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Protein

Potassium voltage-gated channel subfamily S member 1

Gene

Kcns1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:9305895).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 1
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 1
Voltage-gated potassium channel subunit Kv9.1
Gene namesi
Name:Kcns1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1197019 Kcns1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 186CytoplasmicBy similarityAdd BLAST186
Transmembranei187 – 208Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini209 – 239ExtracellularBy similarityAdd BLAST31
Transmembranei240 – 262Helical; Name=Segment S2By similarityAdd BLAST23
Topological domaini263 – 273CytoplasmicBy similarityAdd BLAST11
Transmembranei274 – 291Helical; Name=Segment S3By similarityAdd BLAST18
Topological domaini292 – 309ExtracellularBy similarityAdd BLAST18
Transmembranei310 – 330Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini331 – 345CytoplasmicBy similarityAdd BLAST15
Transmembranei346 – 367Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini368 – 379ExtracellularBy similarityAdd BLAST12
Intramembranei380 – 391Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei392 – 399By similarity8
Topological domaini400 – 406ExtracellularBy similarity7
Transmembranei407 – 435Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini436 – 497CytoplasmicBy similarityAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540821 – 497Potassium voltage-gated channel subfamily S member 1Add BLAST497

Proteomic databases

PaxDbiO35173
PRIDEiO35173

PTM databases

PhosphoSitePlusiO35173

Expressioni

Tissue specificityi

Detected in brain, but not in the other tissues tested. The highest levels of expression are in olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum (PubMed:9305895).1 Publication

Gene expression databases

BgeeiENSMUSG00000040164 Expressed in 43 organ(s), highest expression level in parotid gland
CleanExiMM_KCNS1
GenevisibleiO35173 MM

Interactioni

Subunit structurei

Heterotetramer with KCNB1 and KCNB2 (PubMed:9305895). Does not form homomultimers (PubMed:9305895).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038901

Structurei

3D structure databases

ProteinModelPortaliO35173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi392 – 397Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi219 – 228Poly-Ala10

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG052230
InParanoidiO35173
KOiK04931
OMAiDSCCSYR
OrthoDBiEOG091G0FP3
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

O35173-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSEFPGPGS RVPWRPRDEA LRVNVGGVRR LLSARALARF PGTRLGRLQA
60 70 80 90 100
AASEEQARRL CDDYDAAAHE FYFDRHPGFF LGLLHFYRTG HLHVLDELCV
110 120 130 140 150
FAFGQEADYW GLGENALATC CRARYLERRV ARPRAWDEDS DAPSSVDPCP
160 170 180 190 200
DEISDVQREL ARYGAARCGR LRRRLWLTME NPGYSLPSKL FSCVSIGVVL
210 220 230 240 250
ASIAAMCIHS LPEYQAREAA AAVAAVAAGR SAEEVRDDPV LRRLEYFCIA
260 270 280 290 300
WFSFEVSSRL LLAPSTRNFF CHPLNLIDIV SVLPFYLTLL AGAALGDQRG
310 320 330 340 350
ASGEELGDLG KVVQVFRLMR IFRVLKLARH STGLRSLGAT LKHSYREVGI
360 370 380 390 400
LLLYLAVGVS VFSGVAYTAE EENEGFHTIP ACWWWGTVSM TTVGYGDVVP
410 420 430 440 450
ETVGGKLAAS GCILGGILVV ALPITIIFNK FSHFYRRQKA LEAAVRSSGQ
460 470 480 490
REFEDLLSSV DGVSDVSLET SRDTSQEGRS TDLETQAPRE PAKSHSY
Length:497
Mass (Da):54,918
Last modified:July 27, 2011 - v2
Checksum:iF734A3D4B093BEBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti440A → G in AAB72050 (PubMed:9305895).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008573 mRNA Translation: AAB72050.1
AL591512 Genomic DNA Translation: CAM21684.1
CH466551 Genomic DNA Translation: EDL06364.1
CCDSiCCDS17022.1
RefSeqiNP_032461.2, NM_008435.2
UniGeneiMm.6217

Genome annotation databases

EnsembliENSMUST00000045196; ENSMUSP00000038901; ENSMUSG00000040164
GeneIDi16538
KEGGimmu:16538
UCSCiuc008ntv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008573 mRNA Translation: AAB72050.1
AL591512 Genomic DNA Translation: CAM21684.1
CH466551 Genomic DNA Translation: EDL06364.1
CCDSiCCDS17022.1
RefSeqiNP_032461.2, NM_008435.2
UniGeneiMm.6217

3D structure databases

ProteinModelPortaliO35173
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038901

PTM databases

PhosphoSitePlusiO35173

Proteomic databases

PaxDbiO35173
PRIDEiO35173

Protocols and materials databases

DNASUi16538
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045196; ENSMUSP00000038901; ENSMUSG00000040164
GeneIDi16538
KEGGimmu:16538
UCSCiuc008ntv.1 mouse

Organism-specific databases

CTDi3787
MGIiMGI:1197019 Kcns1

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG052230
InParanoidiO35173
KOiK04931
OMAiDSCCSYR
OrthoDBiEOG091G0FP3
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

PROiPR:O35173
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040164 Expressed in 43 organ(s), highest expression level in parotid gland
CleanExiMM_KCNS1
GenevisibleiO35173 MM

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNS1_MOUSE
AccessioniPrimary (citable) accession number: O35173
Secondary accession number(s): A2A5M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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