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UniProtKB - O34340 (FABF_BACSU)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase 2
Gene
fabF
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Involved in the type II fatty acid elongation cycle (PubMed:11325930).
Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:11325930).
Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition (By similarity).
By similarity1 PublicationCatalytic activityi
- (9Z)-hexadecenoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]By similarityEC:2.3.1.179By similarity
Activity regulationi
Inhibited by cerulenin.1 Publication
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 164 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: GO_Central
GO - Biological processi
- fatty acid biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | BSUB:BSU11340-MONOMER |
UniPathwayi | UPA00094 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179By similarity)Alternative name(s): 3-oxoacyl-[acyl-carrier-protein] synthase II Beta-ketoacyl-ACP synthase II Short name: KAS II |
Gene namesi | Name:fabF1 Publication Synonyms:yjaY Ordered Locus Names:BSU11340 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000360846 | 1 – 413 | 3-oxoacyl-[acyl-carrier-protein] synthase 2Add BLAST | 413 |
Proteomic databases
jPOSTi | O34340 |
PaxDbi | O34340 |
PRIDEi | O34340 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O34340 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
InParanoidi | O34340 |
OMAi | YRYIKYK |
PhylomeDBi | O34340 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
O34340-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKKRVVVTG LGALSPLGND VDTSWNNAIN GVSGIGPITR VDAEEYPAKV
60 70 80 90 100
AAELKDFNVE DYMDKKEARK MDRFTQYAVV AAKMAVEDAD LNITDEIAPR
110 120 130 140 150
VGVWVGSGIG GLETLESQFE IFLTKGPRRV SPFFVPMMIP DMATGQISIA
160 170 180 190 200
LGAKGVNSCT VTACATGTNS IGDAFKVIQR GDADVMVTGG TEAPLTRMSF
210 220 230 240 250
AGFSANKALS TNPDPKTASR PFDKNRDGFV MGEGAGIIVL EELEHALARG
260 270 280 290 300
AKIYGEIVGY GSTGDAYHIT APAQDGEGGA RAMQEAIKDA GIAPEEIDYI
310 320 330 340 350
NAHGTSTYYN DKYETMAIKT VFGEHAHKLA VSSTKSMTGH LLGAAGGIEA
360 370 380 390 400
IFSILAIKEG VIPPTINIQT PDEECDLDYV PDEARRQELN YVLSNSLGFG
410
GHNATLIFKK YQS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 109 | I → F in strain: GS77; resistant to cerulenin. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB12975.1 |
PIRi | G69842 |
RefSeqi | NP_389016.1, NC_000964.3 WP_003244890.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB12975; CAB12975; BSU_11340 |
GeneIDi | 939803 |
KEGGi | bsu:BSU11340 |
PATRICi | fig|224308.179.peg.1219 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB12975.1 |
PIRi | G69842 |
RefSeqi | NP_389016.1, NC_000964.3 WP_003244890.1, NZ_JNCM01000035.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4LS5 | X-ray | 1.80 | A/B | 1-413 | [»] | |
4LS6 | X-ray | 1.56 | A/B | 1-413 | [»] | |
4LS7 | X-ray | 1.67 | A/B | 1-413 | [»] | |
4LS8 | X-ray | 2.10 | A/B | 1-413 | [»] | |
SMRi | O34340 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
MINTi | O34340 |
STRINGi | 224308.BSU11340 |
Proteomic databases
jPOSTi | O34340 |
PaxDbi | O34340 |
PRIDEi | O34340 |
Genome annotation databases
EnsemblBacteriai | CAB12975; CAB12975; BSU_11340 |
GeneIDi | 939803 |
KEGGi | bsu:BSU11340 |
PATRICi | fig|224308.179.peg.1219 |
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
InParanoidi | O34340 |
OMAi | YRYIKYK |
PhylomeDBi | O34340 |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
BioCyci | BSUB:BSU11340-MONOMER |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR017568, 3-oxoacyl-ACP_synth-2 IPR000794, Beta-ketoacyl_synthase IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
PIRSFi | PIRSF000447, KAS_II, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR03150, fabF, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABF_BACSU | |
Accessioni | O34340Primary (citable) accession number: O34340 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 20, 2009 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families