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Protein

BET1-like protein

Gene

Bet1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: MGI

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
BET1-like protein
Alternative name(s):
Golgi SNARE with a size of 15 kDa
Short name:
GOS-15
Short name:
GS15
Vesicle transport protein GOS15
Gene namesi
Name:Bet1lImported
Synonyms:Gs15Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913128 Bet1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Transmembranei87 – 107Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini108 – 111LumenalSequence analysis4

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330571 – 111BET1-like proteinAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35153
PaxDbiO35153
PeptideAtlasiO35153
PRIDEiO35153

PTM databases

iPTMnetiO35153
PhosphoSitePlusiO35153
SwissPalmiO35153

Expressioni

Gene expression databases

BgeeiENSMUSG00000025484 Expressed in 283 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiO35153 baseline and differential
GenevisibleiO35153 MM

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026557

Structurei

3D structure databases

ProteinModelPortaliO35153
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 77t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3385 Eukaryota
ENOG4111W10 LUCA
GeneTreeiENSGT00570000079186
HOGENOMiHOG000290697
HOVERGENiHBG029661
InParanoidiO35153
KOiK08504
OMAiQNRYLDS
OrthoDBiEOG091G16Y8
PhylomeDBiO35153
TreeFamiTF323307

Family and domain databases

CDDicd15853 SNARE_Bet1, 1 hit
InterProiView protein in InterPro
IPR039897 BET1
IPR039899 BET1_SNARE
IPR000727 T_SNARE_dom
PANTHERiPTHR12791 PTHR12791, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O35153-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADWTRAQSS GAVEDILDRE NKRMADSLAS KVTRLKSLAL DIDRDTEDQN
60 70 80 90 100
RYLDGMDSDF TSVTGLLTGS VKRFSTMARS GRDNRKLLCG MAVVLIVAFF
110
ILSYLLSRTR T
Length:111
Mass (Da):12,428
Last modified:January 1, 1998 - v1
Checksum:i854B3523B71BE5BE
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GQV3A0A1B0GQV3_MOUSE
BET1-like protein
Bet1l
88Annotation score:
A0A1B0GS34A0A1B0GS34_MOUSE
BET1-like protein
Bet1l
92Annotation score:
A0A1B0GR53A0A1B0GR53_MOUSE
BET1-like protein
Bet1l
47Annotation score:
A0A1B0GSF3A0A1B0GSF3_MOUSE
BET1-like protein
Bet1l
49Annotation score:
A0A1B0GR52A0A1B0GR52_MOUSE
BET1-like protein
Bet1l
115Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108R → S in BAB27666 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003999 mRNA Translation: AAB66321.1
AK011508 mRNA Translation: BAB27666.1
AK161239 mRNA Translation: BAE36260.1
CCDSiCCDS21987.1
RefSeqiNP_061212.3, NM_018742.5
UniGeneiMm.155696

Genome annotation databases

EnsembliENSMUST00000026557; ENSMUSP00000026557; ENSMUSG00000025484
GeneIDi54399
KEGGimmu:54399
UCSCiuc009kii.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003999 mRNA Translation: AAB66321.1
AK011508 mRNA Translation: BAB27666.1
AK161239 mRNA Translation: BAE36260.1
CCDSiCCDS21987.1
RefSeqiNP_061212.3, NM_018742.5
UniGeneiMm.155696

3D structure databases

ProteinModelPortaliO35153
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026557

PTM databases

iPTMnetiO35153
PhosphoSitePlusiO35153
SwissPalmiO35153

Proteomic databases

MaxQBiO35153
PaxDbiO35153
PeptideAtlasiO35153
PRIDEiO35153

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026557; ENSMUSP00000026557; ENSMUSG00000025484
GeneIDi54399
KEGGimmu:54399
UCSCiuc009kii.2 mouse

Organism-specific databases

CTDi51272
MGIiMGI:1913128 Bet1l

Phylogenomic databases

eggNOGiKOG3385 Eukaryota
ENOG4111W10 LUCA
GeneTreeiENSGT00570000079186
HOGENOMiHOG000290697
HOVERGENiHBG029661
InParanoidiO35153
KOiK08504
OMAiQNRYLDS
OrthoDBiEOG091G16Y8
PhylomeDBiO35153
TreeFamiTF323307

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSiBet1l mouse
PROiPR:O35153
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025484 Expressed in 283 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiO35153 baseline and differential
GenevisibleiO35153 MM

Family and domain databases

CDDicd15853 SNARE_Bet1, 1 hit
InterProiView protein in InterPro
IPR039897 BET1
IPR039899 BET1_SNARE
IPR000727 T_SNARE_dom
PANTHERiPTHR12791 PTHR12791, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBET1L_MOUSE
AccessioniPrimary (citable) accession number: O35153
Secondary accession number(s): Q9D0E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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