UniProtKB - O35136 (NCAM2_MOUSE)
Protein
Neural cell adhesion molecule 2
Gene
Ncam2
Organism
Mus musculus (Mouse)
Status
Functioni
May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
GO - Molecular functioni
- identical protein binding Source: MGI
GO - Biological processi
- axonal fasciculation Source: Ensembl
- cell adhesion Source: UniProtKB-KW
- sensory perception of smell Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Names & Taxonomyi
Protein namesi | Recommended name: Neural cell adhesion molecule 2Short name: N-CAM-2 Short name: NCAM-2 Alternative name(s): Neural cell adhesion molecule RB-8 R4B12 |
Gene namesi | Name:Ncam2 Synonyms:Ocam, Rncam |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97282 Ncam2 |
Subcellular locationi
Isoform Long :
Plasma membrane
Isoform Short :
Plasma membrane
Nucleus
- nuclear body Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- anchored component of membrane Source: UniProtKB-KW
- axon Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 697 | ExtracellularSequence analysisAdd BLAST | 678 | |
Transmembranei | 698 – 718 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 719 – 837 | CytoplasmicSequence analysisAdd BLAST | 119 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000042589 | 20 – 837 | Neural cell adhesion molecule 2Add BLAST | 818 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Disulfide bondi | 42 ↔ 93 | Curated | |||
Disulfide bondi | 136 ↔ 186 | Curated | |||
Glycosylationi | 177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 219 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 232 ↔ 281 | Curated | |||
Glycosylationi | 309 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 322 ↔ 380 | Curated | |||
Glycosylationi | 406 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 419 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Disulfide bondi | 422 ↔ 475 | Curated | |||
Glycosylationi | 445 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 474 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Glycosylationi | 562 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | ||
Modified residuei | 765 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 780 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 786 | PhosphoserineCombined sources | 1 | ||
Isoform Short (identifier: O35136-2) | |||||
Lipidationi | 703 | GPI-anchor amidated asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, PhosphoproteinProteomic databases
MaxQBi | O35136 |
PaxDbi | O35136 |
PeptideAtlasi | O35136 |
PRIDEi | O35136 |
PTM databases
iPTMneti | O35136 |
PhosphoSitePlusi | O35136 |
SwissPalmi | O35136 |
Expressioni
Tissue specificityi
Expressed in subsets of both olfactory and vomeronasal neurons in a zone-specific manner.
Gene expression databases
Bgeei | ENSMUSG00000022762 Expressed in 139 organ(s), highest expression level in supraoptic nucleus |
Genevisiblei | O35136 MM |
Interactioni
GO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGridi | 201700, 2 interactors |
IntActi | O35136, 3 interactors |
MINTi | O35136 |
STRINGi | 10090.ENSMUSP00000063468 |
Structurei
3D structure databases
ProteinModelPortali | O35136 |
SMRi | O35136 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 108 | Ig-like C2-type 1Add BLAST | 88 | |
Domaini | 113 – 202 | Ig-like C2-type 2Add BLAST | 90 | |
Domaini | 208 – 297 | Ig-like C2-type 3Add BLAST | 90 | |
Domaini | 302 – 396 | Ig-like C2-type 4Add BLAST | 95 | |
Domaini | 401 – 491 | Ig-like C2-type 5Add BLAST | 91 | |
Domaini | 495 – 591 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 593 – 688 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IQJD Eukaryota ENOG41118FG LUCA |
GeneTreei | ENSGT00940000157860 |
HOGENOMi | HOG000074124 |
HOVERGENi | HBG052579 |
InParanoidi | O35136 |
KOi | K06491 |
OMAi | DWRDVKS |
OrthoDBi | 129648at2759 |
PhylomeDBi | O35136 |
TreeFami | TF326195 |
Family and domain databases
CDDi | cd00063 FN3, 2 hits |
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR009138 Neural_cell_adh |
Pfami | View protein in Pfam PF00041 fn3, 2 hits PF07679 I-set, 4 hits |
PRINTSi | PR01838 NCAMFAMILY |
SMARTi | View protein in SMART SM00060 FN3, 2 hits SM00409 IG, 5 hits SM00408 IGc2, 5 hits SM00406 IGv, 3 hits |
SUPFAMi | SSF48726 SSF48726, 5 hits SSF49265 SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853 FN3, 2 hits PS50835 IG_LIKE, 5 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform Long (identifier: O35136-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSLLLSFYLL GLLVRSGQAL LQVTISLSKV ELSVGESKFF TCTAIGEPES
60 70 80 90 100
IDWYNPQGEK IISTQRVMLQ KEGVRSRLTI YNANIEDAGI YRCQATDAKG
110 120 130 140 150
QTQEATVVLE IYQKLTFREV VSPQEFKQGE DAEVVCRVSS SPAPAVSWLY
160 170 180 190 200
HNEEVTTIPD NRFAVLANNN LQILNINKSD EGIYRCEGRV EARGEIDFRD
210 220 230 240 250
IIVIVNVPPA IMMPQKSFNA TAERGEEMTL TCKASGSPDP TISWFRNGKL
260 270 280 290 300
IEENEKYILK GSNTELTVRN IINKDGGSYV CKATNKAGED QKQAFLQVFV
310 320 330 340 350
QPHILQLKNE TTSENGHVTL VCEAEGEPVP EITWKRAIDG VMFSEGDKSP
360 370 380 390 400
DGRIEVKGQH GRSSLHIRDV KLSDSGRYDC EAASRIGGHQ RSMHLDIEYA
410 420 430 440 450
PKFVSNQTMY YSWEGNPINI SCDVTANPPA SIHWRREKLL LPAKNTTHLK
460 470 480 490 500
THSVGRKMIL EIAPTSDNDF GRYNCTATNR IGTRFQEYIL ELADVPSSPH
510 520 530 540 550
GVKIIELSQT TAKISFNKPE SHGGVPIHHY QVDVKEVASE TWKIVRSHGV
560 570 580 590 600
QTMVVLSSLE PNTTYEIRVA AVNGKGQGDY SKIEIFQTLP VREPSPPSIH
610 620 630 640 650
GQPSSGKSFK ISITKQDDGG APILEYIVKY RSKDKEDQWL EKKVQGNKDH
660 670 680 690 700
IILEHLQWTM GYEVQITAAN RLGYSEPTVY EFSMPPKPNI IKDTLFNGLG
710 720 730 740 750
LGAIIGLGVA ALLLILVVTD VSCFFIRQCG LLMCITRRMC GKKSGSSGKS
760 770 780 790 800
KELEEGKAAY LKDGSKEPIV EMRTEDERIT NHEDGSPVNE PNETTPLTEP
810 820 830
EKLPLKEENG KEVLNAETIE IKVSNDIIQS KEDDIKA
Isoform Short (identifier: O35136-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
694-837: TLFNGLGLGA...IQSKEDDIKA → NCCEANKGENGGQSWHLNAVGFTFVITMSLSCLF
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002590 | 694 – 837 | TLFNG…DDIKA → NCCEANKGENGGQSWHLNAV GFTFVITMSLSCLF in isoform Short. 3 PublicationsAdd BLAST | 144 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF001287 mRNA Translation: AAB69125.1 AF001286 mRNA Translation: AAB69124.1 AF016619 mRNA Translation: AAC53375.1 BC119027 mRNA Translation: AAI19028.1 BC119029 mRNA Translation: AAI19030.1 |
CCDSi | CCDS28281.1 [O35136-2] CCDS49888.1 [O35136-1] |
RefSeqi | NP_001106679.1, NM_001113208.1 [O35136-1] NP_035084.1, NM_010954.4 [O35136-2] |
UniGenei | Mm.433941 |
Genome annotation databases
Ensembli | ENSMUST00000037785; ENSMUSP00000049390; ENSMUSG00000022762 [O35136-2] ENSMUST00000067602; ENSMUSP00000063468; ENSMUSG00000022762 [O35136-1] |
GeneIDi | 17968 |
KEGGi | mmu:17968 |
UCSCi | uc007zta.2 mouse [O35136-2] uc007ztb.2 mouse [O35136-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF001287 mRNA Translation: AAB69125.1 AF001286 mRNA Translation: AAB69124.1 AF016619 mRNA Translation: AAC53375.1 BC119027 mRNA Translation: AAI19028.1 BC119029 mRNA Translation: AAI19030.1 |
CCDSi | CCDS28281.1 [O35136-2] CCDS49888.1 [O35136-1] |
RefSeqi | NP_001106679.1, NM_001113208.1 [O35136-1] NP_035084.1, NM_010954.4 [O35136-2] |
UniGenei | Mm.433941 |
3D structure databases
ProteinModelPortali | O35136 |
SMRi | O35136 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 201700, 2 interactors |
IntActi | O35136, 3 interactors |
MINTi | O35136 |
STRINGi | 10090.ENSMUSP00000063468 |
PTM databases
iPTMneti | O35136 |
PhosphoSitePlusi | O35136 |
SwissPalmi | O35136 |
Proteomic databases
MaxQBi | O35136 |
PaxDbi | O35136 |
PeptideAtlasi | O35136 |
PRIDEi | O35136 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000037785; ENSMUSP00000049390; ENSMUSG00000022762 [O35136-2] ENSMUST00000067602; ENSMUSP00000063468; ENSMUSG00000022762 [O35136-1] |
GeneIDi | 17968 |
KEGGi | mmu:17968 |
UCSCi | uc007zta.2 mouse [O35136-2] uc007ztb.2 mouse [O35136-1] |
Organism-specific databases
CTDi | 4685 |
MGIi | MGI:97282 Ncam2 |
Phylogenomic databases
eggNOGi | ENOG410IQJD Eukaryota ENOG41118FG LUCA |
GeneTreei | ENSGT00940000157860 |
HOGENOMi | HOG000074124 |
HOVERGENi | HBG052579 |
InParanoidi | O35136 |
KOi | K06491 |
OMAi | DWRDVKS |
OrthoDBi | 129648at2759 |
PhylomeDBi | O35136 |
TreeFami | TF326195 |
Miscellaneous databases
PROi | PR:O35136 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022762 Expressed in 139 organ(s), highest expression level in supraoptic nucleus |
Genevisiblei | O35136 MM |
Family and domain databases
CDDi | cd00063 FN3, 2 hits |
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR009138 Neural_cell_adh |
Pfami | View protein in Pfam PF00041 fn3, 2 hits PF07679 I-set, 4 hits |
PRINTSi | PR01838 NCAMFAMILY |
SMARTi | View protein in SMART SM00060 FN3, 2 hits SM00409 IG, 5 hits SM00408 IGc2, 5 hits SM00406 IGv, 3 hits |
SUPFAMi | SSF48726 SSF48726, 5 hits SSF49265 SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853 FN3, 2 hits PS50835 IG_LIKE, 5 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | NCAM2_MOUSE | |
Accessioni | O35136Primary (citable) accession number: O35136 Secondary accession number(s): O35962, Q0VF23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 13, 2019 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot