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UniProtKB - O35165 (GOSR2_RAT)
Protein
Golgi SNAP receptor complex member 2
Gene
Gosr2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
1 PublicationGO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- intra-Golgi vesicle-mediated transport Source: UniProtKB
- protein transport Source: UniProtKB-KW
- vesicle fusion Source: GO_Central
- vesicle-mediated transport Source: RGD
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-204005, COPII-mediated vesicle transport R-RNO-5694530, Cargo concentration in the ER R-RNO-6807878, COPI-mediated anterograde transport R-RNO-6811438, Intra-Golgi traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Golgi SNAP receptor complex member 2Alternative name(s): 27 kDa Golgi SNARE protein Membrin |
Gene namesi | Name:Gosr2 Synonyms:Gs27 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 62079, Gosr2 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network membrane 1 Publication; Single-pass type IV membrane protein Sequence analysis
- Golgi apparatus membrane 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication
Note: Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: RGD
Endosome
- late endosome membrane Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: RGD
- Golgi membrane Source: UniProtKB
Other locations
- ER to Golgi transport vesicle membrane Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- SNARE complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 190 | CytoplasmicSequence analysisAdd BLAST | 190 | |
Transmembranei | 191 – 211 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 212 | VesicularSequence analysis | 1 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212551 | 1 – 212 | Golgi SNAP receptor complex member 2Add BLAST | 212 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | O35165 |
PaxDbi | O35165 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000003506, Expressed in adult mammalian kidney and 21 other tissues |
Genevisiblei | O35165, RN |
Interactioni
Subunit structurei
Part of a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6.
3 PublicationsGO - Molecular functioni
- SNARE binding Source: GO_Central
Protein-protein interaction databases
CORUMi | O35165 |
IntActi | O35165, 4 interactors |
STRINGi | 10116.ENSRNOP00000005046 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 61 – 107 | Sequence analysisAdd BLAST | 47 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 118 – 120 | IxM motif; signal for cargo packaging into COPII-coated vesiclesBy similarity | 3 |
Sequence similaritiesi
Belongs to the GOSR2 family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3251, Eukaryota |
GeneTreei | ENSGT00950000183192 |
HOGENOMi | CLU_083740_0_1_1 |
InParanoidi | O35165 |
OMAi | RMRVDQL |
OrthoDBi | 1139640at2759 |
PhylomeDBi | O35165 |
TreeFami | TF313702 |
Family and domain databases
Gene3Di | 1.20.58.400, 1 hit |
InterProi | View protein in InterPro IPR027027, GOSR2/Membrin/Bos1 IPR038407, v-SNARE_N_sf |
PIRSFi | PIRSF028865, Membrin-2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O35165-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPLYQQTHK QVHEIQSHMG RLETADKQSV HLVENEIQAS IDQIFSHLER
60 70 80 90 100
LEILSSKEPP NRRQNAKLRV DQLKYDVQHL QTALRNFQHR RQAKEQQERQ
110 120 130 140 150
RDELLSRTFT TNDSDTTIPM DESLQFNSSL QNIHHGMDDL IGGGHSILEG
160 170 180 190 200
LRAQRLTLKG TQKKILDIAN MLGLSNTVMR LIEKRAFQDK YFMIGGMLLT
210
CAVMFLVVQY LT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A8I6AG32 | A0A8I6AG32_RAT | Golgi SNAP receptor complex member ... | Gosr2 rCG_34278 | 165 | Annotation score: | ||
A0A8I6G6F5 | A0A8I6G6F5_RAT | Golgi SNAP receptor complex member ... | Gosr2 | 203 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | S → Y in AAB82652 (PubMed:9349823).Curated | 1 | |
Sequence conflicti | 187 – 188 | FQ → LE in AAB82652 (PubMed:9349823).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007549 mRNA Translation: AAB82652.1 U91539 mRNA Translation: AAC53131.1 BC061994 mRNA Translation: AAH61994.1 |
RefSeqi | NP_113873.1, NM_031685.2 |
Genome annotation databases
Ensembli | ENSRNOT00000114651; ENSRNOP00000084049; ENSRNOG00000003506 |
GeneIDi | 64154 |
KEGGi | rno:64154 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007549 mRNA Translation: AAB82652.1 U91539 mRNA Translation: AAC53131.1 BC061994 mRNA Translation: AAH61994.1 |
RefSeqi | NP_113873.1, NM_031685.2 |
3D structure databases
AlphaFoldDBi | O35165 |
SMRi | O35165 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | O35165 |
IntActi | O35165, 4 interactors |
STRINGi | 10116.ENSRNOP00000005046 |
Proteomic databases
jPOSTi | O35165 |
PaxDbi | O35165 |
Genome annotation databases
Ensembli | ENSRNOT00000114651; ENSRNOP00000084049; ENSRNOG00000003506 |
GeneIDi | 64154 |
KEGGi | rno:64154 |
Organism-specific databases
CTDi | 9570 |
RGDi | 62079, Gosr2 |
Phylogenomic databases
eggNOGi | KOG3251, Eukaryota |
GeneTreei | ENSGT00950000183192 |
HOGENOMi | CLU_083740_0_1_1 |
InParanoidi | O35165 |
OMAi | RMRVDQL |
OrthoDBi | 1139640at2759 |
PhylomeDBi | O35165 |
TreeFami | TF313702 |
Enzyme and pathway databases
Reactomei | R-RNO-204005, COPII-mediated vesicle transport R-RNO-5694530, Cargo concentration in the ER R-RNO-6807878, COPI-mediated anterograde transport R-RNO-6811438, Intra-Golgi traffic |
Miscellaneous databases
PROi | PR:O35165 |
Gene expression databases
Bgeei | ENSRNOG00000003506, Expressed in adult mammalian kidney and 21 other tissues |
Genevisiblei | O35165, RN |
Family and domain databases
Gene3Di | 1.20.58.400, 1 hit |
InterProi | View protein in InterPro IPR027027, GOSR2/Membrin/Bos1 IPR038407, v-SNARE_N_sf |
PIRSFi | PIRSF028865, Membrin-2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GOSR2_RAT | |
Accessioni | O35165Primary (citable) accession number: O35165 Secondary accession number(s): O08566, Q6GSW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 2007 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families