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Protein

Osteomodulin

Gene

Omd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta3-integrin (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-2022854 Keratan sulfate biosynthesis
R-MMU-2022857 Keratan sulfate degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name:
KSPG osteomodulin
Osteoadherin
Short name:
OSAD
Gene namesi
Name:Omd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1350918 Omd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003275521 – 423OsteomodulinAdd BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22SulfotyrosineBy similarity1
Modified residuei25SulfotyrosineBy similarity1
Modified residuei31SulfotyrosineBy similarity1
Modified residuei39SulfotyrosineBy similarity1
Modified residuei51SulfotyrosineBy similarity1
Modified residuei77SulfotyrosineBy similarity1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi321 ↔ 353By similarity
Modified residuei413SulfotyrosineBy similarity1
Modified residuei414SulfotyrosineBy similarity1

Post-translational modificationi

Binds keratan sulfate chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

Proteomic databases

MaxQBiO35103
PaxDbiO35103
PRIDEiO35103

PTM databases

PhosphoSitePlusiO35103

Expressioni

Tissue specificityi

Bone specific.

Gene expression databases

BgeeiENSMUSG00000048368 Expressed in 136 organ(s), highest expression level in vault of skull
CleanExiMM_OMD
GenevisibleiO35103 MM

Interactioni

Subunit structurei

Binds the alpha(V)beta3-integrin.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065706

Structurei

3D structure databases

ProteinModelPortaliO35103
SMRiO35103
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 91LRRNTAdd BLAST39
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 129LRR 2Add BLAST14
Repeati142 – 164LRR 3Add BLAST23
Repeati165 – 184LRR 4Add BLAST20
Repeati187 – 207LRR 5Add BLAST21
Repeati213 – 233LRR 6Add BLAST21
Repeati234 – 255LRR 7Add BLAST22
Repeati258 – 279LRR 8Add BLAST22
Repeati281 – 294LRR 9Add BLAST14
Repeati301 – 322LRR 10Add BLAST22
Repeati331 – 353LRR 11Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 78Cys-richAdd BLAST17
Compositional biasi385 – 407Asp/Glu-rich (acidic)Add BLAST23

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiO35103
KOiK08124
OMAiAFYIPRN
OrthoDBiEOG091G044B
PhylomeDBiO35103
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR030705 Osteomodulin
PANTHERiPTHR24373:SF155 PTHR24373:SF155, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35103-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFLSPIYVL FFCFGVRVYC QYEAYRWDDD YDQEPNEDYD PEFQFHQNIE
60 70 80 90 100
YGVPFYNNIL GCAKECFCPT NFPTSMYCDN RKLKTIPIIP MHIQQLNLQF
110 120 130 140 150
NDIEAVTANS FINATHLKEI NLSHNKIKSQ KIDYGVFAKL SNLQQLHLEH
160 170 180 190 200
NNLEEFPFPL PKSLERLLLG YNEISILPTN AMDGLVNVTM LDLCYNHLSD
210 220 230 240 250
SMLKEKTLSK MEKLMQLNLC NNRLESMPLG LPSSLMYLSL ENNSISSIPD
260 270 280 290 300
NYFDKLPKLH ALRISHNKLE DIPYDIFNLS NLIELNVGHN KLKQAFYIPR
310 320 330 340 350
NLEHLYLQNN EIESINVTMI CPSPDPVHHH HLTYLRVDQN KLKEPISSYI
360 370 380 390 400
FFCFPRIHSI YYGEQRSTNG ETIQLKTQVF RSYQEEEEED DHDSQDNTLE
410 420
GQEVSDEHYN SHYYEMQEWQ DTI
Length:423
Mass (Da):49,745
Last modified:January 1, 1998 - v1
Checksum:i41ED7CA6B3A6F3B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007848 mRNA Translation: BAA22790.1
CCDSiCCDS26504.1
RefSeqiNP_036180.1, NM_012050.2
XP_006516991.1, XM_006516928.2
XP_017171009.1, XM_017315520.1
UniGeneiMm.390589

Genome annotation databases

EnsembliENSMUST00000065494; ENSMUSP00000065706; ENSMUSG00000048368
ENSMUST00000221170; ENSMUSP00000152066; ENSMUSG00000048368
GeneIDi27047
KEGGimmu:27047
UCSCiuc007qjp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007848 mRNA Translation: BAA22790.1
CCDSiCCDS26504.1
RefSeqiNP_036180.1, NM_012050.2
XP_006516991.1, XM_006516928.2
XP_017171009.1, XM_017315520.1
UniGeneiMm.390589

3D structure databases

ProteinModelPortaliO35103
SMRiO35103
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065706

PTM databases

PhosphoSitePlusiO35103

Proteomic databases

MaxQBiO35103
PaxDbiO35103
PRIDEiO35103

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065494; ENSMUSP00000065706; ENSMUSG00000048368
ENSMUST00000221170; ENSMUSP00000152066; ENSMUSG00000048368
GeneIDi27047
KEGGimmu:27047
UCSCiuc007qjp.1 mouse

Organism-specific databases

CTDi4958
MGIiMGI:1350918 Omd

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiO35103
KOiK08124
OMAiAFYIPRN
OrthoDBiEOG091G044B
PhylomeDBiO35103
TreeFamiTF334562

Enzyme and pathway databases

ReactomeiR-MMU-2022854 Keratan sulfate biosynthesis
R-MMU-2022857 Keratan sulfate degradation

Miscellaneous databases

PROiPR:O35103
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048368 Expressed in 136 organ(s), highest expression level in vault of skull
CleanExiMM_OMD
GenevisibleiO35103 MM

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR030705 Osteomodulin
PANTHERiPTHR24373:SF155 PTHR24373:SF155, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOMD_MOUSE
AccessioniPrimary (citable) accession number: O35103
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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