UniProtKB - O35111 (KCNK3_MOUSE)
Protein
Potassium channel subfamily K member 3
Gene
Kcnk3
Organism
Mus musculus (Mouse)
Status
Functioni
pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.By similarity
Miscellaneous
Inactivated by barium.
GO - Molecular functioni
- ion channel activity Source: MGI
- open rectifier potassium channel activity Source: MGI
- potassium ion leak channel activity Source: UniProtKB
- protein C-terminus binding Source: MGI
- S100 protein binding Source: MGI
GO - Biological processi
- brain development Source: Ensembl
- cellular response to hypoxia Source: MGI
- cellular response to zinc ion Source: Ensembl
- cochlea development Source: Ensembl
- ion transmembrane transport Source: MGI
- negative regulation of cytosolic calcium ion concentration Source: MGI
- potassium ion transmembrane transport Source: GO_Central
- potassium ion transport Source: MGI
- response to drug Source: MGI
- stabilization of membrane potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
Reactomei | R-MMU-1299316, TWIK-releated acid-sensitive K+ channel (TASK) R-MMU-5576886, Phase 4 - resting membrane potential |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel subfamily K member 3Alternative name(s): Acid-sensitive potassium channel protein TASK-1 Cardiac two pore background K(+) channel TWIK-related acid-sensitive K(+) channel 1 Two pore potassium channel KT3.1 Short name: Two pore K(+) channel KT3.1 cTBAK-1 |
Gene namesi | Name:Kcnk3 Synonyms:Ctbak, Task, Task1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1100509, Kcnk3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Intramembranei | 78 – 101 | Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST | 24 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 158 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 159 – 179 | HelicalSequence analysisAdd BLAST | 21 | |
Intramembranei | 184 – 207 | Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST | 24 | |
Transmembranei | 223 – 243 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 244 – 409 | CytoplasmicSequence analysisAdd BLAST | 166 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101745 | 1 – 409 | Potassium channel subfamily K member 3Add BLAST | 409 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | O35111 |
PeptideAtlasi | O35111 |
PRIDEi | O35111 |
PTM databases
GlyGeni | O35111, 1 site |
iPTMneti | O35111 |
PhosphoSitePlusi | O35111 |
Expressioni
Tissue specificityi
Very strong expression in heart, also detected in kidney, brain, skin, testis, lung, skeletal muscle, small intestine and stomach. Not detected in liver, thymus or spleen.
Gene expression databases
Bgeei | ENSMUSG00000049265, Expressed in adrenal gland and 198 other tissues |
Genevisiblei | O35111, MM |
Interactioni
Subunit structurei
Homodimer. Heterodimer with KCNK1.
By similarityGO - Molecular functioni
- protein C-terminus binding Source: MGI
- S100 protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000098987 |
Miscellaneous databases
RNActi | O35111, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4404, Eukaryota |
GeneTreei | ENSGT00940000158248 |
HOGENOMi | CLU_022504_4_0_1 |
InParanoidi | O35111 |
OMAi | SDTCVEH |
OrthoDBi | 1109218at2759 |
PhylomeDBi | O35111 |
TreeFami | TF313947 |
Family and domain databases
InterProi | View protein in InterPro IPR003280, 2pore_dom_K_chnl IPR003092, 2pore_dom_K_chnl_TASK IPR013099, K_chnl_dom IPR005406, KCNK3 |
PANTHERi | PTHR11003:SF138, PTHR11003:SF138, 1 hit |
Pfami | View protein in Pfam PF07885, Ion_trans_2, 2 hits |
PIRSFi | PIRSF038061, K_channel_subfamily_K_type, 1 hit |
PRINTSi | PR01333, 2POREKCHANEL PR01584, TASK1CHANNEL PR01095, TASKCHANNEL |
i Sequence
Sequence statusi: Complete.
O35111-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPEMIERQR LELRQLELRA
60 70 80 90 100
RYNLSEGGYE ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PSTDGGKVFC MFYALLGIPL TLVMFQSLGE RINTFVRYLL HRAKRGLGMR
160 170 180 190 200
HAEVSMANMV LIGFVSCIST LCIGAAAFSY YERWTFFQAY YYCFITLTTI
210 220 230 240 250
GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN LVVLRFMTMN
260 270 280 290 300
AEDEKRDAEH RALLTHNGQA VGLGGLSCLS GSLGDGVRPR DPVTCAAAAG
310 320 330 340 350
GVGVGVGGSG FRNVYAEVLH FQSMCSCLWY KSREKLQYSI PMIIPRDLST
360 370 380 390 400
SDTCVEHSHS SPGGGGRYSD TPSHPCLCSG TQRSAISSVS TGLHSLAAFR
GLMKRRSSV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | Q → E in AAC53367 (PubMed:9312005).Curated | 1 | |
Sequence conflicti | 123 | V → I in AAC53367 (PubMed:9312005).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB008537 mRNA Translation: BAA25436.1 AF241798, AF242508 Genomic DNA Translation: AAF81418.1 AF065162 mRNA Translation: AAG29339.1 AF006824 mRNA Translation: AAC53367.1 AB013345 mRNA Translation: BAA28349.1 |
CCDSi | CCDS19160.1 |
RefSeqi | NP_034738.1, NM_010608.2 |
Genome annotation databases
Ensembli | ENSMUST00000066295; ENSMUSP00000098987; ENSMUSG00000049265 |
GeneIDi | 16527 |
KEGGi | mmu:16527 |
UCSCi | uc008wvr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB008537 mRNA Translation: BAA25436.1 AF241798, AF242508 Genomic DNA Translation: AAF81418.1 AF065162 mRNA Translation: AAG29339.1 AF006824 mRNA Translation: AAC53367.1 AB013345 mRNA Translation: BAA28349.1 |
CCDSi | CCDS19160.1 |
RefSeqi | NP_034738.1, NM_010608.2 |
3D structure databases
SMRi | O35111 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000098987 |
PTM databases
GlyGeni | O35111, 1 site |
iPTMneti | O35111 |
PhosphoSitePlusi | O35111 |
Proteomic databases
PaxDbi | O35111 |
PeptideAtlasi | O35111 |
PRIDEi | O35111 |
Protocols and materials databases
ABCDi | O35111, 1 sequenced antibody |
Antibodypediai | 13387, 219 antibodies |
DNASUi | 16527 |
Genome annotation databases
Ensembli | ENSMUST00000066295; ENSMUSP00000098987; ENSMUSG00000049265 |
GeneIDi | 16527 |
KEGGi | mmu:16527 |
UCSCi | uc008wvr.1, mouse |
Organism-specific databases
CTDi | 3777 |
MGIi | MGI:1100509, Kcnk3 |
Phylogenomic databases
eggNOGi | KOG4404, Eukaryota |
GeneTreei | ENSGT00940000158248 |
HOGENOMi | CLU_022504_4_0_1 |
InParanoidi | O35111 |
OMAi | SDTCVEH |
OrthoDBi | 1109218at2759 |
PhylomeDBi | O35111 |
TreeFami | TF313947 |
Enzyme and pathway databases
Reactomei | R-MMU-1299316, TWIK-releated acid-sensitive K+ channel (TASK) R-MMU-5576886, Phase 4 - resting membrane potential |
Miscellaneous databases
BioGRID-ORCSi | 16527, 1 hit in 18 CRISPR screens |
ChiTaRSi | Kcnk3, mouse |
PROi | PR:O35111 |
RNActi | O35111, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049265, Expressed in adrenal gland and 198 other tissues |
Genevisiblei | O35111, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003280, 2pore_dom_K_chnl IPR003092, 2pore_dom_K_chnl_TASK IPR013099, K_chnl_dom IPR005406, KCNK3 |
PANTHERi | PTHR11003:SF138, PTHR11003:SF138, 1 hit |
Pfami | View protein in Pfam PF07885, Ion_trans_2, 2 hits |
PIRSFi | PIRSF038061, K_channel_subfamily_K_type, 1 hit |
PRINTSi | PR01333, 2POREKCHANEL PR01584, TASK1CHANNEL PR01095, TASKCHANNEL |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNK3_MOUSE | |
Accessioni | O35111Primary (citable) accession number: O35111 Secondary accession number(s): O35163 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | August 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families