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UniProtKB - O35161 (CELR1_MOUSE)

Protein

Cadherin EGF LAG seven-pass G-type receptor 1

Gene

Celsr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB
  • protein dimerization activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Celsr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1100883 Celsr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 2484ExtracellularSequence analysisAdd BLAST2455
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2485 – 2505Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2506 – 2516CytoplasmicSequence analysisAdd BLAST11
Transmembranei2517 – 2537Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2538 – 2542ExtracellularSequence analysis5
Transmembranei2543 – 2563Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2564 – 2587CytoplasmicSequence analysisAdd BLAST24
Transmembranei2588 – 2608Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2609 – 2625ExtracellularSequence analysisAdd BLAST17
Transmembranei2626 – 2646Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2647 – 2670CytoplasmicSequence analysisAdd BLAST24
Transmembranei2671 – 2691Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2692 – 2694ExtracellularSequence analysis3
Transmembranei2695 – 2715Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2716 – 3034CytoplasmicSequence analysisAdd BLAST319

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291530 – 3034Cadherin EGF LAG seven-pass G-type receptor 1Add BLAST3005

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi561N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi649N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi793N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1302N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1322 ↔ 1333By similarity
Disulfide bondi1327 ↔ 1364By similarity
Disulfide bondi1366 ↔ 1375By similarity
Disulfide bondi1382 ↔ 1393By similarity
Disulfide bondi1387 ↔ 1402By similarity
Disulfide bondi1404 ↔ 1413By similarity
Disulfide bondi1422 ↔ 1433By similarity
Disulfide bondi1427 ↔ 1443By similarity
Disulfide bondi1445 ↔ 1455By similarity
Glycosylationi1591N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1635 ↔ 1661By similarity
Glycosylationi1638N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1655N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1668 ↔ 1679By similarity
Disulfide bondi1673 ↔ 1688By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1681(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi1690 ↔ 1699By similarity
Disulfide bondi1855 ↔ 1885By similarity
Disulfide bondi1891 ↔ 1902By similarity
Disulfide bondi1896 ↔ 1911By similarity
Modified residuei1904(3R)-3-hydroxyaspartateSequence analysis1
Disulfide bondi1913 ↔ 1922By similarity
Disulfide bondi1926 ↔ 1937By similarity
Disulfide bondi1931 ↔ 1949By similarity
Disulfide bondi1951 ↔ 1960By similarity
Disulfide bondi1968 ↔ 1981By similarity
Disulfide bondi1983 ↔ 1993By similarity
Glycosylationi1994N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2000 ↔ 2015By similarity
Disulfide bondi2002 ↔ 2018By similarity
Disulfide bondi2020 ↔ 2030By similarity
Disulfide bondi2039 ↔ 2048By similarity
Disulfide bondi2051 ↔ 2063By similarity
Glycosylationi2118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2452N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2538N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2776PhosphoserineCombined sources1
Modified residuei2779PhosphoserineBy similarity1
Modified residuei2886PhosphoserineCombined sources1
Modified residuei2888PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		O35161

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O35161

PeptideAtlas

More...PeptideAtlasi		O35161

PRoteomics IDEntifications database

More...PRIDEi		O35161

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O35161

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O35161

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain, where it is localized principally in the ependymal cell layer, choroid plexus and the area postrema. Also found in spinal chord and in the eye.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected at E6. Predominantly expressed in the developing CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. During gastrulation, it is expressed in the vicinity of the primitive streak, and becomes predominant in that area at late gastrulation. At E10, detected in ventricular zones (VZ), but not in marginal zones (MZ), and weakly in other structures. Between E12 and E15, a high expression is present in the VZ in all brain areas. No expression in differentiated neuronal fields. In the newborn and postnatal stages, expression remains restricted to the VZ. Also found weakly in fetal lungs, kidney and epithelia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000016028 Expressed in 218 organ(s), highest expression level in molar tooth

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O35161 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
atp6ap2Q7T0S32EBI-8294650,EBI-8294706From Xenopus laevis.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		O35161, 1 interactor

Molecular INTeraction database

More...MINTi		O35161

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000016172

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O35161

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O35161

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini261 – 368Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini369 – 474Cadherin 2PROSITE-ProRule annotationAdd BLAST106
Domaini475 – 580Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini581 – 702Cadherin 4PROSITE-ProRule annotationAdd BLAST122
Domaini703 – 804Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini805 – 907Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini908 – 1014Cadherin 7PROSITE-ProRule annotationAdd BLAST107
Domaini1015 – 1116Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1121 – 1239Cadherin 9PROSITE-ProRule annotationAdd BLAST119
Domaini1318 – 1376EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1378 – 1414EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1418 – 1456EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1457 – 1661Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1664 – 1700EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1704 – 1885Laminin G-like 2PROSITE-ProRule annotationAdd BLAST182
Domaini1887 – 1922EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini1923 – 1961EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1962 – 1994EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST33
Domaini1996 – 2031EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2018 – 2065Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2423 – 2475GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2674 – 2678Poly-Leu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Curated

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4289 Eukaryota
ENOG410XTGH LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159839

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231346

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG050887

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O35161

KEGG Orthology (KO)

More...KOi		K04600

Identification of Orthologs from Complete Genome Data

More...OMAi		YVVGWGI

Database of Orthologous Groups

More...OrthoDBi		23882at2759

TreeFam database of animal gene trees

More...TreeFami		TF323983

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35161-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSSPRVLP ALVLLAAAAL PALELGAAAW ELRVPGGARA FALGPGWSYR 
        60         70         80         90        100
LDTTRTPREL LDVSREGPAA GRRLGLGAGT LGCARLAGRL LPLQVRLVAR 
       110        120        130        140        150
GAPTAPSLVL RARAYGARCG VRLLRRSARG AELRSPAVRS VPGLGDALCF 
       160        170        180        190        200
PAAGGGAASL TSVLEAITNF PACSCPPVAG TGCRRGPICL RPGGSAELRL 
       210        220        230        240        250
VCALGRAAGA VWVELVIEAT SGTPSESPSV SPSLLNLSQP RAGVVRRSRR 
       260        270        280        290        300
GTGSSTSPQF PLPSYQVSVP ENEPAGTAVI ELRAHDPDEG DAGRLSYQME 
       310        320        330        340        350
ALFDERSNGY FLIDAATGAV TTARSLDRET KDTHVLKVSA VDHGSPRRSA 
       360        370        380        390        400
ATYLTVTVSD TNDHSPVFEQ SEYRERIREN LEVGYEVLTI RATDGDAPSN 
       410        420        430        440        450
ANMRYRLLEG AGGVFEIDAR SGVVRTRAVV DREEAAEYQL LVEANDQGRN 
       460        470        480        490        500
PGPLSASATV HIVVEDENDN YPQFSEKRYV VQVPEDVAVN TAVLRVQATD 
       510        520        530        540        550
RDQGQNAAIH YSIVSGNLKG QFYLHSLSGS LDVINPLDFE AIREYTLRIK 
       560        570        580        590        600
AQDGGRPPLI NSSGLVSVQV LDVNDNAPIF VSSPFQAAVL ENVPLGHSVL 
       610        620        630        640        650
HIQAVDADAG ENARLQYRLV DTASTIVGGS SVDSENPASA PDFPFQIHNS 
       660        670        680        690        700
SGWITVCAEL DREEVEHYSF GVEAVDHGSP AMSSSASVSI TVLDVNDNDP 
       710        720        730        740        750
MFTQPVYELR LNEDAAVGSS VLTLRARDRD ANSVITYQLT GGNTRNRFAL 
       760        770        780        790        800
SSQSGGGLIT LALPLDYKQE RQYVLAVTAS DGTRSHTAQV FINVTDANTH 
       810        820        830        840        850
RPVFQSSHYT VSVSEDRPVG TSIATISATD EDTGENARIT YVLEDPVPQF 
       860        870        880        890        900
RIDPDTGTIY TMTELDYEDQ AAYTLAITAQ DNGIPQKSDT TSLEILILDA 
       910        920        930        940        950
NDNAPRFLRD FYQGSVFEDA PPSTSVLQVS ATDRDSGPNG RLLYTFQGGD 
       960        970        980        990       1000
DGDGDFYIEP TSGVIRTQRR LDRENVAVYN LWALAVDRGS PNPLSASVGI 
      1010       1020       1030       1040       1050
QVSVLDINDN PPVFEKDELE LFVEENSPVG SVVARIRAND PDEGPNAQIM 
      1060       1070       1080       1090       1100
YQIVEGNVPE VFQLDLLSGD LRALVELDFE VRRDYMLVVQ ATSAPLVSRA 
      1110       1120       1130       1140       1150
TVHIRLLDQN DNPPELPDFQ ILFNNYVTNK SNSFPSGVIG RIPAHDPDLS 
      1160       1170       1180       1190       1200
DSLNYTFLQG NELSLLLLDP ATGELQLSRD LDNNRPLEAL MEVSVSDGIH 
      1210       1220       1230       1240       1250
SVTALCTLRV TIITDDMLTN SITVRLENMS QEKFLSPLLS LFVEGVATVL 
      1260       1270       1280       1290       1300
STTKDDIFVF NIQNDTDVSS NILNVTFSAL LPGGTRGRFF PSEDLQEQIY 
      1310       1320       1330       1340       1350
LNRTLLTTIS AQRVLPFDDN ICLREPCENY MKCVSVLRFD SSAPFISSTT 
      1360       1370       1380       1390       1400
VLFRPIHPIT GLRCRCPPGF TGDYCETEID LCYSNPCGAN GRCRSREGGY 
      1410       1420       1430       1440       1450
TCECFEDFTG EHCQVNVRSG RCASGVCKNG GTCVNLLIGG FHCVCPPGEY 
      1460       1470       1480       1490       1500
EHPYCEVSTR SFPPQSFVTF RGLRQRFHFT VSLAFATQDR NALLLYNGRF 
      1510       1520       1530       1540       1550
NEKHDFIALE IVEEQLQLTF SAGETTTTVT PQVPGGVSDG RWHSVLVQYY 
      1560       1570       1580       1590       1600
NKPNIGHLGL PHGPSGEKVA VVTVDDCDAA VAVHFGSYVG NYSCAAQGTQ 
      1610       1620       1630       1640       1650
SGSKKSLDLT GPLLLGGVPN LPEDFPVHSR QFVGCMRNLS IDGRIVDMAA 
      1660       1670       1680       1690       1700
FIANNGTRAG CASQRNFCDG TSCQNGGTCV NRWNTYLCEC PLRFGGKNCE 
      1710       1720       1730       1740       1750
QAMPHPQRFT GESVVLWSDL DITISVPWYL GLMFRTRKED GVLMEATAGT 
      1760       1770       1780       1790       1800
SSRLHLQILN SYIRFEVSYG PSDVASMQLS KSRITDGGWH HLLIELRSAK 
      1810       1820       1830       1840       1850
EGKDIKYLAV MTLDYGMDQS TVQIGNQLPG LKMRTIVIGG VTEDKVSVRH 
      1860       1870       1880       1890       1900
GFRGCMQGVR MGETSTNIAT LNMNDALKVR VKDGCDVEDP CASSPCPPHS 
      1910       1920       1930       1940       1950
HCRDTWDSYS CICDRGYFGK KCVDACLLNP CKHVAACVRS PNTPRGYSCE 
      1960       1970       1980       1990       2000
CGPGHYGQYC ENKVDLPCPK GWWGNPVCGP CHCAVSQGFD PDCNKTNGQC 
      2010       2020       2030       2040       2050
QCKENYYKPP AQDACLPCDC FPHGSHSRAC DMDTGQCACK PGVIGRQCNR 
      2060       2070       2080       2090       2100
CDNPFAEVTS LGCEVIYNGC PRAFEAGIWW PQTKFGQPAA VPCPKGSVGN 
      2110       2120       2130       2140       2150
AVRHCSGEKG WLPPELFNCT SGSFVDLKAL NEKLNRNETR MDGNRSLRLA 
      2160       2170       2180       2190       2200
KALRNATQGN STLFGNDVRT AYQLLARILQ HESRQQGFDL AATREANFHE 
      2210       2220       2230       2240       2250
DVVHTGSALL APATEASWEQ IQRSEAGAAQ LLRHFEAYFS NVARNVKRTY 
      2260       2270       2280       2290       2300
LRPFVIVTAN MILAVDIFDK LNFTGAQVPR FEDIQEELPR ELESSVSFPA 
      2310       2320       2330       2340       2350
DTFKPPEKKE GPVVRLTNRR TTPLTAQPEP RAERETSSSR RRRHPDEPGQ 
      2360       2370       2380       2390       2400
FAVALVVIYR TLGQLLPEHY DPDHRSLRLP NRPVINTPVV SAMVYSEGTP 
      2410       2420       2430       2440       2450
LPSSLQRPIL VEFSLLETEE RSKPVCVFWN HSLDTGGTGG WSAKGCELLS 
      2460       2470       2480       2490       2500
RNRTHVTCQC SHSASCAVLM DISRREHGEV LPLKIITYAA LSLSLVALLV 
      2510       2520       2530       2540       2550
AFVLLSLVRT LRSNLHSIHK NLITALFFSQ LIFMVGINQT ENPFLCTVVA 
      2560       2570       2580       2590       2600
ILLHYVSMGT FAWTLVENLH VYRMLTEVRN IDTGPMRFYH VVGWGIPAIV 
      2610       2620       2630       2640       2650
TGLAVGLDPQ GYGNPDFCWL SLQDTLIWSF AGPVGTVIII NTVIFVLSAK 
      2660       2670       2680       2690       2700
VSCQRKHHYY ERKGVVSMLR TAFLLLLLVT ATWLLGLLAV NSDTLSFHYL 
      2710       2720       2730       2740       2750
FAAFSCLQGI FVLLFHCVAH REVRKHLRAV LAGKKLQLDD SATTRATLLT 
      2760       2770       2780       2790       2800
RSLNCNNTYS EGPDMLRTAL GESTASLDST TRDEGVQKLS VSSGPARGNH 
      2810       2820       2830       2840       2850
GEPDASFIPR NSKKAHGPDS DSDSELSLDE HSSSYASSHT SDSEDDGGEA 
      2860       2870       2880       2890       2900
EDKWNPAGGP AHSTPKADAL ANHVPAGWPD ESLAGSDSEE LDTEPHLKVE 
      2910       2920       2930       2940       2950
TKVSVELHRQ AQGNHCGDRP SDPESGVLAK PVAVLSSQPQ EQRKGILKNK 
      2960       2970       2980       2990       3000
VTYPPPLPEQ PLKSRLREKL ADCEQSPTSS RTSSLGSGDG VHATDCVITI 
      3010       3020       3030 
KTPRREPGRE HLNGVAMNVR TGSAQANGSD SEKP
Length:3,034
Mass (Da):330,471
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD9C4812AA1F0BCD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BPU9A0A2I3BPU9_MOUSE
Cadherin EGF LAG seven-pass G-type ...
Celsr1
1,672Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQH0A0A2I3BQH0_MOUSE
Cadherin EGF LAG seven-pass G-type ...
Celsr1
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti218E → Q in AAC68836 (PubMed:9858697).Curated1
Sequence conflicti1050M → I in AAC68836 (PubMed:9858697).Curated1
Sequence conflicti1900 – 1901SH → RP in AAC68836 (PubMed:9858697).Curated2
Sequence conflicti2524T → A in AAC68836 (PubMed:9858697).Curated1
Sequence conflicti2805A → T in AAC68836 (PubMed:9858697).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF031572 mRNA Translation: AAC68836.1
AC116764 Genomic DNA No translation available.
AC139513 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS37172.1

Protein sequence database of the Protein Information Resource

More...PIRi		T14119

NCBI Reference Sequences

More...RefSeqi		NP_034016.2, NM_009886.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.22680

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000016172; ENSMUSP00000016172; ENSMUSG00000016028

Database of genes from NCBI RefSeq genomes

More...GeneIDi		12614

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:12614

UCSC genome browser

More...UCSCi		uc007xdt.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031572 mRNA Translation: AAC68836.1
AC116764 Genomic DNA No translation available.
AC139513 Genomic DNA No translation available.
CCDSiCCDS37172.1
PIRiT14119
RefSeqiNP_034016.2, NM_009886.2
UniGeneiMm.22680

3D structure databases

ProteinModelPortaliO35161
SMRiO35161
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35161, 1 interactor
MINTiO35161
STRINGi10090.ENSMUSP00000016172

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiO35161
PhosphoSitePlusiO35161

Proteomic databases

MaxQBiO35161
PaxDbiO35161
PeptideAtlasiO35161
PRIDEiO35161

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016172; ENSMUSP00000016172; ENSMUSG00000016028
GeneIDi12614
KEGGimmu:12614
UCSCiuc007xdt.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9620
MGIiMGI:1100883 Celsr1

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
GeneTreeiENSGT00940000159839
HOGENOMiHOG000231346
HOVERGENiHBG050887
InParanoidiO35161
KOiK04600
OMAiYVVGWGI
OrthoDBi23882at2759
TreeFamiTF323983

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Celsr1 mouse

Protein Ontology

More...PROi		PR:O35161

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000016028 Expressed in 218 organ(s), highest expression level in molar tooth
GenevisibleiO35161 MM

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 9 hits
PS00022 EGF_1, 6 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O35161
Secondary accession number(s): E9QK27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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