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Protein

Calcium-transporting ATPase

Gene

yloB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi279Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi280Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi282Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi284Calcium 2By similarity1
Active sitei3264-aspartylphosphate intermediateBy similarity1
Metal bindingi633MagnesiumBy similarity1
Metal bindingi637MagnesiumBy similarity1
Metal bindingi699Calcium 1By similarity1
Metal bindingi702Calcium 1By similarity1
Metal bindingi727Calcium 2By similarity1
Metal bindingi730Calcium 1By similarity1
Metal bindingi731Calcium 1By similarity1
Metal bindingi731Calcium 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU15650-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase (EC:3.6.3.8)
Alternative name(s):
Calcium pump
Gene namesi
Name:yloB
Ordered Locus Names:BSU15650
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicBy similarityAdd BLAST47
Transmembranei48 – 68Helical; Name=1By similarityAdd BLAST21
Topological domaini69 – 78ExtracellularBy similarity10
Transmembranei79 – 99Helical; Name=2By similarityAdd BLAST21
Topological domaini100 – 238CytoplasmicBy similarityAdd BLAST139
Transmembranei239 – 258Helical; Name=3By similarityAdd BLAST20
Topological domaini259 – 270ExtracellularBy similarityAdd BLAST12
Transmembranei271 – 288Helical; Name=4By similarityAdd BLAST18
Topological domaini289 – 688CytoplasmicBy similarityAdd BLAST400
Transmembranei689 – 708Helical; Name=5By similarityAdd BLAST20
Topological domaini709 – 718ExtracellularBy similarity10
Transmembranei719 – 739Helical; Name=6By similarityAdd BLAST21
Topological domaini740 – 759CytoplasmicBy similarityAdd BLAST20
Transmembranei760 – 782Helical; Name=7By similarityAdd BLAST23
Topological domaini783 – 798ExtracellularBy similarityAdd BLAST16
Transmembranei799 – 818Helical; Name=8By similarityAdd BLAST20
Topological domaini819 – 830CytoplasmicBy similarityAdd BLAST12
Transmembranei831 – 849Helical; Name=9By similarityAdd BLAST19
Topological domaini850 – 864ExtracellularBy similarityAdd BLAST15
Transmembranei865 – 885Helical; Name=10By similarityAdd BLAST21
Topological domaini886 – 890CytoplasmicBy similarity5

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Spores are less resistant to heat and germinate at a slower rate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003608511 – 890Calcium-transporting ATPaseAdd BLAST890

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO34431
PRIDEiO34431

Expressioni

Developmental stagei

Expressed from 4 hours and peaks at 9 hours after onset of sporulation.1 Publication

Interactioni

Protein-protein interaction databases

IntActiO34431, 1 interactor
STRINGi224308.Bsubs1_010100008646

Structurei

3D structure databases

ProteinModelPortaliO34431
SMRiO34431
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474 LUCA
HOGENOMiHOG000265621
InParanoidiO34431
KOiK01537
OMAiCRSESKS
PhylomeDBiO34431

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005782 P-type_ATPase_IIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01116 ATPase-IIA1_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

O34431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFHEMGQTD LLEATNTSMK QGLTEKEVKK RLDKHGPNEL QEGKKTSALL
60 70 80 90 100
LFFAQFKDFM VLVLLAATLI SGFLGEYVDA VAIIAIVFVN GILGFFQERR
110 120 130 140 150
AEQSLQALKE LSTPHVMALR EGSWTKIPSK ELVPGDIVKF TSGDRIGADV
160 170 180 190 200
RIVEARSLEI EESALTGESI PVVKHADKLK KPDVSLGDIT NMAFMGTIVT
210 220 230 240 250
RGSGVGVVVG TGMNTAMGKI ADMLESAGTL STPLQRRLEQ LGKILIVVAL
260 270 280 290 300
LLTVLVVAVG VIQGHDLYSM FLAGVSLAVA AIPEGLPAIV TVALSLGVQR
310 320 330 340 350
MIKQKSIVRK LPAVETLGCA SIICSDKTGT MTQNKMTVTH VWSGGKTWRV
360 370 380 390 400
AGAGYEPKGS FTLNEKEISV NEHKPLQQML LFGALCNNSN IEKRDGEYVL
410 420 430 440 450
DGDPTEGALL TAARKGGFSK EFVESNYRVI EEFPFDSARK MMTVIVENQD
460 470 480 490 500
RKRYIITKGA PDVLMQRSSR IYYDGSAALF SNERKAETEA VLRHLASQAL
510 520 530 540 550
RTIAVAYRPI KAGETPSMEQ AEKDLTMLGL SGIIDPPRPE VRQAIKECRE
560 570 580 590 600
AGIKTVMITG DHVETAKAIA KDLRLLPKSG KIMDGKMLNE LSQEELSHVV
610 620 630 640 650
EDVYVFARVS PEHKLKIVKA YQENGHIVAM TGDGVNDAPA IKQADIGVSM
660 670 680 690 700
GITGTDVAKE ASSLVLVDDN FATIKSAIKE GRNIYENIRK FIRYLLASNV
710 720 730 740 750
GEILVMLFAM LLALPLPLVP IQILWVNLVT DGLPAMALGM DQPEGDVMKR
760 770 780 790 800
KPRHPKEGVF ARKLGWKVVS RGFLIGVATI LAFIIVYHRN PENLAYAQTI
810 820 830 840 850
AFATLVLAQL IHVFDCRSET SVFSRNPFQN LYLIGAVLSS ILLMLVVIYY
860 870 880 890
PPLQPIFHTV AITPGDWMLV IGMSAIPTFL LAGSLLTRKK
Length:890
Mass (Da):97,293
Last modified:January 1, 1998 - v1
Checksum:i43CB25F7A9BA31A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13937 Genomic DNA Translation: CAA74269.1
AL009126 Genomic DNA Translation: CAB13439.1
PIRiH69877
RefSeqiNP_389448.1, NC_000964.3
WP_003232087.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13439; CAB13439; BSU15650
GeneIDi936954
KEGGibsu:BSU15650
PATRICifig|224308.179.peg.1705

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13937 Genomic DNA Translation: CAA74269.1
AL009126 Genomic DNA Translation: CAB13439.1
PIRiH69877
RefSeqiNP_389448.1, NC_000964.3
WP_003232087.1, NZ_JNCM01000035.1

3D structure databases

ProteinModelPortaliO34431
SMRiO34431
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO34431, 1 interactor
STRINGi224308.Bsubs1_010100008646

Proteomic databases

PaxDbiO34431
PRIDEiO34431

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13439; CAB13439; BSU15650
GeneIDi936954
KEGGibsu:BSU15650
PATRICifig|224308.179.peg.1705

Phylogenomic databases

eggNOGiCOG0474 LUCA
HOGENOMiHOG000265621
InParanoidiO34431
KOiK01537
OMAiCRSESKS
PhylomeDBiO34431

Enzyme and pathway databases

BioCyciBSUB:BSU15650-MONOMER

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005782 P-type_ATPase_IIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01116 ATPase-IIA1_Ca, 1 hit
TIGR01494 ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATCL_BACSU
AccessioniPrimary (citable) accession number: O34431
Secondary accession number(s): Q799L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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