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UniProtKB - O34349 (PGPB_BACSU)
Protein
Phosphatidylglycerophosphatase B
Gene
pgpB
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalyzes the dephosphorylation of phosphatidylglycerophosphate (PGP) to phosphatidylglycerol. Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate.
1 PublicationCatalytic activityi
- 1,2-diacyl-sn-glycero-3-phospho-(1ʼ-sn-glycero-3ʼ-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate1 PublicationEC:3.1.3.271 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 121 | Proton donors1 Publication | 1 | |
Active sitei | 171 | Nucleophile1 Publication | 1 | |
Sitei | 175 | Stabilizes the active site histidine for nucleophilic attack1 Publication | 1 |
GO - Molecular functioni
- phosphatidylglycerophosphatase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BioCyci | BSUB:BSU19650-MONOMER |
BRENDAi | 3.1.3.27, 658 |
Protein family/group databases
TCDBi | 9.B.105.2.3, the lead resistance fusion protein (pbrbc) family |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pgpB1 Publication Synonyms:yodM Ordered Locus Names:BSU19650 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 | Cytoplasmic1 Publication | 1 | |
Transmembranei | 2 – 17 | Helical1 PublicationAdd BLAST | 16 | |
Topological domaini | 18 – 55 | Extracellular1 PublicationAdd BLAST | 38 | |
Transmembranei | 56 – 74 | Helical1 PublicationAdd BLAST | 19 | |
Topological domaini | 75 – 78 | Cytoplasmic1 Publication | 4 | |
Transmembranei | 79 – 99 | Helical1 PublicationAdd BLAST | 21 | |
Topological domaini | 100 – 119 | Extracellular1 PublicationAdd BLAST | 20 | |
Transmembranei | 120 – 139 | Helical1 PublicationAdd BLAST | 20 | |
Topological domaini | 140 – 146 | Cytoplasmic1 Publication | 7 | |
Transmembranei | 147 – 167 | Helical1 PublicationAdd BLAST | 21 | |
Topological domaini | 168 – 172 | Extracellular1 Publication | 5 | |
Transmembranei | 173 – 196 | Helical1 PublicationAdd BLAST | 24 | |
Topological domaini | 197 – 203 | Cytoplasmic1 Publication | 7 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000359942 | 1 – 203 | Phosphatidylglycerophosphatase BAdd BLAST | 203 |
Proteomic databases
PaxDbi | O34349 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | O34349 |
SMRi | O34349 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 96 – 104 | Phosphatase sequence motif ICurated | 9 | |
Regioni | 118 – 121 | Phosphatase sequence motif IICurated | 4 | |
Regioni | 164 – 175 | Phosphatase sequence motif IIICuratedAdd BLAST | 12 |
Sequence similaritiesi
Belongs to the PA-phosphatase related phosphoesterase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0671, Bacteria |
InParanoidi | O34349 |
OMAi | VIWLWCK |
PhylomeDBi | O34349 |
Family and domain databases
InterProi | View protein in InterPro IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
i Sequence
Sequence statusi: Complete.
O34349-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYKPVSLFLF FLILAAAIHT NAVQSADEAI SKAAVLIRQP WLNEVMTGIT
60 70 80 90 100
HLGASSFLLP LIVIIGAGMF FYRKTWDGLL MLLVFGTDRL LNKVLKEWIE
110 120 130 140 150
RVRPDFAPLV HESSFSFPSG HSMNAACVYP VIAYFLVKHL PFLSKHKKMV
160 170 180 190 200
YIIAGVIAVL VGISRVYLGV HFVTDVLGGF SLGLLLFFLV KGFDEKIKRF
RQK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015775 Genomic DNA Translation: AAB72067.1 AL009126 Genomic DNA Translation: CAB13856.1 |
PIRi | H69903 |
RefSeqi | NP_389846.1, NC_000964.3 WP_004399336.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB13856; CAB13856; BSU_19650 |
GeneIDi | 940034 |
KEGGi | bsu:BSU19650 |
PATRICi | fig|224308.179.peg.2150 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015775 Genomic DNA Translation: AAB72067.1 AL009126 Genomic DNA Translation: CAB13856.1 |
PIRi | H69903 |
RefSeqi | NP_389846.1, NC_000964.3 WP_004399336.1, NZ_JNCM01000036.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5JKI | X-ray | 2.25 | A | 1-203 | [»] | |
6FMX | X-ray | 1.79 | A | 1-203 | [»] | |
AlphaFoldDBi | O34349 | |||||
SMRi | O34349 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU19650 |
Protein family/group databases
TCDBi | 9.B.105.2.3, the lead resistance fusion protein (pbrbc) family |
Proteomic databases
PaxDbi | O34349 |
Genome annotation databases
EnsemblBacteriai | CAB13856; CAB13856; BSU_19650 |
GeneIDi | 940034 |
KEGGi | bsu:BSU19650 |
PATRICi | fig|224308.179.peg.2150 |
Phylogenomic databases
eggNOGi | COG0671, Bacteria |
InParanoidi | O34349 |
OMAi | VIWLWCK |
PhylomeDBi | O34349 |
Enzyme and pathway databases
BioCyci | BSUB:BSU19650-MONOMER |
BRENDAi | 3.1.3.27, 658 |
Family and domain databases
InterProi | View protein in InterPro IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGPB_BACSU | |
Accessioni | O34349Primary (citable) accession number: O34349 Secondary accession number(s): Q796B5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 20, 2009 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families