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Protein

Kinesin-like protein KIF3C

Gene

Kif3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • kinesin binding Source: MGI
  • microtubule binding Source: MGI
  • microtubule motor activity Source: GO_Central

GO - Biological processi

  • microtubule-based movement Source: GO_Central
  • organelle transport along microtubule Source: MGI
  • positive regulation of neuron projection development Source: MGI

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-5620924 Intraflagellar transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3C
Gene namesi
Name:Kif3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:107979 Kif3c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253981 – 796Kinesin-like protein KIF3CAdd BLAST796

Proteomic databases

EPDiO35066
MaxQBiO35066
PaxDbiO35066
PeptideAtlasiO35066
PRIDEiO35066

PTM databases

iPTMnetiO35066
PhosphoSitePlusiO35066

Expressioni

Gene expression databases

BgeeiENSMUSG00000020668 Expressed in 282 organ(s), highest expression level in nucleus of brain
CleanExiMM_KIF3C
ExpressionAtlasiO35066 baseline and differential
GenevisibleiO35066 MM

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3C.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200943, 12 interactors
ComplexPortaliCPX-3202 KIF3 complex variant AC
CPX-3205 KIF3 complex variant AC-KAP3
IntActiO35066, 13 interactors
STRINGi10090.ENSMUSP00000020999

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO35066
SMRiO35066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 367Kinesin motorPROSITE-ProRule annotationAdd BLAST358

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni633 – 793GlobularSequence analysisAdd BLAST161

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili378 – 632Sequence analysisAdd BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi440 – 443Poly-Asn4

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOVERGENiHBG052255
InParanoidiO35066
KOiK20197
OMAiCKSVEDM
OrthoDBiEOG091G03RO
TreeFamiTF105223

Family and domain databases

InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 2 hits
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O35066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA
60 70 80 90 100
PGELPKTFTF DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG
110 120 130 140 150
TGKTYTMQGT WVEPELRGVI PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ
160 170 180 190 200
EEIRDLLSKE PGKRLELKEN PETGVYIKDL SSFVTKNVKE IEHVMNLGNQ
210 220 230 240 250
ARAVGSTHMN EVSSRSHAIF VITVECSERG SDGQDHIRVG KLNLVDLAGS
260 270 280 290 300
ERQNKAGPNA AGGPATQPTA GGGSGSGSAS GSASSGERPK EASKINLSLS
310 320 330 340 350
ALGNVIAALA GNRSTHIPYR DSKLTRLLQD SLGGNAKTIM VATLGPASHS
360 370 380 390 400
YDESLSTLRF ANRAKNIKNK PRVNEDPKDT LLREFQEEIA RLKAQLEKKG
410 420 430 440 450
MLGKRPRRKS SRRKKAVSAP AGYPEGSVIE AWVAEEEDDN NNNHHPPQPI
460 470 480 490 500
LEAALEKNME NYLQDQKERL EEEKAAIQDD RSLVSEEKQK LLEEKEKMLE
510 520 530 540 550
DLRREQQATE LLAAKYKAME SKLLIGGRNI MDHTNEQQKM LELKRQEIAE
560 570 580 590 600
QKRREREMQQ EMLLRDEETM ELRGTYSSLQ QEVEVKTKKL KKLYAKLQAV
610 620 630 640 650
KAEIQDQHEE YIRVRQDLEE AQNEQTRELK LKYLIIENFI PPEEKNKIMN
660 670 680 690 700
RLFLDCEEEQ WRFQPLVPAG VNNSQMKKRP TSAVGYKRPI SQYARVAMAM
710 720 730 740 750
GSHPRYRAEN IMFLELDVSP PAIFEMEFSH DQEQDPRVLH MERLMRLDSF
760 770 780 790
LERPSTTKVR KSRSWCQSPQ RMPPPSTAHA SMTSVPLHPA TVVDHD
Length:796
Mass (Da):89,973
Last modified:July 27, 2011 - v3
Checksum:i5CC5A5EB12958166
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UT07Q3UT07_MOUSE
Kinesin-like protein KIF3C
Kif3c
278Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93V → I in BAA22393 (PubMed:15489334).Curated1
Sequence conflicti564L → V in AAC39965 (PubMed:9450952).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013116 mRNA Translation: AAC39965.1
AK147572 mRNA Translation: BAE28002.1
CH466623 Genomic DNA Translation: EDL01397.1
BC127063 mRNA Translation: AAI27064.1
AB001433 mRNA Translation: BAA22393.1
CCDSiCCDS25783.1
RefSeqiNP_032471.2, NM_008445.2
UniGeneiMm.415417
Mm.472456
Mm.7688

Genome annotation databases

EnsembliENSMUST00000020999; ENSMUSP00000020999; ENSMUSG00000020668
ENSMUST00000220210; ENSMUSP00000151286; ENSMUSG00000020668
GeneIDi16570
KEGGimmu:16570
UCSCiuc007mwm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013116 mRNA Translation: AAC39965.1
AK147572 mRNA Translation: BAE28002.1
CH466623 Genomic DNA Translation: EDL01397.1
BC127063 mRNA Translation: AAI27064.1
AB001433 mRNA Translation: BAA22393.1
CCDSiCCDS25783.1
RefSeqiNP_032471.2, NM_008445.2
UniGeneiMm.415417
Mm.472456
Mm.7688

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JVMX-ray1.57A/B374-402[»]
ProteinModelPortaliO35066
SMRiO35066
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200943, 12 interactors
ComplexPortaliCPX-3202 KIF3 complex variant AC
CPX-3205 KIF3 complex variant AC-KAP3
IntActiO35066, 13 interactors
STRINGi10090.ENSMUSP00000020999

PTM databases

iPTMnetiO35066
PhosphoSitePlusiO35066

Proteomic databases

EPDiO35066
MaxQBiO35066
PaxDbiO35066
PeptideAtlasiO35066
PRIDEiO35066

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020999; ENSMUSP00000020999; ENSMUSG00000020668
ENSMUST00000220210; ENSMUSP00000151286; ENSMUSG00000020668
GeneIDi16570
KEGGimmu:16570
UCSCiuc007mwm.1 mouse

Organism-specific databases

CTDi3797
MGIiMGI:107979 Kif3c

Phylogenomic databases

eggNOGiKOG0240 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOVERGENiHBG052255
InParanoidiO35066
KOiK20197
OMAiCKSVEDM
OrthoDBiEOG091G03RO
TreeFamiTF105223

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-5620924 Intraflagellar transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

PROiPR:O35066
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020668 Expressed in 282 organ(s), highest expression level in nucleus of brain
CleanExiMM_KIF3C
ExpressionAtlasiO35066 baseline and differential
GenevisibleiO35066 MM

Family and domain databases

InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 2 hits
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF3C_MOUSE
AccessioniPrimary (citable) accession number: O35066
Secondary accession number(s): O35229, Q3UH55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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