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UniProtKB - O35161 (CELR1_MOUSE)
Protein
Cadherin EGF LAG seven-pass G-type receptor 1
Gene
Celsr1
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor that may have an important role in cell/cell signaling during nervous system formation.
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- anterior/posterior pattern specification Source: MGI
- apical protein localization Source: MGI
- cell-cell adhesion Source: GO_Central
- establishment of body hair planar orientation Source: MGI
- establishment of planar polarity Source: UniProtKB
- establishment of planar polarity of embryonic epithelium Source: MGI
- hair follicle development Source: MGI
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- inner ear morphogenesis Source: MGI
- lateral sprouting involved in lung morphogenesis Source: MGI
- locomotory behavior Source: MGI
- neural tube closure Source: UniProtKB
- neuron migration Source: MGI
- orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: MGI
- planar cell polarity pathway involved in neural tube closure Source: MGI
- planar dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: MGI
- protein localization involved in establishment of planar polarity Source: MGI
- regulation of actin cytoskeleton organization Source: MGI
- Rho protein signal transduction Source: MGI
- wound healing Source: MGI
Keywordsi
Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin EGF LAG seven-pass G-type receptor 1 |
Gene namesi | Name:Celsr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1100883, Celsr1 |
VEuPathDBi | HostDB:ENSMUSG00000016028 |
Subcellular locationi
Plasma membrane
Nucleus
- nucleoplasm Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 2484 | ExtracellularSequence analysisAdd BLAST | 2455 | |
Transmembranei | 2485 – 2505 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2506 – 2516 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 2517 – 2537 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2538 – 2542 | ExtracellularSequence analysis | 5 | |
Transmembranei | 2543 – 2563 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2564 – 2587 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 2588 – 2608 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2609 – 2625 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 2626 – 2646 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2647 – 2670 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 2671 – 2691 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2692 – 2694 | ExtracellularSequence analysis | 3 | |
Transmembranei | 2695 – 2715 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2716 – 3034 | CytoplasmicSequence analysisAdd BLAST | 319 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000012915 | 30 – 3034 | Cadherin EGF LAG seven-pass G-type receptor 1Add BLAST | 3005 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 236 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 561 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 649 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 793 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1129 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1228 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1264 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1274 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1302 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1322 ↔ 1333 | By similarity | ||
Disulfide bondi | 1327 ↔ 1364 | By similarity | ||
Disulfide bondi | 1366 ↔ 1375 | By similarity | ||
Disulfide bondi | 1382 ↔ 1393 | By similarity | ||
Disulfide bondi | 1387 ↔ 1402 | By similarity | ||
Disulfide bondi | 1404 ↔ 1413 | By similarity | ||
Disulfide bondi | 1422 ↔ 1433 | By similarity | ||
Disulfide bondi | 1427 ↔ 1443 | By similarity | ||
Disulfide bondi | 1445 ↔ 1455 | By similarity | ||
Glycosylationi | 1591 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1635 ↔ 1661 | By similarity | ||
Glycosylationi | 1638 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1655 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1668 ↔ 1679 | By similarity | ||
Disulfide bondi | 1673 ↔ 1688 | By similarity | ||
Modified residuei | 1681 | (3R)-3-hydroxyasparagineSequence analysis | 1 | |
Disulfide bondi | 1690 ↔ 1699 | By similarity | ||
Disulfide bondi | 1855 ↔ 1885 | By similarity | ||
Disulfide bondi | 1891 ↔ 1902 | By similarity | ||
Disulfide bondi | 1896 ↔ 1911 | By similarity | ||
Modified residuei | 1904 | (3R)-3-hydroxyaspartateSequence analysis | 1 | |
Disulfide bondi | 1913 ↔ 1922 | By similarity | ||
Disulfide bondi | 1926 ↔ 1937 | By similarity | ||
Disulfide bondi | 1931 ↔ 1949 | By similarity | ||
Disulfide bondi | 1951 ↔ 1960 | By similarity | ||
Disulfide bondi | 1968 ↔ 1981 | By similarity | ||
Disulfide bondi | 1983 ↔ 1993 | By similarity | ||
Glycosylationi | 1994 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 2000 ↔ 2015 | By similarity | ||
Disulfide bondi | 2002 ↔ 2018 | By similarity | ||
Disulfide bondi | 2020 ↔ 2030 | By similarity | ||
Disulfide bondi | 2039 ↔ 2048 | By similarity | ||
Disulfide bondi | 2051 ↔ 2063 | By similarity | ||
Glycosylationi | 2118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2144 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2155 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2160 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2272 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2430 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2452 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2538 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 2776 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2779 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2886 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2888 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, Hydroxylation, PhosphoproteinProteomic databases
EPDi | O35161 |
MaxQBi | O35161 |
PaxDbi | O35161 |
PeptideAtlasi | O35161 |
PRIDEi | O35161 |
ProteomicsDBi | 281530 |
PTM databases
GlyGeni | O35161, 23 sites |
iPTMneti | O35161 |
PhosphoSitePlusi | O35161 |
Expressioni
Tissue specificityi
Expressed in the brain, where it is localized principally in the ependymal cell layer, choroid plexus and the area postrema. Also found in spinal cord and in the eye.1 Publication
Developmental stagei
First detected at 6 dpc. Predominantly expressed in the developing CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. During gastrulation, it is expressed in the vicinity of the primitive streak, and becomes predominant in that area at late gastrulation. At 10 dpc, detected in ventricular zones (VZ), but not in marginal zones (MZ), and weakly in other structures. Between 12 dpc and 15 dpc, a high expression is present in the VZ in all brain areas. No expression in differentiated neuronal fields. In the newborn and postnatal stages, expression remains restricted to the VZ. Also found weakly in fetal lungs, kidney and epithelia.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000016028, Expressed in molar tooth and 243 other tissues |
ExpressionAtlasi | O35161, baseline and differential |
Genevisiblei | O35161, MM |
Interactioni
Binary interactionsi
O35161
With | #Exp. | IntAct |
---|---|---|
atp6ap2.S [Q7T0S3] from Xenopus laevis. | 2 | EBI-8294650,EBI-8294706 |
Protein-protein interaction databases
BioGRIDi | 198673, 1 interactor |
IntActi | O35161, 1 interactor |
MINTi | O35161 |
STRINGi | 10090.ENSMUSP00000016172 |
Miscellaneous databases
RNActi | O35161, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 261 – 368 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 369 – 474 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 475 – 580 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 581 – 702 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 703 – 804 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 805 – 907 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 908 – 1014 | Cadherin 7PROSITE-ProRule annotationAdd BLAST | 107 | |
Domaini | 1015 – 1116 | Cadherin 8PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 1121 – 1239 | Cadherin 9PROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 1318 – 1376 | EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 1378 – 1414 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1418 – 1456 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1457 – 1661 | Laminin G-like 1PROSITE-ProRule annotationAdd BLAST | 205 | |
Domaini | 1664 – 1700 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1704 – 1885 | Laminin G-like 2PROSITE-ProRule annotationAdd BLAST | 182 | |
Domaini | 1887 – 1922 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1923 – 1961 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1962 – 1994 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 1996 – 2031 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 2018 – 2065 | Laminin EGF-likePROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 2423 – 2475 | GPSPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 222 – 267 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 2295 – 2346 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 2774 – 3034 | DisorderedSequence analysisAdd BLAST | 261 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 222 – 238 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 249 – 266 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 2774 – 2794 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 2814 – 2828 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2889 – 2905 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 2975 – 2989 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 3018 – 3034 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4289, Eukaryota |
GeneTreei | ENSGT00940000159839 |
HOGENOMi | CLU_000158_1_0_1 |
InParanoidi | O35161 |
OMAi | PPAQDTC |
OrthoDBi | 23882at2759 |
PhylomeDBi | O35161 |
TreeFami | TF323983 |
Family and domain databases
CDDi | cd00055, EGF_Lam, 1 hit cd00110, LamG, 2 hits |
Gene3Di | 2.60.220.50, 1 hit 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR032471, GAIN_dom_N IPR046338, GAIN_dom_sf IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR000203, GPS IPR009030, Growth_fac_rcpt_cys_sf IPR001791, Laminin_G IPR002049, LE_dom |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00028, Cadherin, 8 hits PF00008, EGF, 2 hits PF16489, GAIN, 1 hit PF01825, GPS, 1 hit PF02793, HRM, 1 hit PF00053, Laminin_EGF, 1 hit PF02210, Laminin_G_2, 2 hits |
PRINTSi | PR00205, CADHERIN PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00112, CA, 9 hits SM00181, EGF, 6 hits SM00179, EGF_CA, 5 hits SM00180, EGF_Lam, 1 hit SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49313, SSF49313, 9 hits SSF49899, SSF49899, 2 hits SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS00232, CADHERIN_1, 7 hits PS50268, CADHERIN_2, 9 hits PS00022, EGF_1, 6 hits PS01186, EGF_2, 2 hits PS50026, EGF_3, 6 hits PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O35161-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPSSPRVLP ALVLLAAAAL PALELGAAAW ELRVPGGARA FALGPGWSYR
60 70 80 90 100
LDTTRTPREL LDVSREGPAA GRRLGLGAGT LGCARLAGRL LPLQVRLVAR
110 120 130 140 150
GAPTAPSLVL RARAYGARCG VRLLRRSARG AELRSPAVRS VPGLGDALCF
160 170 180 190 200
PAAGGGAASL TSVLEAITNF PACSCPPVAG TGCRRGPICL RPGGSAELRL
210 220 230 240 250
VCALGRAAGA VWVELVIEAT SGTPSESPSV SPSLLNLSQP RAGVVRRSRR
260 270 280 290 300
GTGSSTSPQF PLPSYQVSVP ENEPAGTAVI ELRAHDPDEG DAGRLSYQME
310 320 330 340 350
ALFDERSNGY FLIDAATGAV TTARSLDRET KDTHVLKVSA VDHGSPRRSA
360 370 380 390 400
ATYLTVTVSD TNDHSPVFEQ SEYRERIREN LEVGYEVLTI RATDGDAPSN
410 420 430 440 450
ANMRYRLLEG AGGVFEIDAR SGVVRTRAVV DREEAAEYQL LVEANDQGRN
460 470 480 490 500
PGPLSASATV HIVVEDENDN YPQFSEKRYV VQVPEDVAVN TAVLRVQATD
510 520 530 540 550
RDQGQNAAIH YSIVSGNLKG QFYLHSLSGS LDVINPLDFE AIREYTLRIK
560 570 580 590 600
AQDGGRPPLI NSSGLVSVQV LDVNDNAPIF VSSPFQAAVL ENVPLGHSVL
610 620 630 640 650
HIQAVDADAG ENARLQYRLV DTASTIVGGS SVDSENPASA PDFPFQIHNS
660 670 680 690 700
SGWITVCAEL DREEVEHYSF GVEAVDHGSP AMSSSASVSI TVLDVNDNDP
710 720 730 740 750
MFTQPVYELR LNEDAAVGSS VLTLRARDRD ANSVITYQLT GGNTRNRFAL
760 770 780 790 800
SSQSGGGLIT LALPLDYKQE RQYVLAVTAS DGTRSHTAQV FINVTDANTH
810 820 830 840 850
RPVFQSSHYT VSVSEDRPVG TSIATISATD EDTGENARIT YVLEDPVPQF
860 870 880 890 900
RIDPDTGTIY TMTELDYEDQ AAYTLAITAQ DNGIPQKSDT TSLEILILDA
910 920 930 940 950
NDNAPRFLRD FYQGSVFEDA PPSTSVLQVS ATDRDSGPNG RLLYTFQGGD
960 970 980 990 1000
DGDGDFYIEP TSGVIRTQRR LDRENVAVYN LWALAVDRGS PNPLSASVGI
1010 1020 1030 1040 1050
QVSVLDINDN PPVFEKDELE LFVEENSPVG SVVARIRAND PDEGPNAQIM
1060 1070 1080 1090 1100
YQIVEGNVPE VFQLDLLSGD LRALVELDFE VRRDYMLVVQ ATSAPLVSRA
1110 1120 1130 1140 1150
TVHIRLLDQN DNPPELPDFQ ILFNNYVTNK SNSFPSGVIG RIPAHDPDLS
1160 1170 1180 1190 1200
DSLNYTFLQG NELSLLLLDP ATGELQLSRD LDNNRPLEAL MEVSVSDGIH
1210 1220 1230 1240 1250
SVTALCTLRV TIITDDMLTN SITVRLENMS QEKFLSPLLS LFVEGVATVL
1260 1270 1280 1290 1300
STTKDDIFVF NIQNDTDVSS NILNVTFSAL LPGGTRGRFF PSEDLQEQIY
1310 1320 1330 1340 1350
LNRTLLTTIS AQRVLPFDDN ICLREPCENY MKCVSVLRFD SSAPFISSTT
1360 1370 1380 1390 1400
VLFRPIHPIT GLRCRCPPGF TGDYCETEID LCYSNPCGAN GRCRSREGGY
1410 1420 1430 1440 1450
TCECFEDFTG EHCQVNVRSG RCASGVCKNG GTCVNLLIGG FHCVCPPGEY
1460 1470 1480 1490 1500
EHPYCEVSTR SFPPQSFVTF RGLRQRFHFT VSLAFATQDR NALLLYNGRF
1510 1520 1530 1540 1550
NEKHDFIALE IVEEQLQLTF SAGETTTTVT PQVPGGVSDG RWHSVLVQYY
1560 1570 1580 1590 1600
NKPNIGHLGL PHGPSGEKVA VVTVDDCDAA VAVHFGSYVG NYSCAAQGTQ
1610 1620 1630 1640 1650
SGSKKSLDLT GPLLLGGVPN LPEDFPVHSR QFVGCMRNLS IDGRIVDMAA
1660 1670 1680 1690 1700
FIANNGTRAG CASQRNFCDG TSCQNGGTCV NRWNTYLCEC PLRFGGKNCE
1710 1720 1730 1740 1750
QAMPHPQRFT GESVVLWSDL DITISVPWYL GLMFRTRKED GVLMEATAGT
1760 1770 1780 1790 1800
SSRLHLQILN SYIRFEVSYG PSDVASMQLS KSRITDGGWH HLLIELRSAK
1810 1820 1830 1840 1850
EGKDIKYLAV MTLDYGMDQS TVQIGNQLPG LKMRTIVIGG VTEDKVSVRH
1860 1870 1880 1890 1900
GFRGCMQGVR MGETSTNIAT LNMNDALKVR VKDGCDVEDP CASSPCPPHS
1910 1920 1930 1940 1950
HCRDTWDSYS CICDRGYFGK KCVDACLLNP CKHVAACVRS PNTPRGYSCE
1960 1970 1980 1990 2000
CGPGHYGQYC ENKVDLPCPK GWWGNPVCGP CHCAVSQGFD PDCNKTNGQC
2010 2020 2030 2040 2050
QCKENYYKPP AQDACLPCDC FPHGSHSRAC DMDTGQCACK PGVIGRQCNR
2060 2070 2080 2090 2100
CDNPFAEVTS LGCEVIYNGC PRAFEAGIWW PQTKFGQPAA VPCPKGSVGN
2110 2120 2130 2140 2150
AVRHCSGEKG WLPPELFNCT SGSFVDLKAL NEKLNRNETR MDGNRSLRLA
2160 2170 2180 2190 2200
KALRNATQGN STLFGNDVRT AYQLLARILQ HESRQQGFDL AATREANFHE
2210 2220 2230 2240 2250
DVVHTGSALL APATEASWEQ IQRSEAGAAQ LLRHFEAYFS NVARNVKRTY
2260 2270 2280 2290 2300
LRPFVIVTAN MILAVDIFDK LNFTGAQVPR FEDIQEELPR ELESSVSFPA
2310 2320 2330 2340 2350
DTFKPPEKKE GPVVRLTNRR TTPLTAQPEP RAERETSSSR RRRHPDEPGQ
2360 2370 2380 2390 2400
FAVALVVIYR TLGQLLPEHY DPDHRSLRLP NRPVINTPVV SAMVYSEGTP
2410 2420 2430 2440 2450
LPSSLQRPIL VEFSLLETEE RSKPVCVFWN HSLDTGGTGG WSAKGCELLS
2460 2470 2480 2490 2500
RNRTHVTCQC SHSASCAVLM DISRREHGEV LPLKIITYAA LSLSLVALLV
2510 2520 2530 2540 2550
AFVLLSLVRT LRSNLHSIHK NLITALFFSQ LIFMVGINQT ENPFLCTVVA
2560 2570 2580 2590 2600
ILLHYVSMGT FAWTLVENLH VYRMLTEVRN IDTGPMRFYH VVGWGIPAIV
2610 2620 2630 2640 2650
TGLAVGLDPQ GYGNPDFCWL SLQDTLIWSF AGPVGTVIII NTVIFVLSAK
2660 2670 2680 2690 2700
VSCQRKHHYY ERKGVVSMLR TAFLLLLLVT ATWLLGLLAV NSDTLSFHYL
2710 2720 2730 2740 2750
FAAFSCLQGI FVLLFHCVAH REVRKHLRAV LAGKKLQLDD SATTRATLLT
2760 2770 2780 2790 2800
RSLNCNNTYS EGPDMLRTAL GESTASLDST TRDEGVQKLS VSSGPARGNH
2810 2820 2830 2840 2850
GEPDASFIPR NSKKAHGPDS DSDSELSLDE HSSSYASSHT SDSEDDGGEA
2860 2870 2880 2890 2900
EDKWNPAGGP AHSTPKADAL ANHVPAGWPD ESLAGSDSEE LDTEPHLKVE
2910 2920 2930 2940 2950
TKVSVELHRQ AQGNHCGDRP SDPESGVLAK PVAVLSSQPQ EQRKGILKNK
2960 2970 2980 2990 3000
VTYPPPLPEQ PLKSRLREKL ADCEQSPTSS RTSSLGSGDG VHATDCVITI
3010 3020 3030
KTPRREPGRE HLNGVAMNVR TGSAQANGSD SEKP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BPU9 | A0A2I3BPU9_MOUSE | Cadherin EGF LAG seven-pass G-type ... | Celsr1 | 1,672 | Annotation score: | ||
A0A2I3BQH0 | A0A2I3BQH0_MOUSE | Cadherin EGF LAG seven-pass G-type ... | Celsr1 | 279 | Annotation score: | ||
A0A6I8MX05 | A0A6I8MX05_MOUSE | Cadherin EGF LAG seven-pass G-type ... | Celsr1 | 133 | Annotation score: | ||
A0A6I8MX25 | A0A6I8MX25_MOUSE | Cadherin EGF LAG seven-pass G-type ... | Celsr1 | 201 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 218 | E → Q in AAC68836 (PubMed:9858697).Curated | 1 | |
Sequence conflicti | 1050 | M → I in AAC68836 (PubMed:9858697).Curated | 1 | |
Sequence conflicti | 1900 – 1901 | SH → RP in AAC68836 (PubMed:9858697).Curated | 2 | |
Sequence conflicti | 2524 | T → A in AAC68836 (PubMed:9858697).Curated | 1 | |
Sequence conflicti | 2805 | A → T in AAC68836 (PubMed:9858697).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF031572 mRNA Translation: AAC68836.1 AC116764 Genomic DNA No translation available. AC139513 Genomic DNA No translation available. |
CCDSi | CCDS37172.1 |
PIRi | T14119 |
RefSeqi | NP_034016.2, NM_009886.2 |
Genome annotation databases
Ensembli | ENSMUST00000016172; ENSMUSP00000016172; ENSMUSG00000016028 |
GeneIDi | 12614 |
KEGGi | mmu:12614 |
UCSCi | uc007xdt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF031572 mRNA Translation: AAC68836.1 AC116764 Genomic DNA No translation available. AC139513 Genomic DNA No translation available. |
CCDSi | CCDS37172.1 |
PIRi | T14119 |
RefSeqi | NP_034016.2, NM_009886.2 |
3D structure databases
SMRi | O35161 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198673, 1 interactor |
IntActi | O35161, 1 interactor |
MINTi | O35161 |
STRINGi | 10090.ENSMUSP00000016172 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O35161, 23 sites |
iPTMneti | O35161 |
PhosphoSitePlusi | O35161 |
Proteomic databases
EPDi | O35161 |
MaxQBi | O35161 |
PaxDbi | O35161 |
PeptideAtlasi | O35161 |
PRIDEi | O35161 |
ProteomicsDBi | 281530 |
Protocols and materials databases
Antibodypediai | 13897, 186 antibodies from 29 providers |
DNASUi | 12614 |
Genome annotation databases
Ensembli | ENSMUST00000016172; ENSMUSP00000016172; ENSMUSG00000016028 |
GeneIDi | 12614 |
KEGGi | mmu:12614 |
UCSCi | uc007xdt.1, mouse |
Organism-specific databases
CTDi | 9620 |
MGIi | MGI:1100883, Celsr1 |
VEuPathDBi | HostDB:ENSMUSG00000016028 |
Phylogenomic databases
eggNOGi | KOG4289, Eukaryota |
GeneTreei | ENSGT00940000159839 |
HOGENOMi | CLU_000158_1_0_1 |
InParanoidi | O35161 |
OMAi | PPAQDTC |
OrthoDBi | 23882at2759 |
PhylomeDBi | O35161 |
TreeFami | TF323983 |
Miscellaneous databases
BioGRID-ORCSi | 12614, 5 hits in 76 CRISPR screens |
ChiTaRSi | Celsr1, mouse |
PROi | PR:O35161 |
RNActi | O35161, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000016028, Expressed in molar tooth and 243 other tissues |
ExpressionAtlasi | O35161, baseline and differential |
Genevisiblei | O35161, MM |
Family and domain databases
CDDi | cd00055, EGF_Lam, 1 hit cd00110, LamG, 2 hits |
Gene3Di | 2.60.220.50, 1 hit 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR032471, GAIN_dom_N IPR046338, GAIN_dom_sf IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR000203, GPS IPR009030, Growth_fac_rcpt_cys_sf IPR001791, Laminin_G IPR002049, LE_dom |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00028, Cadherin, 8 hits PF00008, EGF, 2 hits PF16489, GAIN, 1 hit PF01825, GPS, 1 hit PF02793, HRM, 1 hit PF00053, Laminin_EGF, 1 hit PF02210, Laminin_G_2, 2 hits |
PRINTSi | PR00205, CADHERIN PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00112, CA, 9 hits SM00181, EGF, 6 hits SM00179, EGF_CA, 5 hits SM00180, EGF_Lam, 1 hit SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49313, SSF49313, 9 hits SSF49899, SSF49899, 2 hits SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS00232, CADHERIN_1, 7 hits PS50268, CADHERIN_2, 9 hits PS00022, EGF_1, 6 hits PS01186, EGF_2, 2 hits PS50026, EGF_3, 6 hits PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CELR1_MOUSE | |
Accessioni | O35161Primary (citable) accession number: O35161 Secondary accession number(s): E9QK27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 2, 2002 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 192 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families