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UniProtKB - O34987 (PBUG_BACSU)
Protein
Guanine/hypoxanthine permease PbuG
Gene
pbuG
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Involved in the uptake of the purine bases hypoxanthine and guanine.
2 PublicationsGO - Molecular functioni
- purine nucleobase transmembrane transporter activity Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | BSUB:BSU06370-MONOMER |
Protein family/group databases
TCDBi | 2.A.40.7.2, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family |
Names & Taxonomyi
Protein namesi | Recommended name: Guanine/hypoxanthine permease PbuG |
Gene namesi | Name:pbuG Synonyms:yebB Ordered Locus Names:BSU06370 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 57 – 77 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 251 – 271 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 291 – 311 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 354 – 374 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 388 – 408 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 419 – 439 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Cells lacking this gene show normal growth on inosine as the purine source, normal hypoxanthine-guanine phosphoribosyltransferase activity, and are resistant to azaguanine.2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000375868 | 1 – 440 | Guanine/hypoxanthine permease PbuGAdd BLAST | 440 |
Proteomic databases
PaxDbi | O34987 |
PRIDEi | O34987 |
Expressioni
Inductioni
Expression is regulated by both purR and xptR regulons. Negatively regulated by hypoxanthine and guanine.2 Publications
Family & Domainsi
Sequence similaritiesi
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2252, Bacteria |
InParanoidi | O34987 |
OMAi | LYGMARF |
PhylomeDBi | O34987 |
Family and domain databases
InterProi | View protein in InterPro IPR045018, Azg-like IPR026033, Azg-like_bact_archaea IPR006043, NCS2 |
PANTHERi | PTHR43337, PTHR43337, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
PIRSFi | PIRSF005353, PbuG, 1 hit |
i Sequence
Sequence statusi: Complete.
O34987-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTFFQFDEL GTSYRNEIIG GLTTFLSMAY ILFVNPITLA LESVKDFPEA
60 70 80 90 100
LRIDQGAVFT ATALASAAGC ILMGLIARYP IAIAPGMGLN AFFAFSVVLG
110 120 130 140 150
MGISWQAALS GVFISGLIFV ALSLTGFREK IINAIPPELK LAVGAGIGLF
160 170 180 190 200
ITFVGLQGSG IITANPSTLV TIGNIHSGPV LLTIFGVIVT VILMVLRVNA
210 220 230 240 250
GVFIGMLLTA VAGMIFGLVP VPTQIIGSVP SLAPTFGQAW IHLPDIFSVQ
260 270 280 290 300
MLIVILTFLF VGFFDTAGTL VAVATQAGLM KENKLPRAGR ALLADSSSIV
310 320 330 340 350
IGAVLGTSTT TSYVESSSGV AAGARSGFAA IVTGILFLLA TFFSPLLSVV
360 370 380 390 400
TSNVTAPALI IVGALMVAPL GKIAWDKFEV AVPAFLTMIM MPLTYSIATG
410 420 430 440
IAIGFIFYPI TMVCKGKAKE VHPIMYGLFV VFILYFIFLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51115 Genomic DNA Translation: AAB62312.1 AL009126 Genomic DNA Translation: CAB12456.1 |
PIRi | F69791 |
RefSeqi | NP_388518.1, NC_000964.3 WP_003243780.1, NZ_JNCM01000032.1 |
Genome annotation databases
EnsemblBacteriai | CAB12456; CAB12456; BSU_06370 |
GeneIDi | 936043 |
KEGGi | bsu:BSU06370 |
PATRICi | fig|224308.179.peg.692 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51115 Genomic DNA Translation: AAB62312.1 AL009126 Genomic DNA Translation: CAB12456.1 |
PIRi | F69791 |
RefSeqi | NP_388518.1, NC_000964.3 WP_003243780.1, NZ_JNCM01000032.1 |
3D structure databases
SMRi | O34987 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU06370 |
Protein family/group databases
TCDBi | 2.A.40.7.2, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family |
Proteomic databases
PaxDbi | O34987 |
PRIDEi | O34987 |
Protocols and materials databases
DNASUi | 936043 |
Genome annotation databases
EnsemblBacteriai | CAB12456; CAB12456; BSU_06370 |
GeneIDi | 936043 |
KEGGi | bsu:BSU06370 |
PATRICi | fig|224308.179.peg.692 |
Phylogenomic databases
eggNOGi | COG2252, Bacteria |
InParanoidi | O34987 |
OMAi | LYGMARF |
PhylomeDBi | O34987 |
Enzyme and pathway databases
BioCyci | BSUB:BSU06370-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR045018, Azg-like IPR026033, Azg-like_bact_archaea IPR006043, NCS2 |
PANTHERi | PTHR43337, PTHR43337, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
PIRSFi | PIRSF005353, PbuG, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PBUG_BACSU | |
Accessioni | O34987Primary (citable) accession number: O34987 Secondary accession number(s): Q79C44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families