with BCAR3 and SH2D3C.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Sh2d3cQ9QZS82EBI-2642891,EBI-7964037

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201726, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-57058N

Protein interaction database and analysis system

More...
IntActi
O35177, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000021794

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O35177

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O35177

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 65SH3PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni709 – 759Divergent helix-loop-helix motifAdd BLAST51

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi359 – 362Caspase cleavage related siteBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAS family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEDD Eukaryota
ENOG410ZSUM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154002

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004354

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O35177

KEGG Orthology (KO)

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KOi
K16832

Identification of Orthologs from Complete Genome Data

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OMAi
KSWMDDY

Database of Orthologous Groups

More...
OrthoDBi
1086228at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O35177

TreeFam database of animal gene trees

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TreeFami
TF328782

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12002 SH3_NEDD9, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.830, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021901 CAS_C
IPR037362 CAS_fam
IPR035746 NEDD9_SH3
IPR014928 Serine_rich_dom
IPR038319 Serine_rich_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10654 PTHR10654, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12026 CAS_C, 1 hit
PF08824 Serine_rich, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35177-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWARNLMARA LYDNVPECAE ELAFRKGDIL TVIEQNTGGL EGWWLCSLHG
60 70 80 90 100
RQGIVPGNRV KLLIGPVQET PGHEQPTPGP MHQTFGQQKL YQVPNSQAAS
110 120 130 140 150
RDTIYQVPPS YQNQGIYQVP TGHGTPEQDV YQVPPSVQRN IGGTNGPLLS
160 170 180 190 200
KKVITPVRTG HGYVYEYPSR YQKDVYDVPP SHSTQGVYDI PPSSVKGPVF
210 220 230 240 250
SVPVGEIKPQ GVYDIPPTQG VYAIPPSACR DEAGLREKEY DFPPPMKQDG
260 270 280 290 300
KPDTRPEGVY DIPPTSTKTA GKDLHIKFPC DAPGGVEPMA RRHQSFSLHH
310 320 330 340 350
APSQLGQSGD TQSDAYDVPR GVQFLEVPTE TSEKANPEER DGVYDVPLHN
360 370 380 390 400
PADAKGSRDV VDGINRLSFS STGSTRSNMS TSSTSSKESS LSASPSQDKR
410 420 430 440 450
LRLDPDTAIE KLYRLQQTLE MGVCSLMSLV TTDWRCYGYM ERHINEIRTA
460 470 480 490 500
VDKVELFLRE YLHFAKGALA NASCLPELVL HNKMKRELQR VEDSHQILSQ
510 520 530 540 550
TSHDLNECSW SLNILAINKP QNKCDDLDRF VMVAKTVPDD AKQLTTTIST
560 570 580 590 600
YAETLFRADP ANSHLKNGPN SIMNSSEYTH PGSQMQPLHP GDYKAQVHSK
610 620 630 640 650
PLPPSLSKDQ PPDCGSSDGS ERSWMDDYDY VHLQGKEEFE RQQKELLEKE
660 670 680 690 700
NIMKQSKAQL EHHQLSQFQL LEQEITKPVE NDISKWKPSQ SLPTTNNSVG
710 720 730 740 750
AQDRQLLCFY YDQCETHFIS LLNAIDALFS CVSSAQPPRI FVAHSKFVIL
760 770 780 790 800
SAHKLVFIGD TLTRQVAAQD IRNKVRNSSN QLCEQLKTIV MATKMAALHY
810 820 830
PSTTALQEMV HQVTDLSRNA QLFKRSLLEM ATF
Length:833
Mass (Da):93,052
Last modified:June 20, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78AA1B042775DC01
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J212A0A0R4J212_MOUSE
Enhancer of filamentation 1
Nedd9 mCG_10997
833Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCE4A0A286YCE4_MOUSE
Enhancer of filamentation 1
Nedd9
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2 – 4WAR → KYK in BAC35682 (PubMed:16141072).Curated3
Sequence conflicti2 – 4WAR → KYK in BAC32689 (PubMed:16141072).Curated3
Sequence conflicti2 – 4WAR → KYK in BAC28451 (PubMed:16141072).Curated3
Sequence conflicti55V → A in BAC32689 (PubMed:16141072).Curated1
Sequence conflicti126 – 127PE → QN in AAB71663 (Ref. 1) Curated2
Sequence conflicti137V → F in AAB71663 (Ref. 1) Curated1
Sequence conflicti149L → V in BAC32689 (PubMed:16141072).Curated1
Sequence conflicti161H → L in AAB71663 (Ref. 1) Curated1
Sequence conflicti313S → N in BAC27203 (PubMed:16141072).Curated1
Sequence conflicti485K → S in AAB71663 (Ref. 1) Curated1
Sequence conflicti504 – 506DLN → ELD in AAB71663 (Ref. 1) Curated3
Sequence conflicti526D → G in AAB71663 (Ref. 1) Curated1
Sequence conflicti604P → A in BAC35682 (PubMed:16141072).Curated1
Sequence conflicti612P → Q in BAC32689 (PubMed:16141072).Curated1
Sequence conflicti650E → A in AAB71663 (Ref. 1) Curated1
Sequence conflicti685K → R in BAC32689 (PubMed:16141072).Curated1
Sequence conflicti733 – 734SS → TP in AAB71663 (Ref. 1) Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF009366 mRNA Translation: AAB71663.1
AK030985 mRNA Translation: BAC27203.1
AK033729 mRNA Translation: BAC28451.1
AK046357 mRNA Translation: BAC32689.1
AK054179 mRNA Translation: BAC35682.1
AK083374 mRNA Translation: BAC38890.1
BC004696 mRNA Translation: AAH04696.1
BC053713 mRNA Translation: AAH53713.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS49247.1

NCBI Reference Sequences

More...
RefSeqi
NP_001104794.1, NM_001111324.2
NP_059492.3, NM_017464.5

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.288980

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000021794; ENSMUSP00000021794; ENSMUSG00000021365

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18003

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18003

UCSC genome browser

More...
UCSCi
uc007qfd.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009366 mRNA Translation: AAB71663.1
AK030985 mRNA Translation: BAC27203.1
AK033729 mRNA Translation: BAC28451.1
AK046357 mRNA Translation: BAC32689.1
AK054179 mRNA Translation: BAC35682.1
AK083374 mRNA Translation: BAC38890.1
BC004696 mRNA Translation: AAH04696.1
BC053713 mRNA Translation: AAH53713.1
CCDSiCCDS49247.1
RefSeqiNP_001104794.1, NM_001111324.2
NP_059492.3, NM_017464.5
UniGeneiMm.288980

3D structure databases

ProteinModelPortaliO35177
SMRiO35177
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201726, 5 interactors
DIPiDIP-57058N
IntActiO35177, 6 interactors
STRINGi10090.ENSMUSP00000021794

PTM databases

iPTMnetiO35177
PhosphoSitePlusiO35177

Proteomic databases

EPDiO35177
MaxQBiO35177
PaxDbiO35177
PeptideAtlasiO35177
PRIDEiO35177

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021794; ENSMUSP00000021794; ENSMUSG00000021365
GeneIDi18003
KEGGimmu:18003
UCSCiuc007qfd.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4739
MGIiMGI:97302 Nedd9

Phylogenomic databases

eggNOGiENOG410IEDD Eukaryota
ENOG410ZSUM LUCA
GeneTreeiENSGT00940000154002
HOVERGENiHBG004354
InParanoidiO35177
KOiK16832
OMAiKSWMDDY
OrthoDBi1086228at2759
PhylomeDBiO35177
TreeFamiTF328782

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nedd9 mouse

Protein Ontology

More...
PROi
PR:O35177

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021365 Expressed in 335 organ(s), highest expression level in cumulus cell
ExpressionAtlasiO35177 baseline and differential
GenevisibleiO35177 MM

Family and domain databases

CDDicd12002 SH3_NEDD9, 1 hit
Gene3Di1.20.120.830, 1 hit
InterProiView protein in InterPro
IPR021901 CAS_C
IPR037362 CAS_fam
IPR035746 NEDD9_SH3
IPR014928 Serine_rich_dom
IPR038319 Serine_rich_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10654 PTHR10654, 1 hit
PfamiView protein in Pfam
PF12026 CAS_C, 1 hit
PF08824 Serine_rich, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35177
Secondary accession number(s): Q8BJL8
, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 20, 2003
Last modified: January 16, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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