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Protein

Leucine-rich repeat-containing protein 23

Gene

Lrrc23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 23
Alternative name(s):
Leucine-rich protein B7
Gene namesi
Name:Lrrc23
Synonyms:Lrpb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1315192 Lrrc23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642371 – 340Leucine-rich repeat-containing protein 23Add BLAST340

Proteomic databases

MaxQBiO35125
PaxDbiO35125
PRIDEiO35125

PTM databases

PhosphoSitePlusiO35125

Expressioni

Gene expression databases

BgeeiENSMUSG00000030125 Expressed in 76 organ(s), highest expression level in testis
CleanExiMM_LRRC23
ExpressionAtlasiO35125 baseline and differential
GenevisibleiO35125 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032218

Structurei

3D structure databases

ProteinModelPortaliO35125
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati89 – 110LRR 1Add BLAST22
Repeati111 – 134LRR 2Add BLAST24
Repeati177 – 197LRR 3Add BLAST21
Repeati198 – 219LRR 4Add BLAST22
Repeati220 – 241LRR 5Add BLAST22
Repeati243 – 264LRR 6Add BLAST22
Domaini277 – 315LRRCTAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili305 – 328Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150985
HOGENOMiHOG000006511
HOVERGENiHBG052867
InParanoidiO35125
OMAiLVQMAHL
OrthoDBiEOG091G0DWM
PhylomeDBiO35125
TreeFamiTF329158

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35125-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDEDDVDDV DAEQDEVESD KEIEEWEDYR KETEEASEEW LPTPITEAMM
60 70 80 90 100
KEGLSLLCKI GSGLAHAYIK LEAKDRDLTD ISLLRSYIHL RYVDISENHI
110 120 130 140 150
TDISPLNSLT HLLWLKADGN QLRSARMNEL PYLQIASFSY NQIIDTEGIF
160 170 180 190 200
HPRLGSLDLK GNRIHQVTGL DPERLSSLHT LELRGNQLES TKGIYLPKLK
210 220 230 240 250
NLYLAQNLLK KVEGLENLSN LTTLHLRDNQ IETLNGFSQE MKSLQYLNLR
260 270 280 290 300
SNMISDLAEL AKLRDLPKLR ALVLLDNPCA DETDYRQEAL VQMAHLERLD
310 320 330 340
KEFYEDDDRA EAEEIRQRLK EEQDQDLDPD QDMEPYLPPV
Length:340
Mass (Da):39,292
Last modified:January 1, 1998 - v1
Checksum:iAD81FFB8D96AA650
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6G0D3Z6G0_MOUSE
Leucine-rich repeat-containing prot...
Lrrc23
103Annotation score:
D3Z182D3Z182_MOUSE
Leucine-rich repeat-containing prot...
Lrrc23
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002397 Genomic DNA Translation: AAC36001.1
BC049601 mRNA Translation: AAH49601.1
CCDSiCCDS20528.1
RefSeqiNP_001289484.1, NM_001302555.1
XP_006505722.1, XM_006505659.3
XP_006505723.1, XM_006505660.3
XP_006505726.1, XM_006505663.3
XP_011239541.1, XM_011241239.2
XP_011239542.1, XM_011241240.2
UniGeneiMm.3207

Genome annotation databases

EnsembliENSMUST00000032218; ENSMUSP00000032218; ENSMUSG00000030125
ENSMUST00000112475; ENSMUSP00000108094; ENSMUSG00000030125
GeneIDi16977
KEGGimmu:16977
UCSCiuc009drv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002397 Genomic DNA Translation: AAC36001.1
BC049601 mRNA Translation: AAH49601.1
CCDSiCCDS20528.1
RefSeqiNP_001289484.1, NM_001302555.1
XP_006505722.1, XM_006505659.3
XP_006505723.1, XM_006505660.3
XP_006505726.1, XM_006505663.3
XP_011239541.1, XM_011241239.2
XP_011239542.1, XM_011241240.2
UniGeneiMm.3207

3D structure databases

ProteinModelPortaliO35125
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032218

PTM databases

PhosphoSitePlusiO35125

Proteomic databases

MaxQBiO35125
PaxDbiO35125
PRIDEiO35125

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032218; ENSMUSP00000032218; ENSMUSG00000030125
ENSMUST00000112475; ENSMUSP00000108094; ENSMUSG00000030125
GeneIDi16977
KEGGimmu:16977
UCSCiuc009drv.2 mouse

Organism-specific databases

CTDi10233
MGIiMGI:1315192 Lrrc23

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150985
HOGENOMiHOG000006511
HOVERGENiHBG052867
InParanoidiO35125
OMAiLVQMAHL
OrthoDBiEOG091G0DWM
PhylomeDBiO35125
TreeFamiTF329158

Miscellaneous databases

PROiPR:O35125
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030125 Expressed in 76 organ(s), highest expression level in testis
CleanExiMM_LRRC23
ExpressionAtlasiO35125 baseline and differential
GenevisibleiO35125 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRC23_MOUSE
AccessioniPrimary (citable) accession number: O35125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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