Homeobox protein aristaless-like 4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Physical and genetic interactions between Alx4 and Cart1."
    Qu S., Tucker S.C., Zhao Q., deCrombrugghe B., Wisdom R.
    Development 126:359-369(1999) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Alx4 binding to LEF-1 regulates N-CAM promoter activity."
    Boras K., Hamel P.A.
    J Biol Chem 277:1120-1127(2002) [PubMed] [Europe PMC] [Abstract]
  • "Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions."
    Hudson R., Taniguchi-Sidle A., Boras K., Wiggan O., Hamel P.A.
    Dev Dyn 213:159-169(1998) [PubMed] [Europe PMC] [Abstract]
  • "Physical and genetic interactions between Alx4 and Cart1."
    Qu S., Tucker S.C., Zhao Q., deCrombrugghe B., Wisdom R.
    Development 126:359-369(1999) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• HMG box domain binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors."
    Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
    Nucleic Acids Res 34:1735-1744(2006) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "Physical and genetic interactions between Alx4 and Cart1."
    Qu S., Tucker S.C., Zhao Q., deCrombrugghe B., Wisdom R.
    Development 126:359-369(1999) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions."
    Hudson R., Taniguchi-Sidle A., Boras K., Wiggan O., Hamel P.A.
    Dev Dyn 213:159-169(1998) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI

GO - Biological processⁱ

• anterior/posterior pattern specification Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Polydactyly and ectopic ZPA formation in Alx-4 mutant mice."
    Qu S., Niswender K.D., Ji Q., van der Meer R., Keeney D., Magnuson M.A., Wisdom R.
    Development 124:3999-4008(1997) [PubMed] [Europe PMC] [Abstract]
  • "Physical and genetic interactions between Alx4 and Cart1."
    Qu S., Tucker S.C., Zhao Q., deCrombrugghe B., Wisdom R.
    Development 126:359-369(1999) [PubMed] [Europe PMC] [Abstract]
• digestive tract development Source: MGIInferred from mutant phenotypeⁱ
  • "Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4."
    Dunn N.R., Winnier G.E., Hargett L.K., Schrick J.J., Fogo A.B., Hogan B.L.
    Dev Biol 188:235-247(1997) [PubMed] [Europe PMC] [Abstract]
• embryonic digit morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4."
    Dunn N.R., Winnier G.E., Hargett L.K., Schrick J.J., Fogo A.B., Hogan B.L.
    Dev Biol 188:235-247(1997) [PubMed] [Europe PMC] [Abstract]
• embryonic forelimb morphogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice."
    Beverdam A., Brouwer A., Reijnen M., Korving J., Meijlink F.
    Development 128:3975-3986(2001) [PubMed] [Europe PMC] [Abstract]
• embryonic hindlimb morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice."
    Beverdam A., Brouwer A., Reijnen M., Korving J., Meijlink F.
    Development 128:3975-3986(2001) [PubMed] [Europe PMC] [Abstract]
• embryonic skeletal system morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes."
    Kuijper S., Beverdam A., Kroon C., Brouwer A., Candille S., Barsh G., Meijlink F.
    Development 132:1601-1610(2005) [PubMed] [Europe PMC] [Abstract]
• hair follicle development Source: MGI
• limb morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Polydactyly and ectopic ZPA formation in Alx-4 mutant mice."
    Qu S., Niswender K.D., Ji Q., van der Meer R., Keeney D., Magnuson M.A., Wisdom R.
    Development 124:3999-4008(1997) [PubMed] [Europe PMC] [Abstract]
  • "Physical and genetic interactions between Alx4 and Cart1."
    Qu S., Tucker S.C., Zhao Q., deCrombrugghe B., Wisdom R.
    Development 126:359-369(1999) [PubMed] [Europe PMC] [Abstract]
• muscle organ development Source: MGIInferred from mutant phenotypeⁱ
  • "Polydactyly and ectopic ZPA formation in Alx-4 mutant mice."
    Qu S., Niswender K.D., Ji Q., van der Meer R., Keeney D., Magnuson M.A., Wisdom R.
    Development 124:3999-4008(1997) [PubMed] [Europe PMC] [Abstract]
• pattern specification process Source: MGIInferred from genetic interactionⁱ
  • "Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice."
    Beverdam A., Brouwer A., Reijnen M., Korving J., Meijlink F.
    Development 128:3975-3986(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "Physical and genetic interactions between Alx4 and Cart1."
    Qu S., Tucker S.C., Zhao Q., deCrombrugghe B., Wisdom R.
    Development 126:359-369(1999) [PubMed] [Europe PMC] [Abstract]
• post-embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4."
    Dunn N.R., Winnier G.E., Hargett L.K., Schrick J.J., Fogo A.B., Hogan B.L.
    Dev Biol 188:235-247(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice."
    Beverdam A., Brouwer A., Reijnen M., Korving J., Meijlink F.
    Development 128:3975-3986(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Alx4 binding to LEF-1 regulates N-CAM promoter activity."
    Boras K., Hamel P.A.
    J Biol Chem 277:1120-1127(2002) [PubMed] [Europe PMC] [Abstract]
• roof of mouth development Source: MGIInferred from genetic interactionⁱ
  • "Physical and genetic interactions between Alx4 and Cart1."
    Qu S., Tucker S.C., Zhao Q., deCrombrugghe B., Wisdom R.
    Development 126:359-369(1999) [PubMed] [Europe PMC] [Abstract]
• skeletal system morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Polydactyly and ectopic ZPA formation in Alx-4 mutant mice."
    Qu S., Niswender K.D., Ji Q., van der Meer R., Keeney D., Magnuson M.A., Wisdom R.
    Development 124:3999-4008(1997) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• HMG box domain binding Source: UniProtKBInferred from physical interactionⁱ
  • "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors."
    Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
    Nucleic Acids Res 34:1735-1744(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MNAETCVSYC ESPAAAMDAY YSPVSQSREG SSPFRGFPGG DKFGTTFLSA 
        60         70         80         90        100
GAKGQGFGDA KSRARYGAGQ QDLAAPLESS SGARGSFNKF QPQPPTPQPP 
       110        120        130        140        150
PAPPAPPAHL YLQRGACKTP PDGSLKLQEG SGGHNAALQV PCYAKESNLG 
       160        170        180        190        200
EPELPPDSEP VGMDNSYLSV KETGAKGPQD RASAEIPSPL EKTDSESNKG 
       210        220        230        240        250
KKRRNRTTFT SYQLEELEKV FQKTHYPDVY AREQLAMRTD LTEARVQVWF 
       260        270        280        290        300
QNRRAKWRKR ERFGQMQQVR THFSTAYELP LLTRAENYAQ IQNPSWIGNN 
       310        320        330        340        350
GAASPVPACV VPCDPVPACM SPHAHPPGSG ASSVSDFLSV SGAGSHVGQT 
       360        370        380        390 
HMGSLFGAAG ISPGLNGYEM NGEPDRKTSS IAALRMKAKE HSAAISWAT  

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families