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Protein

Prohibitin-2

Gene

Phb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8949664 Processing of SMDT1

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin-2
Alternative name(s):
B-cell receptor-associated protein BAP37
Repressor of estrogen receptor activity
Gene namesi
Name:Phb2By similarity
Synonyms:BapImported, Bcap37Imported, ReaImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:102520 Phb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002138852 – 299Prohibitin-2Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei128PhosphotyrosineBy similarity1
Modified residuei147N6-acetyllysineCombined sources1
Modified residuei151PhosphoserineBy similarity1
Modified residuei200N6-acetyllysineCombined sources1
Modified residuei236N6-acetyllysineCombined sources1
Modified residuei250N6-acetyllysineBy similarity1
Modified residuei262N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35129
PaxDbiO35129
PeptideAtlasiO35129
PRIDEiO35129
TopDownProteomicsiO35129

2D gel databases

REPRODUCTION-2DPAGEiO35129

PTM databases

iPTMnetiO35129
PhosphoSitePlusiO35129
SwissPalmiO35129

Expressioni

Tissue specificityi

Widely expressed in different tissues.3 Publications

Developmental stagei

Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000004264 Expressed in 299 organ(s), highest expression level in optic fissure
CleanExiMM_PHB2
ExpressionAtlasiO35129 baseline and differential
GenevisibleiO35129 MM

Interactioni

Subunit structurei

Interacts with PHB (PubMed:11302691). Interacts with ESR1, HDAC1 and HDAC5 (PubMed:12878603, PubMed:15140878). Interacts with ZNF703 (By similarity). Interacts with STOML2 (By similarity). Interacts with ARFGEF3 (By similarity).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Rab32Q9CZE34EBI-445002,EBI-11566047

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198310, 15 interactors
IntActiO35129, 15 interactors
MINTiO35129
STRINGi10090.ENSMUSP00000004375

Structurei

3D structure databases

ProteinModelPortaliO35129
SMRiO35129
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 49Necessary for transcriptional repressionBy similarityAdd BLAST31
Regioni150 – 174Necessary for transcriptional repressionBy similarityAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 238Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the prohibitin family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3090 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000075076
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiO35129
KOiK17081
OMAiELGTDYD
OrthoDBiEOG091G0IHW
PhylomeDBiO35129
TreeFamiTF354230

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

O35129-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQNLKDLAG RLPAGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI
60 70 80 90 100
FFNRIGGVQQ DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ
110 120 130 140 150
MVNISLRVLS RPNAQELPSM YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA
160 170 180 190 200
SQLITQRAQV SLLIRRELTE RAKDFSLILD DVAITELSFS REYTAAVEAK
210 220 230 240 250
QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE ALSKNPGYIK
260 270 280 290
LRKIRAAQNI SKTIATSQNR IYLTADNLVL NLQDESFTRG SDSLIKGKK
Length:299
Mass (Da):33,296
Last modified:January 1, 1998 - v1
Checksum:iA887CC982BF85C80
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6QPR1F6QPR1_MOUSE
Prohibitin-2
Phb2
157Annotation score:
F6Q8V7F6Q8V7_MOUSE
Prohibitin-2
Phb2
104Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67 – 68GL → F in CAA55350 (PubMed:8070406).Curated2
Sequence conflicti81Y → N in AAC36528 (PubMed:9798653).Curated1
Sequence conflicti112P → L in AAC36528 (PubMed:9798653).Curated1
Sequence conflicti120M → I in AAC36528 (PubMed:9798653).Curated1
Sequence conflicti127D → G in AAC36528 (PubMed:9798653).Curated1
Sequence conflicti138N → S in AAC36528 (PubMed:9798653).Curated1
Sequence conflicti148F → V in AAC36528 (PubMed:9798653).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78683 mRNA Translation: CAA55350.1
AY319418 mRNA Translation: AAP86652.1
AY211613 mRNA Translation: AAP47231.1
AC002397 Genomic DNA Translation: AAC36005.1
U89422 mRNA Translation: AAC36528.1
CCDSiCCDS39627.1
PIRiS46996
RefSeqiNP_031557.2, NM_007531.2
UniGeneiMm.36241

Genome annotation databases

EnsembliENSMUST00000004375; ENSMUSP00000004375; ENSMUSG00000004264
GeneIDi12034
KEGGimmu:12034
UCSCiuc033iuq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78683 mRNA Translation: CAA55350.1
AY319418 mRNA Translation: AAP86652.1
AY211613 mRNA Translation: AAP47231.1
AC002397 Genomic DNA Translation: AAC36005.1
U89422 mRNA Translation: AAC36528.1
CCDSiCCDS39627.1
PIRiS46996
RefSeqiNP_031557.2, NM_007531.2
UniGeneiMm.36241

3D structure databases

ProteinModelPortaliO35129
SMRiO35129
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198310, 15 interactors
IntActiO35129, 15 interactors
MINTiO35129
STRINGi10090.ENSMUSP00000004375

PTM databases

iPTMnetiO35129
PhosphoSitePlusiO35129
SwissPalmiO35129

2D gel databases

REPRODUCTION-2DPAGEiO35129

Proteomic databases

EPDiO35129
PaxDbiO35129
PeptideAtlasiO35129
PRIDEiO35129
TopDownProteomicsiO35129

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004375; ENSMUSP00000004375; ENSMUSG00000004264
GeneIDi12034
KEGGimmu:12034
UCSCiuc033iuq.1 mouse

Organism-specific databases

CTDi11331
MGIiMGI:102520 Phb2

Phylogenomic databases

eggNOGiKOG3090 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000075076
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiO35129
KOiK17081
OMAiELGTDYD
OrthoDBiEOG091G0IHW
PhylomeDBiO35129
TreeFamiTF354230

Enzyme and pathway databases

ReactomeiR-MMU-8949664 Processing of SMDT1

Miscellaneous databases

ChiTaRSiPhb2 mouse
PROiPR:O35129
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004264 Expressed in 299 organ(s), highest expression level in optic fissure
CleanExiMM_PHB2
ExpressionAtlasiO35129 baseline and differential
GenevisibleiO35129 MM

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHB2_MOUSE
AccessioniPrimary (citable) accession number: O35129
Secondary accession number(s): O89075, Q61336
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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