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Protein

Potassium voltage-gated channel subfamily S member 2

Gene

Kcns2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:9305895).1 Publication

GO - Molecular functioni

  • voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 2
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 2
Voltage-gated potassium channel subunit Kv9.2
Gene namesi
Name:Kcns2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1197011 Kcns2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 184CytoplasmicBy similarityAdd BLAST184
Transmembranei185 – 206Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini207 – 225ExtracellularBy similarityAdd BLAST19
Transmembranei226 – 248Helical; Name=Segment S2By similarityAdd BLAST23
Topological domaini249 – 259CytoplasmicBy similarityAdd BLAST11
Transmembranei260 – 280Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini281 – 290ExtracellularBy similarity10
Transmembranei291 – 311Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini312 – 326CytoplasmicBy similarityAdd BLAST15
Transmembranei327 – 348Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini349 – 361ExtracellularBy similarityAdd BLAST13
Intramembranei362 – 373Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei374 – 381By similarity8
Topological domaini382 – 388ExtracellularBy similarity7
Transmembranei389 – 417Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini418 – 477CytoplasmicBy similarityAdd BLAST60

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540851 – 477Potassium voltage-gated channel subfamily S member 2Add BLAST477

Proteomic databases

PaxDbiO35174
PRIDEiO35174

PTM databases

iPTMnetiO35174
PhosphoSitePlusiO35174

Expressioni

Tissue specificityi

Detected in brain, but not in the other tissues tested. Expression was highest in the olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum (PubMed:9305895).1 Publication

Gene expression databases

BgeeiENSMUSG00000050963 Expressed in 96 organ(s), highest expression level in dorsal striatum
CleanExiMM_KCNS2
GenevisibleiO35174 MM

Interactioni

Subunit structurei

Heterotetramer with KCNB1 and KCNB2 (PubMed:9305895). Does not form homomultimers (PubMed:9305895).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072645

Structurei

3D structure databases

ProteinModelPortaliO35174
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi374 – 379Selectivity filterBy similarity6

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG052230
InParanoidiO35174
KOiK04932
OMAiWDESEAN
OrthoDBiEOG091G0FP3
PhylomeDBiO35174
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

O35174-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRQSLWDVS DTDVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH
60 70 80 90 100
SREAILELCD DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS
110 120 130 140 150
FSQEIEYWGI NEFFIDSCCS YSYHGRKVEP EQEKWDEQSD QESTTSSFDE
160 170 180 190 200
ILAFYNDASK FDGQPLGNFR RQLWLALDNP GYSVLSRVFS VLSILVVLGS
210 220 230 240 250
IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF ELVARFAVAP
260 270 280 290 300
DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESSPTLANL GRVAQVLRLM
310 320 330 340 350
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI
360 370 380 390 400
EKEENEGLAT IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL
410 420 430 440 450
VVVLPITLIF NKFSHFYRRQ KQLESAMRSC DFGDGMKEVP SVNLRDYYAH
460 470
KVKSLMASLT NMSRSSPSEL SLDDSLH
Length:477
Mass (Da):54,289
Last modified:January 1, 1998 - v1
Checksum:iC7AD7AA3AE312B2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008574 mRNA Translation: AAB72051.1
AK048819 mRNA Translation: BAC33468.1
AK087481 mRNA Translation: BAC39892.1
BC059833 mRNA Translation: AAH59833.1
CCDSiCCDS27421.1
RefSeqiNP_001258633.1, NM_001271704.1
NP_851834.1, NM_181317.4
UniGeneiMm.487585
Mm.71045

Genome annotation databases

EnsembliENSMUST00000072868; ENSMUSP00000072645; ENSMUSG00000050963
ENSMUST00000228725; ENSMUSP00000153984; ENSMUSG00000050963
GeneIDi16539
KEGGimmu:16539
UCSCiuc007vly.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008574 mRNA Translation: AAB72051.1
AK048819 mRNA Translation: BAC33468.1
AK087481 mRNA Translation: BAC39892.1
BC059833 mRNA Translation: AAH59833.1
CCDSiCCDS27421.1
RefSeqiNP_001258633.1, NM_001271704.1
NP_851834.1, NM_181317.4
UniGeneiMm.487585
Mm.71045

3D structure databases

ProteinModelPortaliO35174
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072645

PTM databases

iPTMnetiO35174
PhosphoSitePlusiO35174

Proteomic databases

PaxDbiO35174
PRIDEiO35174

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072868; ENSMUSP00000072645; ENSMUSG00000050963
ENSMUST00000228725; ENSMUSP00000153984; ENSMUSG00000050963
GeneIDi16539
KEGGimmu:16539
UCSCiuc007vly.2 mouse

Organism-specific databases

CTDi3788
MGIiMGI:1197011 Kcns2

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG052230
InParanoidiO35174
KOiK04932
OMAiWDESEAN
OrthoDBiEOG091G0FP3
PhylomeDBiO35174
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

ChiTaRSiKcns2 mouse
PROiPR:O35174
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050963 Expressed in 96 organ(s), highest expression level in dorsal striatum
CleanExiMM_KCNS2
GenevisibleiO35174 MM

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNS2_MOUSE
AccessioniPrimary (citable) accession number: O35174
Secondary accession number(s): Q543P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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