UniProtKB - O35153 (BET1L_MOUSE)
Protein
BET1-like protein
Gene
Bet1l
Organism
Mus musculus (Mouse)
Status
Functioni
Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).By similarity
GO - Molecular functioni
- SNAP receptor activity Source: MGI
GO - Biological processi
- protein transport Source: UniProtKB-KW
- regulation of retrograde vesicle-mediated transport, Golgi to ER Source: MGI
- retrograde transport, endosome to Golgi Source: MGI
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-6807878, COPI-mediated anterograde transport R-MMU-6811438, Intra-Golgi traffic |
Names & Taxonomyi
Protein namesi | Recommended name: BET1-like proteinAlternative name(s): Golgi SNARE with a size of 15 kDa Short name: GOS-15 Short name: GS15 Vesicle transport protein GOS15 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913128, Bet1l |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type IV membrane protein By similarity
- trans-Golgi network membrane By similarity
Note: Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans-Golgi face of the stacks.By similarity
Cytosol
- cytosol Source: GOC
Endosome
- endosome Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
- Golgi membrane Source: MGI
- Golgi stack Source: MGI
- Golgi trans cisterna Source: GO_Central
- integral component of Golgi membrane Source: MGI
- trans-Golgi network Source: MGI
Other locations
- Golgi-associated vesicle Source: MGI
- SNARE complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 86 | CytoplasmicSequence analysisAdd BLAST | 86 | |
Transmembranei | 87 – 107 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 111 | LumenalSequence analysis | 4 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233057 | 1 – 111 | BET1-like proteinAdd BLAST | 111 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | PhosphoserineBy similarity | 1 | |
Modified residuei | 37 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O35153 |
MaxQBi | O35153 |
PaxDbi | O35153 |
PeptideAtlasi | O35153 |
PRIDEi | O35153 |
PTM databases
iPTMneti | O35153 |
PhosphoSitePlusi | O35153 |
SwissPalmi | O35153 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025484, Expressed in pancreas and 299 other tissues |
Genevisiblei | O35153, MM |
Interactioni
Subunit structurei
Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026557 |
Miscellaneous databases
RNActi | O35153, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 77 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3385, Eukaryota |
GeneTreei | ENSGT00940000160208 |
HOGENOMi | CLU_086133_2_2_1 |
InParanoidi | O35153 |
OMAi | IWASERW |
OrthoDBi | 1536545at2759 |
PhylomeDBi | O35153 |
TreeFami | TF323307 |
Family and domain databases
CDDi | cd15853, SNARE_Bet1, 1 hit |
InterProi | View protein in InterPro IPR039897, BET1 IPR039899, BET1_SNARE IPR000727, T_SNARE_dom |
PANTHERi | PTHR12791, PTHR12791, 1 hit |
PROSITEi | View protein in PROSITE PS50192, T_SNARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
O35153-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADWTRAQSS GAVEDILDRE NKRMADSLAS KVTRLKSLAL DIDRDTEDQN
60 70 80 90 100
RYLDGMDSDF TSVTGLLTGS VKRFSTMARS GRDNRKLLCG MAVVLIVAFF
110
ILSYLLSRTR T
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GQV3 | A0A1B0GQV3_MOUSE | BET1-like protein | Bet1l | 88 | Annotation score: | ||
A0A1B0GS34 | A0A1B0GS34_MOUSE | BET1-like protein | Bet1l | 92 | Annotation score: | ||
A0A1B0GR53 | A0A1B0GR53_MOUSE | BET1-like protein | Bet1l | 47 | Annotation score: | ||
A0A1B0GSF3 | A0A1B0GSF3_MOUSE | BET1-like protein | Bet1l | 49 | Annotation score: | ||
A0A1B0GR52 | A0A1B0GR52_MOUSE | BET1-like protein | Bet1l | 115 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 108 | R → S in BAB27666 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF003999 mRNA Translation: AAB66321.1 AK011508 mRNA Translation: BAB27666.1 AK161239 mRNA Translation: BAE36260.1 |
CCDSi | CCDS21987.1 |
RefSeqi | NP_061212.3, NM_018742.5 |
Genome annotation databases
Ensembli | ENSMUST00000026557; ENSMUSP00000026557; ENSMUSG00000025484 |
GeneIDi | 54399 |
KEGGi | mmu:54399 |
UCSCi | uc009kii.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF003999 mRNA Translation: AAB66321.1 AK011508 mRNA Translation: BAB27666.1 AK161239 mRNA Translation: BAE36260.1 |
CCDSi | CCDS21987.1 |
RefSeqi | NP_061212.3, NM_018742.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026557 |
PTM databases
iPTMneti | O35153 |
PhosphoSitePlusi | O35153 |
SwissPalmi | O35153 |
Proteomic databases
jPOSTi | O35153 |
MaxQBi | O35153 |
PaxDbi | O35153 |
PeptideAtlasi | O35153 |
PRIDEi | O35153 |
Genome annotation databases
Ensembli | ENSMUST00000026557; ENSMUSP00000026557; ENSMUSG00000025484 |
GeneIDi | 54399 |
KEGGi | mmu:54399 |
UCSCi | uc009kii.2, mouse |
Organism-specific databases
CTDi | 51272 |
MGIi | MGI:1913128, Bet1l |
Phylogenomic databases
eggNOGi | KOG3385, Eukaryota |
GeneTreei | ENSGT00940000160208 |
HOGENOMi | CLU_086133_2_2_1 |
InParanoidi | O35153 |
OMAi | IWASERW |
OrthoDBi | 1536545at2759 |
PhylomeDBi | O35153 |
TreeFami | TF323307 |
Enzyme and pathway databases
Reactomei | R-MMU-6807878, COPI-mediated anterograde transport R-MMU-6811438, Intra-Golgi traffic |
Miscellaneous databases
BioGRID-ORCSi | 54399, 1 hit in 17 CRISPR screens |
ChiTaRSi | Bet1l, mouse |
PROi | PR:O35153 |
RNActi | O35153, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025484, Expressed in pancreas and 299 other tissues |
Genevisiblei | O35153, MM |
Family and domain databases
CDDi | cd15853, SNARE_Bet1, 1 hit |
InterProi | View protein in InterPro IPR039897, BET1 IPR039899, BET1_SNARE IPR000727, T_SNARE_dom |
PANTHERi | PTHR12791, PTHR12791, 1 hit |
PROSITEi | View protein in PROSITE PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BET1L_MOUSE | |
Accessioni | O35153Primary (citable) accession number: O35153 Secondary accession number(s): Q9D0E4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot