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Entry version 120 (07 Apr 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Magnesium transporter MgtE

Gene

mgtE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a magnesium transporter.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi96Magnesium 1By similarity1
Metal bindingi216Magnesium 3By similarity1
Metal bindingi218Magnesium 4By similarity1
Metal bindingi228Magnesium 5By similarity1
Metal bindingi249Magnesium 1By similarity1
Metal bindingi257Magnesium 3By similarity1
Metal bindingi260Magnesium 3By similarity1
Metal bindingi261Magnesium 4By similarity1
Metal bindingi419Magnesium 4By similarity1
Metal bindingi433Magnesium 6By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU13300-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.26.1.3, the mg(2+) transporter-e (mgte) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Magnesium transporter MgtE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mgtE
Synonyms:ykoK
Ordered Locus Names:BSU13300
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 277CytoplasmicBy similarityAdd BLAST277
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei278 – 305Helical; Name=1By similarityAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei306 – 320By similarityAdd BLAST15
Transmembranei321 – 344Helical; Name=2By similarityAdd BLAST24
Topological domaini345 – 351CytoplasmicBy similarity7
Transmembranei352 – 382Helical; Name=3By similarityAdd BLAST31
Intramembranei383 – 386By similarity4
Transmembranei387 – 415Helical; Name=4By similarityAdd BLAST29
Intramembranei416 – 425By similarity10
Transmembranei426 – 448Helical; Name=5By similarityAdd BLAST23
Topological domaini449 – 451PeriplasmicBy similarity3

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003638871 – 451Magnesium transporter MgtEAdd BLAST451

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O34442

PRoteomics IDEntifications database

More...
PRIDEi
O34442

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU13300

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O34442

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini140 – 203CBS 1PROSITE-ProRule annotationAdd BLAST64
Domaini204 – 260CBS 2PROSITE-ProRule annotationAdd BLAST57

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2239, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O34442

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYYAYVT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O34442

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.357.20, 1 hit
1.25.60.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000644, CBS_dom
IPR006668, Mg_transptr_MgtE_intracell_dom
IPR038076, MgtE_N_sf
IPR038048, MgtE_transmem
IPR006669, MgtE_transporter
IPR006667, SLC41_membr_dom
IPR036739, SLC41_membr_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR43773, PTHR43773, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00571, CBS, 2 hits
PF01769, MgtE, 1 hit
PF03448, MgtE_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00116, CBS, 2 hits
SM00924, MgtE_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161093, SSF161093, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00400, mgtE, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51371, CBS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O34442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQNMTYDEL ILRIIILLRD GKIRDFRSVI DELQPYDMAF IFKEMPEKHR
60 70 80 90 100
ARYLSYLTVD DITDMIGELE REFQLVVLNK VGKTKATLAM NKMDNDDLAQ
110 120 130 140 150
LLEEMDEELK EQLLSSMEAS ESKAVQLLMN YPADSAGRMM TNRYVWIPQH
160 170 180 190 200
YTVKDAVVKL KSFAEIAESI NYLYVINESK QLVGVLSYRD LILGEPEEKV
210 220 230 240 250
QDLMFTRVIS ADALQDQEEV ARLIERYDFL AIPVVEENNV LVGIVTVDDI
260 270 280 290 300
IDVVIREADE DYEKFAASGK DITFDTKAYV AAYRRLPWLI LLLFIGLISG
310 320 330 340 350
SIISYFEDAL KQVVALAFFM PMVSGMTGNT GTQSLAVVIR GLSKEEMNKK
360 370 380 390 400
TIVRLIFREF RTSIFIGAVC SVLIAIVSII WQGNALLGFV VASSLFLTLI
410 420 430 440 450
IGTMSGTIIP IILHKLKVDP AIASGPLITT LNDILSLLIY FGIATAFIHS

L
Length:451
Mass (Da):50,844
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5103B96F03EA09C0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ002571 Genomic DNA Translation: CAA05608.1
AL009126 Genomic DNA Translation: CAB13187.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G69859

NCBI Reference Sequences

More...
RefSeqi
NP_389213.1, NC_000964.3
WP_003232543.1, NZ_JNCM01000035.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB13187; CAB13187; BSU_13300

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
936439

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU13300

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.1445

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002571 Genomic DNA Translation: CAA05608.1
AL009126 Genomic DNA Translation: CAB13187.1
PIRiG69859
RefSeqiNP_389213.1, NC_000964.3
WP_003232543.1, NZ_JNCM01000035.1

3D structure databases

SMRiO34442
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU13300

Protein family/group databases

TCDBi1.A.26.1.3, the mg(2+) transporter-e (mgte) family

Proteomic databases

PaxDbiO34442
PRIDEiO34442

Genome annotation databases

EnsemblBacteriaiCAB13187; CAB13187; BSU_13300
GeneIDi936439
KEGGibsu:BSU13300
PATRICifig|224308.179.peg.1445

Phylogenomic databases

eggNOGiCOG2239, Bacteria
InParanoidiO34442
OMAiIYYAYVT
PhylomeDBiO34442

Enzyme and pathway databases

BioCyciBSUB:BSU13300-MONOMER

Family and domain databases

Gene3Di1.10.357.20, 1 hit
1.25.60.10, 1 hit
InterProiView protein in InterPro
IPR000644, CBS_dom
IPR006668, Mg_transptr_MgtE_intracell_dom
IPR038076, MgtE_N_sf
IPR038048, MgtE_transmem
IPR006669, MgtE_transporter
IPR006667, SLC41_membr_dom
IPR036739, SLC41_membr_dom_sf
PANTHERiPTHR43773, PTHR43773, 1 hit
PfamiView protein in Pfam
PF00571, CBS, 2 hits
PF01769, MgtE, 1 hit
PF03448, MgtE_N, 1 hit
SMARTiView protein in SMART
SM00116, CBS, 2 hits
SM00924, MgtE_N, 1 hit
SUPFAMiSSF161093, SSF161093, 1 hit
TIGRFAMsiTIGR00400, mgtE, 1 hit
PROSITEiView protein in PROSITE
PS51371, CBS, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGTE_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O34442
Secondary accession number(s): Q796L4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: January 1, 1998
Last modified: April 7, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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