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Protein

Potassium channel subfamily K member 3

Gene

Kcnk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.By similarity

Miscellaneous

Inactivated by barium.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1299316 TWIK-releated acid-sensitive K+ channel (TASK)
R-MMU-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 3
Alternative name(s):
Acid-sensitive potassium channel protein TASK-1
Cardiac two pore background K(+) channel
TWIK-related acid-sensitive K(+) channel 1
Two pore potassium channel KT3.1
Short name:
Two pore K(+) channel KT3.1
cTBAK-1
Gene namesi
Name:Kcnk3
Synonyms:Ctbak, Task, Task1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1100509 Kcnk3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Intramembranei78 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST24
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Intramembranei184 – 207Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST24
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 409CytoplasmicSequence analysisAdd BLAST166

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017451 – 409Potassium channel subfamily K member 3Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO35111
PeptideAtlasiO35111
PRIDEiO35111

PTM databases

iPTMnetiO35111
PhosphoSitePlusiO35111

Expressioni

Tissue specificityi

Very strong expression in heart, also detected in kidney, brain, skin, testis, lung, skeletal muscle, small intestine and stomach. Not detected in liver, thymus or spleen.

Gene expression databases

BgeeiENSMUSG00000049265 Expressed in 184 organ(s), highest expression level in adrenal gland
CleanExiMM_KCNK3
GenevisibleiO35111 MM

Interactioni

Subunit structurei

Homodimer. Heterodimer with KCNK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098987

Structurei

3D structure databases

ProteinModelPortaliO35111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000231463
HOVERGENiHBG052239
InParanoidiO35111
KOiK04914
OMAiIGFISCM
OrthoDBiEOG091G08DH
PhylomeDBiO35111
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
IPR005406 KCNK3
PANTHERiPTHR11003:SF138 PTHR11003:SF138, 1 hit
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01584 TASK1CHANNEL
PR01095 TASKCHANNEL

Sequencei

Sequence statusi: Complete.

O35111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPEMIERQR LELRQLELRA
60 70 80 90 100
RYNLSEGGYE ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PSTDGGKVFC MFYALLGIPL TLVMFQSLGE RINTFVRYLL HRAKRGLGMR
160 170 180 190 200
HAEVSMANMV LIGFVSCIST LCIGAAAFSY YERWTFFQAY YYCFITLTTI
210 220 230 240 250
GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN LVVLRFMTMN
260 270 280 290 300
AEDEKRDAEH RALLTHNGQA VGLGGLSCLS GSLGDGVRPR DPVTCAAAAG
310 320 330 340 350
GVGVGVGGSG FRNVYAEVLH FQSMCSCLWY KSREKLQYSI PMIIPRDLST
360 370 380 390 400
SDTCVEHSHS SPGGGGRYSD TPSHPCLCSG TQRSAISSVS TGLHSLAAFR

GLMKRRSSV
Length:409
Mass (Da):45,068
Last modified:August 1, 1998 - v2
Checksum:i35236E011AAC5687
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4Q → E in AAC53367 (PubMed:9312005).Curated1
Sequence conflicti123V → I in AAC53367 (PubMed:9312005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008537 mRNA Translation: BAA25436.1
AF241798, AF242508 Genomic DNA Translation: AAF81418.1
AF065162 mRNA Translation: AAG29339.1
AF006824 mRNA Translation: AAC53367.1
AB013345 mRNA Translation: BAA28349.1
CCDSiCCDS19160.1
RefSeqiNP_034738.1, NM_010608.2
UniGeneiMm.439936

Genome annotation databases

EnsembliENSMUST00000066295; ENSMUSP00000098987; ENSMUSG00000049265
GeneIDi16527
KEGGimmu:16527
UCSCiuc008wvr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008537 mRNA Translation: BAA25436.1
AF241798, AF242508 Genomic DNA Translation: AAF81418.1
AF065162 mRNA Translation: AAG29339.1
AF006824 mRNA Translation: AAC53367.1
AB013345 mRNA Translation: BAA28349.1
CCDSiCCDS19160.1
RefSeqiNP_034738.1, NM_010608.2
UniGeneiMm.439936

3D structure databases

ProteinModelPortaliO35111
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098987

PTM databases

iPTMnetiO35111
PhosphoSitePlusiO35111

Proteomic databases

PaxDbiO35111
PeptideAtlasiO35111
PRIDEiO35111

Protocols and materials databases

DNASUi16527
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066295; ENSMUSP00000098987; ENSMUSG00000049265
GeneIDi16527
KEGGimmu:16527
UCSCiuc008wvr.1 mouse

Organism-specific databases

CTDi3777
MGIiMGI:1100509 Kcnk3

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000231463
HOVERGENiHBG052239
InParanoidiO35111
KOiK04914
OMAiIGFISCM
OrthoDBiEOG091G08DH
PhylomeDBiO35111
TreeFamiTF313947

Enzyme and pathway databases

ReactomeiR-MMU-1299316 TWIK-releated acid-sensitive K+ channel (TASK)
R-MMU-5576886 Phase 4 - resting membrane potential

Miscellaneous databases

PROiPR:O35111
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049265 Expressed in 184 organ(s), highest expression level in adrenal gland
CleanExiMM_KCNK3
GenevisibleiO35111 MM

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
IPR005406 KCNK3
PANTHERiPTHR11003:SF138 PTHR11003:SF138, 1 hit
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01584 TASK1CHANNEL
PR01095 TASKCHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiKCNK3_MOUSE
AccessioniPrimary (citable) accession number: O35111
Secondary accession number(s): O35163
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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