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Protein

Golgi SNAP receptor complex member 2

Gene

Gosr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi SNAP receptor complex member 2
Alternative name(s):
27 kDa Golgi SNARE protein
Membrin
Gene namesi
Name:Gosr2
Synonyms:Gs27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1927204 Gosr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 190CytoplasmicSequence analysisAdd BLAST190
Transmembranei191 – 211Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini212VesicularSequence analysis1

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125501 – 212Golgi SNAP receptor complex member 2Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO35166
MaxQBiO35166
PaxDbiO35166
PRIDEiO35166

PTM databases

PhosphoSitePlusiO35166

Expressioni

Gene expression databases

BgeeiENSMUSG00000020946 Expressed in 292 organ(s), highest expression level in small intestine
CleanExiMM_GOSR2
ExpressionAtlasiO35166 baseline and differential
GenevisibleiO35166 MM

Interactioni

Subunit structurei

Part of a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35166, 2 interactors
MINTiO35166
STRINGi10090.ENSMUSP00000021329

Structurei

3D structure databases

ProteinModelPortaliO35166
SMRiO35166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili60 – 92Sequence analysisAdd BLAST33

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi118 – 120IxM motif; signal for cargo packaging into COPII-coated vesiclesBy similarity3

Sequence similaritiesi

Belongs to the GOSR2 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3251 Eukaryota
ENOG4111M37 LUCA
GeneTreeiENSGT00490000043403
HOGENOMiHOG000231153
HOVERGENiHBG051765
InParanoidiO35166
KOiK08496
OMAiYHQTNKL
OrthoDBiEOG091G0KS8
PhylomeDBiO35166
TreeFamiTF313702

Family and domain databases

InterProiView protein in InterPro
IPR027027 GOSR2/Membrin/Bos1
PIRSFiPIRSF028865 Membrin-2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35166-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLYQQTNK QVQEIQSHMG RLERADKQSV HLVENEIQAS IEQIFSHLER
60 70 80 90 100
LEILSSKEPL NRRQNAKLRV DQLKYDVQHL QTALRNFQHR RQVREQQERQ
110 120 130 140 150
RDELLSRTFT TNDSDTTIPM DESLQFNSSL HNIHHGMDDL IGGGHSILEG
160 170 180 190 200
LRAQRLTLKG TQKKILDIAN MLGLSNTVMR LIEKRAFQDK YFMIGGMLLT
210
CAVMFLVVQY LT
Length:212
Mass (Da):24,725
Last modified:August 31, 2004 - v2
Checksum:i1622371B06090A6C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A9I0A2A9I0_MOUSE
Golgi SNAP receptor complex member ...
Gosr2 mCG_19158
165Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99R → I in AAB82653 (PubMed:9349823).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007550 mRNA Translation: AAB82653.1
AK005697 mRNA Translation: BAB24194.1
AK013052 mRNA Translation: BAB28622.1
AK150004 mRNA Translation: BAE29231.1
BC008525 mRNA Translation: AAH08525.1
BC051253 mRNA Translation: AAH51253.1
CCDSiCCDS25521.1
RefSeqiNP_062624.2, NM_019650.3
UniGeneiMm.195451

Genome annotation databases

EnsembliENSMUST00000021329; ENSMUSP00000021329; ENSMUSG00000020946
GeneIDi56494
KEGGimmu:56494
UCSCiuc007lvo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007550 mRNA Translation: AAB82653.1
AK005697 mRNA Translation: BAB24194.1
AK013052 mRNA Translation: BAB28622.1
AK150004 mRNA Translation: BAE29231.1
BC008525 mRNA Translation: AAH08525.1
BC051253 mRNA Translation: AAH51253.1
CCDSiCCDS25521.1
RefSeqiNP_062624.2, NM_019650.3
UniGeneiMm.195451

3D structure databases

ProteinModelPortaliO35166
SMRiO35166
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35166, 2 interactors
MINTiO35166
STRINGi10090.ENSMUSP00000021329

PTM databases

PhosphoSitePlusiO35166

Proteomic databases

EPDiO35166
MaxQBiO35166
PaxDbiO35166
PRIDEiO35166

Protocols and materials databases

DNASUi56494
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021329; ENSMUSP00000021329; ENSMUSG00000020946
GeneIDi56494
KEGGimmu:56494
UCSCiuc007lvo.2 mouse

Organism-specific databases

CTDi9570
MGIiMGI:1927204 Gosr2

Phylogenomic databases

eggNOGiKOG3251 Eukaryota
ENOG4111M37 LUCA
GeneTreeiENSGT00490000043403
HOGENOMiHOG000231153
HOVERGENiHBG051765
InParanoidiO35166
KOiK08496
OMAiYHQTNKL
OrthoDBiEOG091G0KS8
PhylomeDBiO35166
TreeFamiTF313702

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSiGosr2 mouse
PROiPR:O35166
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020946 Expressed in 292 organ(s), highest expression level in small intestine
CleanExiMM_GOSR2
ExpressionAtlasiO35166 baseline and differential
GenevisibleiO35166 MM

Family and domain databases

InterProiView protein in InterPro
IPR027027 GOSR2/Membrin/Bos1
PIRSFiPIRSF028865 Membrin-2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGOSR2_MOUSE
AccessioniPrimary (citable) accession number: O35166
Secondary accession number(s): Q3UDN0, Q9CR77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 31, 2004
Last modified: September 12, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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