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Protein

Kinesin-like protein KIF1C

Gene

Kif1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF1C
Gene namesi
Name:Kif1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1098260 Kif1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254111 – 1100Kinesin-like protein KIF1CAdd BLAST1100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295PhosphoserineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei674PhosphoserineCombined sources1
Modified residuei676PhosphoserineCombined sources1
Modified residuei914PhosphoserineBy similarity1
Modified residuei1031PhosphoserineBy similarity1
Modified residuei1039Omega-N-methylarginineCombined sources1
Modified residuei1080PhosphothreonineBy similarity1
Modified residuei1089PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO35071
MaxQBiO35071
PaxDbiO35071
PeptideAtlasiO35071
PRIDEiO35071

PTM databases

iPTMnetiO35071
PhosphoSitePlusiO35071

Expressioni

Gene expression databases

BgeeiENSMUSG00000020821 Expressed in 289 organ(s), highest expression level in muscle tissue
CleanExiMM_KIF1C
ExpressionAtlasiO35071 baseline and differential
GenevisibleiO35071 MM

Interactioni

Subunit structurei

Monomer.Curated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200937, 20 interactors
IntActiO35071, 20 interactors
STRINGi10090.ENSMUSP00000092075

Structurei

3D structure databases

ProteinModelPortaliO35071
SMRiO35071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 348Kinesin motorPROSITE-ProRule annotationAdd BLAST344
Domaini523 – 590FHAAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili359 – 381Sequence analysisAdd BLAST23
Coiled coili438 – 479Sequence analysisAdd BLAST42
Coiled coili634 – 671Sequence analysisAdd BLAST38
Coiled coili827 – 871Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi964 – 1082Pro-richAdd BLAST119

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOVERGENiHBG057158
InParanoidiO35071
KOiK10392
PhylomeDBiO35071
TreeFamiTF105221

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR027640 Kinesin-like_fam
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O35071-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF
60 70 80 90 100
TFDYSYWSHT SVEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGR QEPGQQGIVP QLCEDLFSRV NVNQSAQLSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KSRGSLRVRE HPILGPYVQD LSKLAVTSYA DIADLMDCGN
210 220 230 240 250
KARTVAATNM NETSSRSHAV FTIVFTQRSH DQLTGLDSEK VSKISLVDLA
260 270 280 290 300
GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADLQS KKRKSDFIPY
310 320 330 340 350
RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC
360 370 380 390 400
NAVINEDPNA RLIRELQEEV ARLRDLLMAQ GLSASALGGL KVEEGSPGGV
410 420 430 440 450
LPPASSPPAP ASPSSPPPHN GELEPSFSPS AEPQIGPEEA MERLQETEKI
460 470 480 490 500
IAELNETWEE KLRKTEALRM EREALLAEMG VAVREDGGTV GVFSPKKTPH
510 520 530 540 550
LVNLNEDPLM SECLLYHIKD GVTRVGQVDV DIKLTGQFIR EQHCLFRSIP
560 570 580 590 600
QPDGEVMVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP
610 620 630 640 650
EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL
660 670 680 690 700
ENQYRKEKEE ADLLLEQQRL YADSDSGEDS DKRSCEESWR LISSLREQLP
710 720 730 740 750
PTTVQNIVKR CGLPSSGKRR APRRVYQIPQ RRRLQGKDPR WATMADLKMQ
760 770 780 790 800
AVKEICYEVA LADFRHGRAE IEALAALKMR ELCRTYGKPE GPGDAWRAVA
810 820 830 840 850
RDVWDTVGEE EGCGGGGGGS EEGARGAEVE DLRAHIDKLT GILQEVKLQN
860 870 880 890 900
SSKDRELQAL RDRMLRMERV IPLTQDLEDD NDESGLVTWA PPEGPEAVEE
910 920 930 940 950
TVPNDHSPAV RPTSPPLSSW ERVSRLMEED PAFRRGRLRW LKQEQLRLQG
960 970 980 990 1000
LQGAGGRGGG LRRPPARFVP PHDCKLRFPF KSNPQHRESW PGMGSGEAPA
1010 1020 1030 1040 1050
PQPPEEVTVP PAPPNRRPPS PRRPHRSRRN SLDGGSRSRG GGSTQPEPQH
1060 1070 1080 1090 1100
LRPQKHNGYP QQPQPSPAQR PGPRYPPYTT PPRMRRQRSA PDLKESGAAV
Length:1,100
Mass (Da):122,434
Last modified:October 11, 2005 - v2
Checksum:iE92CFFECE6D0F0DA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3V3Y9Q3V3Y9_MOUSE
Kinesin-like protein
Kif1c
425Annotation score:
E9Q9B0E9Q9B0_MOUSE
Kinesin-like protein KIF1C
Kif1c
1,112Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596117 Genomic DNA No translation available.
AB001456 mRNA Translation: BAA22398.1
CCDSiCCDS24965.1
RefSeqiNP_694743.2, NM_153103.2
XP_006532383.1, XM_006532320.3
XP_006532384.1, XM_006532321.3
XP_006532385.1, XM_006532322.3
UniGeneiMm.99996

Genome annotation databases

EnsembliENSMUST00000094499; ENSMUSP00000092075; ENSMUSG00000020821
ENSMUST00000102554; ENSMUSP00000099614; ENSMUSG00000020821
ENSMUST00000137119; ENSMUSP00000123242; ENSMUSG00000020821
GeneIDi16562
KEGGimmu:16562
UCSCiuc007jwl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596117 Genomic DNA No translation available.
AB001456 mRNA Translation: BAA22398.1
CCDSiCCDS24965.1
RefSeqiNP_694743.2, NM_153103.2
XP_006532383.1, XM_006532320.3
XP_006532384.1, XM_006532321.3
XP_006532385.1, XM_006532322.3
UniGeneiMm.99996

3D structure databases

ProteinModelPortaliO35071
SMRiO35071
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200937, 20 interactors
IntActiO35071, 20 interactors
STRINGi10090.ENSMUSP00000092075

PTM databases

iPTMnetiO35071
PhosphoSitePlusiO35071

Proteomic databases

EPDiO35071
MaxQBiO35071
PaxDbiO35071
PeptideAtlasiO35071
PRIDEiO35071

Protocols and materials databases

DNASUi16562
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094499; ENSMUSP00000092075; ENSMUSG00000020821
ENSMUST00000102554; ENSMUSP00000099614; ENSMUSG00000020821
ENSMUST00000137119; ENSMUSP00000123242; ENSMUSG00000020821
GeneIDi16562
KEGGimmu:16562
UCSCiuc007jwl.1 mouse

Organism-specific databases

CTDi10749
MGIiMGI:1098260 Kif1c

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOVERGENiHBG057158
InParanoidiO35071
KOiK10392
PhylomeDBiO35071
TreeFamiTF105221

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

ChiTaRSiKif1c mouse
PROiPR:O35071
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020821 Expressed in 289 organ(s), highest expression level in muscle tissue
CleanExiMM_KIF1C
ExpressionAtlasiO35071 baseline and differential
GenevisibleiO35071 MM

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR027640 Kinesin-like_fam
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF1C_MOUSE
AccessioniPrimary (citable) accession number: O35071
Secondary accession number(s): Q5SX62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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