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Protein

Zinc transporter 4

Gene

Slc30a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.

GO - Molecular functioni

GO - Biological processi

  • regulation of sequestering of zinc ion Source: MGI
  • response to toxic substance Source: MGI
  • response to zinc ion Source: GO_Central
  • zinc ion homeostasis Source: MGI
  • zinc ion transmembrane transport Source: GO_Central

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Protein family/group databases

TCDBi2.A.4.3.3 the cation diffusion facilitator (cdf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 4
Short name:
ZnT-4
Alternative name(s):
Lethal milk protein
Solute carrier family 30 member 4
Gene namesi
Name:Slc30a4
Synonyms:Lm, Znt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1345282 Slc30a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 113CytoplasmicSequence analysisAdd BLAST113
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 143VacuolarSequence analysis9
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 178CytoplasmicSequence analysisAdd BLAST14
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 216VacuolarSequence analysisAdd BLAST17
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 275CytoplasmicSequence analysisAdd BLAST38
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 311VacuolarSequence analysisAdd BLAST15
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 430CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Slc30a4 are the cause of the lethal milk (lm) phenotype. Mice with lm are defective in zinc transport into breast milk, due to a premature translation termination codon at position 297. Only homozygous mutant adults develop dermatitis, skin lesions, and hair loss due to a systemic zinc deficiency. However, neonatal mice (of any genotype) suckled on homozygous mutant female also develop symptoms characteristic of nutritional zinc deficiency, including dermatitis, alopecia and stunted growth.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061001 – 430Zinc transporter 4Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35149
MaxQBiO35149
PaxDbiO35149
PRIDEiO35149

PTM databases

iPTMnetiO35149
PhosphoSitePlusiO35149

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in the brain and in mammary epithelial cell lines.

Gene expression databases

BgeeiENSMUSG00000005802 Expressed in 291 organ(s), highest expression level in placenta
ExpressionAtlasiO35149 baseline and differential
GenevisibleiO35149 MM

Interactioni

Protein-protein interaction databases

IntActiO35149, 2 interactors
STRINGi10090.ENSMUSP00000005952

Structurei

3D structure databases

ProteinModelPortaliO35149
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 96Asp-rich (acidic)Add BLAST80
Compositional biasi241 – 249His-rich9

Domaini

Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiO35149
KOiK14691
OMAiELNVWAL
OrthoDBiEOG091G07UN
TreeFamiTF313382

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35149-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPGAWKRL KSLLRKDDTP LFLNDTSAFD FSDEVSDEGL SRFNKLRVVV
60 70 80 90 100
ADDDSEAPER PVNGAHPALQ ADDDSLLDQD LPLTNSQLSL KMDPCDNCSK
110 120 130 140 150
RRELLKQRKV KTRLTIAAVL YLLFMIGELV GGYMANSLAI MTDALHMLTD
160 170 180 190 200
LSAIILTLLA LWLSSKSPTR RFTFGFHRLE VLSAMISVML VYVLMGFLLY
210 220 230 240 250
EAVQRTIHMN YEINGDVMLI TAAVGVAVNV IMGFLLNQSG HHHSHAHSHS
260 270 280 290 300
LPSNSPSMVS SGHNHGQDSL AVRAAFVHAL GDLVQSVGVL IAAYIIRFKP
310 320 330 340 350
EYKIADPICT YIFSLLVAFT TFRIIWDTVV IILEGVPSHL NVDYIKESLM
360 370 380 390 400
KIEDVYSVED LNIWSLTSGK STAIVHMQLI PGSSSKWEEV QSKAKHLLLN
410 420 430
TFGMYKCTIQ LQSYRQEVIR TCANCHSSST
Length:430
Mass (Da):47,800
Last modified:July 27, 2011 - v2
Checksum:iE2311FA6316D15C6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AK40A2AK40_MOUSE
Zinc transporter 4
Slc30a4
381Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti426H → Q in AAB82593 (PubMed:9354792).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004099 Genomic DNA Translation: AAB82413.1
AF003747 mRNA Translation: AAB82593.1
AF004098 Genomic DNA Translation: AAB82412.1
AF004097 Genomic DNA Translation: AAB82411.1
AF004100 Genomic DNA Translation: AAB82414.1
AK134245 mRNA Translation: BAE22062.1
AL772253 Genomic DNA Translation: CAM13308.1
CCDSiCCDS16667.1
RefSeqiNP_001277922.1, NM_001290993.1
NP_035904.2, NM_011774.3
UniGeneiMm.27801

Genome annotation databases

EnsembliENSMUST00000005952; ENSMUSP00000005952; ENSMUSG00000005802
ENSMUST00000216932; ENSMUSP00000151021; ENSMUSG00000111214
GeneIDi22785
KEGGimmu:22785
UCSCiuc008mba.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004099 Genomic DNA Translation: AAB82413.1
AF003747 mRNA Translation: AAB82593.1
AF004098 Genomic DNA Translation: AAB82412.1
AF004097 Genomic DNA Translation: AAB82411.1
AF004100 Genomic DNA Translation: AAB82414.1
AK134245 mRNA Translation: BAE22062.1
AL772253 Genomic DNA Translation: CAM13308.1
CCDSiCCDS16667.1
RefSeqiNP_001277922.1, NM_001290993.1
NP_035904.2, NM_011774.3
UniGeneiMm.27801

3D structure databases

ProteinModelPortaliO35149
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35149, 2 interactors
STRINGi10090.ENSMUSP00000005952

Protein family/group databases

TCDBi2.A.4.3.3 the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetiO35149
PhosphoSitePlusiO35149

Proteomic databases

EPDiO35149
MaxQBiO35149
PaxDbiO35149
PRIDEiO35149

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005952; ENSMUSP00000005952; ENSMUSG00000005802
ENSMUST00000216932; ENSMUSP00000151021; ENSMUSG00000111214
GeneIDi22785
KEGGimmu:22785
UCSCiuc008mba.2 mouse

Organism-specific databases

CTDi7782
MGIiMGI:1345282 Slc30a4

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiO35149
KOiK14691
OMAiELNVWAL
OrthoDBiEOG091G07UN
TreeFamiTF313382

Miscellaneous databases

PROiPR:O35149
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005802 Expressed in 291 organ(s), highest expression level in placenta
ExpressionAtlasiO35149 baseline and differential
GenevisibleiO35149 MM

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZNT4_MOUSE
AccessioniPrimary (citable) accession number: O35149
Secondary accession number(s): O35154, Q3UYZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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