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Protein

GDNF family receptor alpha-3

Gene

Gfra3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase (By similarity).By similarity

GO - Molecular functioni

  • axon guidance receptor activity Source: MGI
  • coreceptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-3
Short name:
GDNF receptor alpha-3
Short name:
GDNFR-alpha-3
Short name:
GFR-alpha-3
Gene namesi
Name:Gfra3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1201403 Gfra3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001079129 – 371GDNF family receptor alpha-3Add BLAST343
PropeptideiPRO_0000010792372 – 397Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi371GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO35118
PRIDEiO35118

PTM databases

PhosphoSitePlusiO35118

Expressioni

Gene expression databases

BgeeiENSMUSG00000024366 Expressed in 105 organ(s), highest expression level in dorsal root ganglion
GenevisibleiO35118 MM

Interactioni

Protein-protein interaction databases

BioGridi199906, 1 interactor
STRINGi10090.ENSMUSP00000025224

Structurei

3D structure databases

ProteinModelPortaliO35118
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIBW Eukaryota
ENOG4111VG4 LUCA
GeneTreeiENSGT00550000074579
HOGENOMiHOG000059598
HOVERGENiHBG051726
InParanoidiO35118
OMAiLFSQDWA
OrthoDBiEOG091G087B
PhylomeDBiO35118
TreeFamiTF331647

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003505 GDNF_rcpt_A3
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 3 hits
PRINTSiPR01319 GDNFRALPHA3
PR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 3 hits
SUPFAMiSSF110035 SSF110035, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35118-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLSWSPRPP LLMILLLVLS LWLPLGAGNS LATENRFVNS CTQARKKCEA
60 70 80 90 100
NPACKAAYQH LGSCTSSLSR PLPLEESAMS ADCLEAAEQL RNSSLIDCRC
110 120 130 140 150
HRRMKHQATC LDIYWTVHPA RSLGDYELDV SPYEDTVTSK PWKMNLSKLN
160 170 180 190 200
MLKPDSDLCL KFAMLCTLHD KCDRLRKAYG EACSGIRCQR HLCLAQLRSF
210 220 230 240 250
FEKAAESHAQ GLLLCPCAPE DAGCGERRRN TIAPSCALPS VTPNCLDLRS
260 270 280 290 300
FCRADPLCRS RLMDFQTHCH PMDILGTCAT EQSRCLRAYL GLIGTAMTPN
310 320 330 340 350
FISKVNTTVA LSCTCRGSGN LQDECEQLER SFSQNPCLVE AIAAKMRFHR
360 370 380 390
QLFSQDWADS TFSVVQQQNS NPALRLQPRL PILSFSILPL ILLQTLW
Length:397
Mass (Da):44,307
Last modified:January 1, 1998 - v1
Checksum:iBB66CEF65D32A4B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 6WS → LE in AAC23558 (PubMed:9749804).Curated2
Sequence conflicti5 – 6WS → LE in AAC24468 (PubMed:9448325).Curated2
Sequence conflicti66S → C in BAC32778 (PubMed:16141072).Curated1
Sequence conflicti218A → P in AAC23558 (PubMed:9749804).Curated1
Sequence conflicti218A → P in AAC24468 (PubMed:9448325).Curated1
Sequence conflicti218A → P in AAB70931 (PubMed:9608533).Curated1
Sequence conflicti314T → S in AAH66202 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008833 mRNA Translation: BAA23562.1
AF041842 mRNA Translation: AAC23558.1
AF036163 mRNA Translation: AAC24468.1
AF051766 mRNA Translation: AAC24354.1
AF020305 mRNA Translation: AAB70931.1
AK046542 mRNA Translation: BAC32778.1
BC066202 mRNA Translation: AAH66202.1
CCDSiCCDS29133.1
PIRiJE0082
RefSeqiNP_034410.3, NM_010280.4
UniGeneiMm.16520

Genome annotation databases

EnsembliENSMUST00000025224; ENSMUSP00000025224; ENSMUSG00000024366
GeneIDi14587
KEGGimmu:14587
UCSCiuc008ele.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008833 mRNA Translation: BAA23562.1
AF041842 mRNA Translation: AAC23558.1
AF036163 mRNA Translation: AAC24468.1
AF051766 mRNA Translation: AAC24354.1
AF020305 mRNA Translation: AAB70931.1
AK046542 mRNA Translation: BAC32778.1
BC066202 mRNA Translation: AAH66202.1
CCDSiCCDS29133.1
PIRiJE0082
RefSeqiNP_034410.3, NM_010280.4
UniGeneiMm.16520

3D structure databases

ProteinModelPortaliO35118
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199906, 1 interactor
STRINGi10090.ENSMUSP00000025224

PTM databases

PhosphoSitePlusiO35118

Proteomic databases

PaxDbiO35118
PRIDEiO35118

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025224; ENSMUSP00000025224; ENSMUSG00000024366
GeneIDi14587
KEGGimmu:14587
UCSCiuc008ele.2 mouse

Organism-specific databases

CTDi2676
MGIiMGI:1201403 Gfra3

Phylogenomic databases

eggNOGiENOG410IIBW Eukaryota
ENOG4111VG4 LUCA
GeneTreeiENSGT00550000074579
HOGENOMiHOG000059598
HOVERGENiHBG051726
InParanoidiO35118
OMAiLFSQDWA
OrthoDBiEOG091G087B
PhylomeDBiO35118
TreeFamiTF331647

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Miscellaneous databases

PROiPR:O35118
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024366 Expressed in 105 organ(s), highest expression level in dorsal root ganglion
GenevisibleiO35118 MM

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003505 GDNF_rcpt_A3
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 3 hits
PRINTSiPR01319 GDNFRALPHA3
PR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 3 hits
SUPFAMiSSF110035 SSF110035, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGFRA3_MOUSE
AccessioniPrimary (citable) accession number: O35118
Secondary accession number(s): O35325
, O55243, Q6NZC2, Q8C8L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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