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UniProtKB - O34739 (STET_BACSU)
Protein
Serine/threonine exchanger SteT
Gene
steT
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Exhibits an obligate exchange activity for serine, threonine and aromatic amino acids.
1 PublicationGO - Molecular functioni
- L-amino acid transmembrane transporter activity Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | BSUB:BSU12860-MONOMER |
Protein family/group databases
TCDBi | 2.A.3.8.12, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine exchanger SteT |
Gene namesi | Name:steT Synonyms:ykbA Ordered Locus Names:BSU12860 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 33 – 45 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 46 – 66 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 67 – 98 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 99 – 119 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 126 | ExtracellularSequence analysis | 7 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 148 – 151 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 152 – 172 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 173 – 193 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 194 – 214 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 215 – 230 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 252 – 269 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 270 – 290 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 291 – 327 | CytoplasmicSequence analysisAdd BLAST | 37 | |
Transmembranei | 328 – 348 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 349 – 352 | ExtracellularSequence analysis | 4 | |
Transmembranei | 353 – 373 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 374 – 388 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 389 – 409 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 410 – 411 | ExtracellularSequence analysis | 2 | |
Transmembranei | 412 – 432 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 433 – 438 | CytoplasmicSequence analysis | 6 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 94 | C → S: Retains 25% of the transport activity; when associated with S-141; S-168; S-291 and S-415. 1 Publication | 1 | |
Mutagenesisi | 141 | C → S: Retains 25% of the transport activity; when associated with S-94; S-168; S-291 and S-415. 1 Publication | 1 | |
Mutagenesisi | 168 | C → S: Retains 25% of the transport activity; when associated with S-94; S-141; S-291 and S-415. 1 Publication | 1 | |
Mutagenesisi | 291 | C → S: Retains 25% of the transport activity; when associated with S-94; S-141; S-168 and S-415. 1 Publication | 1 | |
Mutagenesisi | 415 | C → S: Retains 25% of the transport activity; when associated with S-94; S-141; S-168 and S-291. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000376828 | 1 – 438 | Serine/threonine exchanger SteTAdd BLAST | 438 |
Proteomic databases
PaxDbi | O34739 |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
STRINGi | 224308.BSU12860 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0531, Bacteria |
InParanoidi | O34739 |
OMAi | YDGWILI |
PhylomeDBi | O34739 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O34739-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHTEDNGLKK EIGLLFALTL VIGTIIGSGV FMKPGAVLAY SGDSKMALFA
60 70 80 90 100
WLLGGILTLA GGLTIAEIGT QIPKTGGLYT YLEEVYGEFW GFLCGWVQII
110 120 130 140 150
IYGPAIIGAL GLYFGSLMAN LFGWGSGLSK VIGIIAVLFL CVINIIGTKY
160 170 180 190 200
GGFVQTLTTI GKLIPIACII VFGLWKGDQH IFTAVNESIS DMNFGAAILA
210 220 230 240 250
TLFAYDGWIL LAALGGEMKN PEKLLPRAMT GGLLIVTAIY IFINFALLHI
260 270 280 290 300
LSANEIVTLG ENATSTAATM LFGSIGGKLI SVGIIVSIFG CLNGKVLSFP
310 320 330 340 350
RVSFAMAERK QLPFAEKLSH VHPSFRTPWI AISFQIALAL IMMLISNPDK
360 370 380 390 400
LSEISIFMIY IFYVMAFFAV FILRKRAKGE KRAYSVPLYP FMPILAIAGS
410 420 430
FFVLGSTLIT DTMSCGLSIL IGLAGLPVYY GMKKRKAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002571 Genomic DNA Translation: CAA05566.1 AL009126 Genomic DNA Translation: CAB13143.1 |
PIRi | B69855 |
RefSeqi | NP_389169.1, NC_000964.3 WP_003244819.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB13143; CAB13143; BSU_12860 |
GeneIDi | 936518 |
KEGGi | bsu:BSU12860 |
PATRICi | fig|224308.179.peg.1395 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ002571 Genomic DNA Translation: CAA05566.1 AL009126 Genomic DNA Translation: CAB13143.1 |
PIRi | B69855 |
RefSeqi | NP_389169.1, NC_000964.3 WP_003244819.1, NZ_JNCM01000035.1 |
3D structure databases
AlphaFoldDBi | O34739 |
SMRi | O34739 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU12860 |
Protein family/group databases
TCDBi | 2.A.3.8.12, the amino acid-polyamine-organocation (apc) family |
Proteomic databases
PaxDbi | O34739 |
Genome annotation databases
EnsemblBacteriai | CAB13143; CAB13143; BSU_12860 |
GeneIDi | 936518 |
KEGGi | bsu:BSU12860 |
PATRICi | fig|224308.179.peg.1395 |
Phylogenomic databases
eggNOGi | COG0531, Bacteria |
InParanoidi | O34739 |
OMAi | YDGWILI |
PhylomeDBi | O34739 |
Enzyme and pathway databases
BioCyci | BSUB:BSU12860-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STET_BACSU | |
Accessioni | O34739Primary (citable) accession number: O34739 Secondary accession number(s): Q7B3R0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families