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Protein

Homeobox protein ARX

Gene

Arx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi330 – 389HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ARX
Alternative name(s):
Aristaless-related homeobox
Gene namesi
Name:Arx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1097716 Arx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488201 – 564Homeobox protein ARXAdd BLAST564

Proteomic databases

PaxDbiO35085
PRIDEiO35085

PTM databases

PhosphoSitePlusiO35085

Expressioni

Gene expression databases

BgeeiENSMUSG00000035277 Expressed in 140 organ(s), highest expression level in rostral migratory stream
CleanExiMM_ARX
GenevisibleiO35085 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049039

Structurei

3D structure databases

ProteinModelPortaliO35085
SMRiO35085
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi532 – 545OARPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 154Ala-richAdd BLAST55
Compositional biasi223 – 252Glu-richAdd BLAST30
Compositional biasi397 – 461Pro-richAdd BLAST65
Compositional biasi427 – 546Ala-richAdd BLAST120

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000012381
HOVERGENiHBG004285
InParanoidiO35085
KOiK09452
OMAiIGPTFGR
OrthoDBiEOG091G0S4E
PhylomeDBiO35085
TreeFamiTF350743

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequencei

Sequence statusi: Complete.

O35085-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL
60 70 80 90 100
PAPLASRADQ EKAMQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA
110 120 130 140 150
AAAAAAAAAA AAAATATGTA GPRGEVPPPP PPAARPGERQ DSAGAVAAAA
160 170 180 190 200
AAAAWDTLKI SQAPQVSISR SKSYRENGAP FVPPPPALDE LSGPGGVAHP
210 220 230 240 250
EERLSAASGP GSAPAAGGGT GAEDDEEELL EDEEDEEEEE ELLEDDDEEL
260 270 280 290 300
LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAVATEGGE LSPKEELLLH
310 320 330 340 350
PEDAEGKDGE DSVCLSAGSD SEEGLLKRKQ RRYRTTFTSY QLEELERAFQ
360 370 380 390 400
KTHYPDVFTR EELAMRLDLT EARVQVWFQN RRAKWRKREK AGAQTHPPGL
410 420 430 440 450
PFPGPLSATH PLSPYLDASP FPPHHPALDS AWTAAAAAAA AAFPSLPPPP
460 470 480 490 500
GSASLPPSGA PLGLSTFLGA AVFRHPAFIS PAFGRLFSTM APLTSASTAA
510 520 530 540 550
ALLRQPTPAV EGAVASGALA DPATAAADRR ASSIAALRLK AKEHAAQLTQ
560
LNILPGTSTG KEVC
Length:564
Mass (Da):58,490
Last modified:January 27, 2003 - v3
Checksum:i74FEBBD3BA92B39C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59D → E in BAA85852 (Ref. 3) Curated1
Sequence conflicti127P → H in BAA85852 (Ref. 3) Curated1
Sequence conflicti316S → A in BAA85852 (Ref. 3) Curated1
Sequence conflicti360Missing in BAA85852 (Ref. 3) Curated1
Sequence conflicti485Missing in BAA85852 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006103 mRNA Translation: BAA28284.2
AB026674 Genomic DNA Translation: BAA85852.1
AL590876 Genomic DNA Translation: CAM25902.1
BC052033 mRNA Translation: AAH52033.1
CCDSiCCDS30271.1
RefSeqiNP_001292869.1, NM_001305940.1
NP_031518.2, NM_007492.4
UniGeneiMm.275547

Genome annotation databases

EnsembliENSMUST00000046565; ENSMUSP00000049039; ENSMUSG00000035277
ENSMUST00000113947; ENSMUSP00000109580; ENSMUSG00000035277
GeneIDi11878
KEGGimmu:11878
UCSCiuc009tsq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006103 mRNA Translation: BAA28284.2
AB026674 Genomic DNA Translation: BAA85852.1
AL590876 Genomic DNA Translation: CAM25902.1
BC052033 mRNA Translation: AAH52033.1
CCDSiCCDS30271.1
RefSeqiNP_001292869.1, NM_001305940.1
NP_031518.2, NM_007492.4
UniGeneiMm.275547

3D structure databases

ProteinModelPortaliO35085
SMRiO35085
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049039

PTM databases

PhosphoSitePlusiO35085

Proteomic databases

PaxDbiO35085
PRIDEiO35085

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046565; ENSMUSP00000049039; ENSMUSG00000035277
ENSMUST00000113947; ENSMUSP00000109580; ENSMUSG00000035277
GeneIDi11878
KEGGimmu:11878
UCSCiuc009tsq.1 mouse

Organism-specific databases

CTDi170302
MGIiMGI:1097716 Arx

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000012381
HOVERGENiHBG004285
InParanoidiO35085
KOiK09452
OMAiIGPTFGR
OrthoDBiEOG091G0S4E
PhylomeDBiO35085
TreeFamiTF350743

Miscellaneous databases

PROiPR:O35085
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035277 Expressed in 140 organ(s), highest expression level in rostral migratory stream
CleanExiMM_ARX
GenevisibleiO35085 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARX_MOUSE
AccessioniPrimary (citable) accession number: O35085
Secondary accession number(s): A2A4G9, Q9QYT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 27, 2003
Last modified: November 7, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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