UniProtKB - O35075 (VP26C_MOUSE)
Protein
Vacuolar protein sorting-associated protein 26C
Gene
Vps26c
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.By similarity
GO - Biological processi
- endocytic recycling Source: UniProtKB
- intracellular protein transport Source: GO_Central
- retrograde transport, endosome to plasma membrane Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 26CCuratedAlternative name(s): Down syndrome critical region protein 3 homolog Down syndrome critical region protein A homolog |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1206040, Vps26c |
Subcellular locationi
Endosome
- Endosome By similarity
Endosome
- endosome Source: GO_Central
Keywords - Cellular componenti
EndosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073017 | 1 – 297 | Vacuolar protein sorting-associated protein 26CAdd BLAST | 297 |
Proteomic databases
EPDi | O35075 |
MaxQBi | O35075 |
PaxDbi | O35075 |
PeptideAtlasi | O35075 |
PRIDEi | O35075 |
ProteomicsDBi | 277502 |
PTM databases
iPTMneti | O35075 |
PhosphoSitePlusi | O35075 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022898, Expressed in facial nucleus and 327 other tissues |
ExpressionAtlasi | O35075, baseline and differential |
Genevisiblei | O35075, MM |
Interactioni
Subunit structurei
Component of the heterotrimeric retriever complex formed by VPS26C, VPS29 and VPS35L.
Interacts with SNX17; the interaction is direct and associates SNX17 with the retriever complex.
Interacts with SNX31; the interaction is direct.
By similarityProtein-protein interaction databases
IntActi | O35075, 1 interactor |
STRINGi | 10090.ENSMUSP00000023615 |
Miscellaneous databases
RNActi | O35075, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the VPS26 family.Curated
Phylogenomic databases
eggNOGi | KOG2717, Eukaryota |
GeneTreei | ENSGT00950000183064 |
HOGENOMi | CLU_056829_0_0_1 |
InParanoidi | O35075 |
OMAi | FKIEFEV |
OrthoDBi | 1476901at2759 |
PhylomeDBi | O35075 |
TreeFami | TF323199 |
Family and domain databases
Gene3Di | 2.60.40.640, 2 hits |
InterProi | View protein in InterPro IPR014752, Arrestin_C IPR014756, Ig_E-set IPR028934, Vps26-related |
PANTHERi | PTHR12233, PTHR12233, 1 hit |
Pfami | View protein in Pfam PF03643, Vps26, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O35075-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTTLDIKIK RANKVYHAGE MLSGVVVISS KDSVQHQGVS LTMEGTVNLQ
60 70 80 90 100
LSAKSVGVFE AFYNSVKPIQ IINSTIDVLK PGKIPSGKTE VPFEFPLLVK
110 120 130 140 150
GSKVLYETYH GVFVNIQYTL RCDMRRSLLA KDLTKTCEFI VHSAPQKGKL
160 170 180 190 200
TPSPVDFTIT PETLQNVKER ASLPKFFIRG HLNSTNCAIT QPLTGELVVE
210 220 230 240 250
HSDAAIRSIE LQLVRVETCG CAEGYARDAT EIQNIQIADG DICRNLSVPL
260 270 280 290
YMVFPRLFTC PTLETTNFKV EFEVNVVVLL HADHLITENF PLKLCRT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A338P6T5 | A0A338P6T5_MOUSE | Vacuolar protein sorting-associated... | Vps26c | 135 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB001990 mRNA Translation: BAA23270.1 AK077485 mRNA Translation: BAC36824.1 AK077628 mRNA Translation: BAC36911.1 BC003740 mRNA Translation: AAH03740.1 |
CCDSi | CCDS28349.1 |
PIRi | JC5699 |
RefSeqi | NP_031860.1, NM_007834.3 |
Genome annotation databases
Ensembli | ENSMUST00000023615; ENSMUSP00000023615; ENSMUSG00000022898 |
GeneIDi | 13185 |
KEGGi | mmu:13185 |
UCSCi | uc008abe.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB001990 mRNA Translation: BAA23270.1 AK077485 mRNA Translation: BAC36824.1 AK077628 mRNA Translation: BAC36911.1 BC003740 mRNA Translation: AAH03740.1 |
CCDSi | CCDS28349.1 |
PIRi | JC5699 |
RefSeqi | NP_031860.1, NM_007834.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | O35075, 1 interactor |
STRINGi | 10090.ENSMUSP00000023615 |
PTM databases
iPTMneti | O35075 |
PhosphoSitePlusi | O35075 |
Proteomic databases
EPDi | O35075 |
MaxQBi | O35075 |
PaxDbi | O35075 |
PeptideAtlasi | O35075 |
PRIDEi | O35075 |
ProteomicsDBi | 277502 |
Protocols and materials databases
Antibodypediai | 8571, 137 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000023615; ENSMUSP00000023615; ENSMUSG00000022898 |
GeneIDi | 13185 |
KEGGi | mmu:13185 |
UCSCi | uc008abe.2, mouse |
Organism-specific databases
CTDi | 10311 |
MGIi | MGI:1206040, Vps26c |
Phylogenomic databases
eggNOGi | KOG2717, Eukaryota |
GeneTreei | ENSGT00950000183064 |
HOGENOMi | CLU_056829_0_0_1 |
InParanoidi | O35075 |
OMAi | FKIEFEV |
OrthoDBi | 1476901at2759 |
PhylomeDBi | O35075 |
TreeFami | TF323199 |
Miscellaneous databases
BioGRID-ORCSi | 13185, 0 hits in 52 CRISPR screens |
PROi | PR:O35075 |
RNActi | O35075, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022898, Expressed in facial nucleus and 327 other tissues |
ExpressionAtlasi | O35075, baseline and differential |
Genevisiblei | O35075, MM |
Family and domain databases
Gene3Di | 2.60.40.640, 2 hits |
InterProi | View protein in InterPro IPR014752, Arrestin_C IPR014756, Ig_E-set IPR028934, Vps26-related |
PANTHERi | PTHR12233, PTHR12233, 1 hit |
Pfami | View protein in Pfam PF03643, Vps26, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VP26C_MOUSE | |
Accessioni | O35075Primary (citable) accession number: O35075 Secondary accession number(s): Q542V5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families