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UniProtKB - O34847 (ACCA_BACSU)
Protein
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Gene
accA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
UniRule annotationCatalytic activityi
- acetyl-CoA + N6-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N6-biotinyl-L-lysyl-[protein]UniRule annotationEC:2.1.3.15UniRule annotation
Activity regulationi
Inhibited by pyrrolidine dione antibiotics moiramide B (CPD1) and CPD2.1 Publication
: malonyl-CoA biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.
GO - Molecular functioni
- acetyl-CoA carboxylase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- carboxyl- or carbamoyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-UniRule
- malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Antibiotic resistance, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU29200-MONOMER |
UniPathwayi | UPA00655;UER00711 |
Names & Taxonomyi
Protein namesi | Recommended name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotation (EC:2.1.3.15UniRule annotation)Short name: ACCase subunit alphaUniRule annotation Short name: Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation |
Gene namesi | Name:accAUniRule annotation Ordered Locus Names:BSU29200 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- acetyl-CoA carboxylase complex Source: InterPro
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 199 | G → S: Resistant to the pyrrolidine dione antibiotic CPD2. 1 Publication | 1 | |
Mutagenesisi | 227 | E → K: Resistance to polyketide antibiotic thailandamide. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146773 | 1 – 325 | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaAdd BLAST | 325 |
Proteomic databases
PaxDbi | O34847 |
PRIDEi | O34847 |
Interactioni
Subunit structurei
Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
UniRule annotationProtein-protein interaction databases
STRINGi | 224308.BSU29200 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 292 | CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST | 255 |
Sequence similaritiesi
Belongs to the AccA family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0825, Bacteria |
InParanoidi | O34847 |
OMAi | TPWQRVQ |
PhylomeDBi | O34847 |
Family and domain databases
HAMAPi | MF_00823, AcetylCoA_CT_alpha, 1 hit |
InterProi | View protein in InterPro IPR001095, Acetyl_CoA_COase_a_su IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C |
PANTHERi | PTHR42853, PTHR42853, 1 hit |
Pfami | View protein in Pfam PF03255, ACCA, 1 hit |
PRINTSi | PR01069, ACCCTRFRASEA |
SUPFAMi | SSF52096, SSF52096, 1 hit |
TIGRFAMsi | TIGR00513, accA, 1 hit |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit |
i Sequence
Sequence statusi: Complete.
O34847-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPRLEFEKP VIELQTKIAE LKKFTQDSDM DLSAEIERLE DRLAKLQDDI
60 70 80 90 100
YKNLKPWDRV QIARLADRPT TLDYIEHLFT DFFECHGDRA YGDDEAIVGG
110 120 130 140 150
IAKFHGLPVT VIGHQRGKDT KENLVRNFGM PHPEGYRKAL RLMKQADKFN
160 170 180 190 200
RPIICFIDTK GAYPGRAAEE RGQSEAIAKN LFEMAGLRVP VICIVIGEGG
210 220 230 240 250
SGGALGLGVG NHLHMLENST YSVISPEGAA ALLWKDSSLA KKAAETMKIT
260 270 280 290 300
APDLKELGII DHMIKEVKGG AHHDVKLQAS YMDETLKQSL KTLLKLSEEE
310 320
LVQQRYEKYK AIGKVSVEDQ YIGVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF008220 Genomic DNA Translation: AAC00341.1 AL009126 Genomic DNA Translation: CAB14880.1 |
PIRi | G69580 |
RefSeqi | NP_390798.1, NC_000964.3 WP_003229417.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14880; CAB14880; BSU_29200 |
GeneIDi | 936367 |
KEGGi | bsu:BSU29200 |
PATRICi | fig|224308.179.peg.3171 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF008220 Genomic DNA Translation: AAC00341.1 AL009126 Genomic DNA Translation: CAB14880.1 |
PIRi | G69580 |
RefSeqi | NP_390798.1, NC_000964.3 WP_003229417.1, NZ_JNCM01000036.1 |
3D structure databases
AlphaFoldDBi | O34847 |
SMRi | O34847 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU29200 |
Proteomic databases
PaxDbi | O34847 |
PRIDEi | O34847 |
Protocols and materials databases
DNASUi | 936367 |
Genome annotation databases
EnsemblBacteriai | CAB14880; CAB14880; BSU_29200 |
GeneIDi | 936367 |
KEGGi | bsu:BSU29200 |
PATRICi | fig|224308.179.peg.3171 |
Phylogenomic databases
eggNOGi | COG0825, Bacteria |
InParanoidi | O34847 |
OMAi | TPWQRVQ |
PhylomeDBi | O34847 |
Enzyme and pathway databases
UniPathwayi | UPA00655;UER00711 |
BioCyci | BSUB:BSU29200-MONOMER |
Family and domain databases
HAMAPi | MF_00823, AcetylCoA_CT_alpha, 1 hit |
InterProi | View protein in InterPro IPR001095, Acetyl_CoA_COase_a_su IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C |
PANTHERi | PTHR42853, PTHR42853, 1 hit |
Pfami | View protein in Pfam PF03255, ACCA, 1 hit |
PRINTSi | PR01069, ACCCTRFRASEA |
SUPFAMi | SSF52096, SSF52096, 1 hit |
TIGRFAMsi | TIGR00513, accA, 1 hit |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACCA_BACSU | |
Accessioni | O34847Primary (citable) accession number: O34847 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families