Cadherin EGF LAG seven-pass G-type receptor 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium ion binding Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 12842012
• G protein-coupled receptor activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 9339365
• protein dimerization activity Source: UniProtKBNon-traceable author statementⁱ
  • 9339365
• transmembrane signaling receptor activity Source: UniProtKBNon-traceable author statementⁱ
  • 9339365

GO - Biological processⁱ

• anterior/posterior pattern specification Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18849982
  • 19357712
• apical protein localization Source: MGIInferred from mutant phenotypeⁱ
  • 16687519
• cell-cell signaling Source: UniProtKBNon-traceable author statementⁱ
  • 9339365
• central nervous system development Source: UniProtKBNon-traceable author statementⁱ
  • 9339365
• establishment of body hair planar orientation Source: MGIInferred from mutant phenotypeⁱ
  • 18849982
  • 19357712
• establishment of planar polarity Source: UniProtKBInferred from mutant phenotypeⁱ
  • 12842012
• establishment of planar polarity of embryonic epithelium Source: MGIInferred from mutant phenotypeⁱ
  • 12842012
• gastrulation with mouth forming second Source: UniProtKBNon-traceable author statementⁱ
  • 9339365
• G protein-coupled receptor signaling pathway Source: UniProtKBNon-traceable author statementⁱ
  • 9339365
• hair follicle development Source: MGIInferred from mutant phenotypeⁱ
  • 18849982
• homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
• inner ear morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 12842012
• lateral sprouting involved in lung morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 20223754
• locomotory behavior Source: MGIInferred from mutant phenotypeⁱ
  • 10932191
• neural tube closure Source: UniProtKBInferred from mutant phenotypeⁱ
  • 12842012
• neuron migration Source: MGIInferred from mutant phenotypeⁱ
  • 20631168
• orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 20223754
• planar cell polarity pathway involved in neural tube closure Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 20704721
• planar dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 20223754
• protein localization involved in establishment of planar polarity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18849982
• regulation of actin cytoskeleton organization Source: MGIInferred from mutant phenotypeⁱ
  • 20223754
• regulation of neurotransmitter secretion Source: UniProtKBNon-traceable author statementⁱ
  • 9339365
• Rho protein signal transduction Source: MGIInferred from mutant phenotypeⁱ
  • 20223754
• signal transduction Source: UniProtKBNon-traceable author statementⁱ
  • 9339365
• wound healing Source: MGIInferred from genetic interactionⁱ
  • 20643356

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein dimerization activity Source: UniProtKBNon-traceable author statementⁱ
  • 9339365

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAPSSPRVLP ALVLLAAAAL PALELGAAAW ELRVPGGARA FALGPGWSYR 
        60         70         80         90        100
LDTTRTPREL LDVSREGPAA GRRLGLGAGT LGCARLAGRL LPLQVRLVAR 
       110        120        130        140        150
GAPTAPSLVL RARAYGARCG VRLLRRSARG AELRSPAVRS VPGLGDALCF 
       160        170        180        190        200
PAAGGGAASL TSVLEAITNF PACSCPPVAG TGCRRGPICL RPGGSAELRL 
       210        220        230        240        250
VCALGRAAGA VWVELVIEAT SGTPSESPSV SPSLLNLSQP RAGVVRRSRR 
       260        270        280        290        300
GTGSSTSPQF PLPSYQVSVP ENEPAGTAVI ELRAHDPDEG DAGRLSYQME 
       310        320        330        340        350
ALFDERSNGY FLIDAATGAV TTARSLDRET KDTHVLKVSA VDHGSPRRSA 
       360        370        380        390        400
ATYLTVTVSD TNDHSPVFEQ SEYRERIREN LEVGYEVLTI RATDGDAPSN 
       410        420        430        440        450
ANMRYRLLEG AGGVFEIDAR SGVVRTRAVV DREEAAEYQL LVEANDQGRN 
       460        470        480        490        500
PGPLSASATV HIVVEDENDN YPQFSEKRYV VQVPEDVAVN TAVLRVQATD 
       510        520        530        540        550
RDQGQNAAIH YSIVSGNLKG QFYLHSLSGS LDVINPLDFE AIREYTLRIK 
       560        570        580        590        600
AQDGGRPPLI NSSGLVSVQV LDVNDNAPIF VSSPFQAAVL ENVPLGHSVL 
       610        620        630        640        650
HIQAVDADAG ENARLQYRLV DTASTIVGGS SVDSENPASA PDFPFQIHNS 
       660        670        680        690        700
SGWITVCAEL DREEVEHYSF GVEAVDHGSP AMSSSASVSI TVLDVNDNDP 
       710        720        730        740        750
MFTQPVYELR LNEDAAVGSS VLTLRARDRD ANSVITYQLT GGNTRNRFAL 
       760        770        780        790        800
SSQSGGGLIT LALPLDYKQE RQYVLAVTAS DGTRSHTAQV FINVTDANTH 
       810        820        830        840        850
RPVFQSSHYT VSVSEDRPVG TSIATISATD EDTGENARIT YVLEDPVPQF 
       860        870        880        890        900
RIDPDTGTIY TMTELDYEDQ AAYTLAITAQ DNGIPQKSDT TSLEILILDA 
       910        920        930        940        950
NDNAPRFLRD FYQGSVFEDA PPSTSVLQVS ATDRDSGPNG RLLYTFQGGD 
       960        970        980        990       1000
DGDGDFYIEP TSGVIRTQRR LDRENVAVYN LWALAVDRGS PNPLSASVGI 
      1010       1020       1030       1040       1050
QVSVLDINDN PPVFEKDELE LFVEENSPVG SVVARIRAND PDEGPNAQIM 
      1060       1070       1080       1090       1100
YQIVEGNVPE VFQLDLLSGD LRALVELDFE VRRDYMLVVQ ATSAPLVSRA 
      1110       1120       1130       1140       1150
TVHIRLLDQN DNPPELPDFQ ILFNNYVTNK SNSFPSGVIG RIPAHDPDLS 
      1160       1170       1180       1190       1200
DSLNYTFLQG NELSLLLLDP ATGELQLSRD LDNNRPLEAL MEVSVSDGIH 
      1210       1220       1230       1240       1250
SVTALCTLRV TIITDDMLTN SITVRLENMS QEKFLSPLLS LFVEGVATVL 
      1260       1270       1280       1290       1300
STTKDDIFVF NIQNDTDVSS NILNVTFSAL LPGGTRGRFF PSEDLQEQIY 
      1310       1320       1330       1340       1350
LNRTLLTTIS AQRVLPFDDN ICLREPCENY MKCVSVLRFD SSAPFISSTT 
      1360       1370       1380       1390       1400
VLFRPIHPIT GLRCRCPPGF TGDYCETEID LCYSNPCGAN GRCRSREGGY 
      1410       1420       1430       1440       1450
TCECFEDFTG EHCQVNVRSG RCASGVCKNG GTCVNLLIGG FHCVCPPGEY 
      1460       1470       1480       1490       1500
EHPYCEVSTR SFPPQSFVTF RGLRQRFHFT VSLAFATQDR NALLLYNGRF 
      1510       1520       1530       1540       1550
NEKHDFIALE IVEEQLQLTF SAGETTTTVT PQVPGGVSDG RWHSVLVQYY 
      1560       1570       1580       1590       1600
NKPNIGHLGL PHGPSGEKVA VVTVDDCDAA VAVHFGSYVG NYSCAAQGTQ 
      1610       1620       1630       1640       1650
SGSKKSLDLT GPLLLGGVPN LPEDFPVHSR QFVGCMRNLS IDGRIVDMAA 
      1660       1670       1680       1690       1700
FIANNGTRAG CASQRNFCDG TSCQNGGTCV NRWNTYLCEC PLRFGGKNCE 
      1710       1720       1730       1740       1750
QAMPHPQRFT GESVVLWSDL DITISVPWYL GLMFRTRKED GVLMEATAGT 
      1760       1770       1780       1790       1800
SSRLHLQILN SYIRFEVSYG PSDVASMQLS KSRITDGGWH HLLIELRSAK 
      1810       1820       1830       1840       1850
EGKDIKYLAV MTLDYGMDQS TVQIGNQLPG LKMRTIVIGG VTEDKVSVRH 
      1860       1870       1880       1890       1900
GFRGCMQGVR MGETSTNIAT LNMNDALKVR VKDGCDVEDP CASSPCPPHS 
      1910       1920       1930       1940       1950
HCRDTWDSYS CICDRGYFGK KCVDACLLNP CKHVAACVRS PNTPRGYSCE 
      1960       1970       1980       1990       2000
CGPGHYGQYC ENKVDLPCPK GWWGNPVCGP CHCAVSQGFD PDCNKTNGQC 
      2010       2020       2030       2040       2050
QCKENYYKPP AQDACLPCDC FPHGSHSRAC DMDTGQCACK PGVIGRQCNR 
      2060       2070       2080       2090       2100
CDNPFAEVTS LGCEVIYNGC PRAFEAGIWW PQTKFGQPAA VPCPKGSVGN 
      2110       2120       2130       2140       2150
AVRHCSGEKG WLPPELFNCT SGSFVDLKAL NEKLNRNETR MDGNRSLRLA 
      2160       2170       2180       2190       2200
KALRNATQGN STLFGNDVRT AYQLLARILQ HESRQQGFDL AATREANFHE 
      2210       2220       2230       2240       2250
DVVHTGSALL APATEASWEQ IQRSEAGAAQ LLRHFEAYFS NVARNVKRTY 
      2260       2270       2280       2290       2300
LRPFVIVTAN MILAVDIFDK LNFTGAQVPR FEDIQEELPR ELESSVSFPA 
      2310       2320       2330       2340       2350
DTFKPPEKKE GPVVRLTNRR TTPLTAQPEP RAERETSSSR RRRHPDEPGQ 
      2360       2370       2380       2390       2400
FAVALVVIYR TLGQLLPEHY DPDHRSLRLP NRPVINTPVV SAMVYSEGTP 
      2410       2420       2430       2440       2450
LPSSLQRPIL VEFSLLETEE RSKPVCVFWN HSLDTGGTGG WSAKGCELLS 
      2460       2470       2480       2490       2500
RNRTHVTCQC SHSASCAVLM DISRREHGEV LPLKIITYAA LSLSLVALLV 
      2510       2520       2530       2540       2550
AFVLLSLVRT LRSNLHSIHK NLITALFFSQ LIFMVGINQT ENPFLCTVVA 
      2560       2570       2580       2590       2600
ILLHYVSMGT FAWTLVENLH VYRMLTEVRN IDTGPMRFYH VVGWGIPAIV 
      2610       2620       2630       2640       2650
TGLAVGLDPQ GYGNPDFCWL SLQDTLIWSF AGPVGTVIII NTVIFVLSAK 
      2660       2670       2680       2690       2700
VSCQRKHHYY ERKGVVSMLR TAFLLLLLVT ATWLLGLLAV NSDTLSFHYL 
      2710       2720       2730       2740       2750
FAAFSCLQGI FVLLFHCVAH REVRKHLRAV LAGKKLQLDD SATTRATLLT 
      2760       2770       2780       2790       2800
RSLNCNNTYS EGPDMLRTAL GESTASLDST TRDEGVQKLS VSSGPARGNH 
      2810       2820       2830       2840       2850
GEPDASFIPR NSKKAHGPDS DSDSELSLDE HSSSYASSHT SDSEDDGGEA 
      2860       2870       2880       2890       2900
EDKWNPAGGP AHSTPKADAL ANHVPAGWPD ESLAGSDSEE LDTEPHLKVE 
      2910       2920       2930       2940       2950
TKVSVELHRQ AQGNHCGDRP SDPESGVLAK PVAVLSSQPQ EQRKGILKNK 
      2960       2970       2980       2990       3000
VTYPPPLPEQ PLKSRLREKL ADCEQSPTSS RTSSLGSGDG VHATDCVITI 
      3010       3020       3030 
KTPRREPGRE HLNGVAMNVR TGSAQANGSD SEKP                  

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries