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UniProtKB - O34215 (GADH2_PANCY)
Protein
Gluconate 2-dehydrogenase cytochrome c subunit
Gene
N/A
Organism
Pantoea cypripedii (Pectobacterium cypripedii) (Erwinia cypripedii)
Status
Functioni
Part of the heterotrimer that catalyzes the conversion of D-gluconate to 2-dehydro-D-gluconate.
Catalytic activityi
- EC:1.1.99.3
Cofactori
pH dependencei
Optimum pH is 5.0.1 Publication
Temperature dependencei
Optimum temperature is 30 degrees Celsius.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 40 | Heme c 1; covalentPROSITE-ProRule annotation | 1 | |
Binding sitei | 43 | Heme c 1; covalentPROSITE-ProRule annotation | 1 | |
Metal bindingi | 44 | Iron (heme c 1 axial ligand)PROSITE-ProRule annotation | 1 | |
Binding sitei | 188 | Heme c 2; covalentPROSITE-ProRule annotation | 1 | |
Binding sitei | 191 | Heme c 2; covalentPROSITE-ProRule annotation | 1 | |
Metal bindingi | 192 | Iron (heme c 2 axial ligand)PROSITE-ProRule annotation | 1 | |
Binding sitei | 325 | Heme c 3; covalentPROSITE-ProRule annotation | 1 | |
Binding sitei | 328 | Heme c 3; covalentPROSITE-ProRule annotation | 1 | |
Metal bindingi | 329 | Iron (heme c 3 axial ligand)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- electron transfer activity Source: InterPro
- gluconate 2-dehydrogenase (acceptor) activity Source: UniProtKB-EC
- heme binding Source: InterPro
- iron ion binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Electron transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Gluconate 2-dehydrogenase cytochrome c subunit (EC:1.1.99.3)Short name: GA 2-DH cytochrome c subunit Short name: GADH cytochrome c subunit |
Organismi | Pantoea cypripedii (Pectobacterium cypripedii) (Erwinia cypripedii) |
Taxonomic identifieri | 55209 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Erwiniaceae › Pantoea |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Peripheral membrane protein Curated; Periplasmic side Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000045855 | 20 – 441 | Gluconate 2-dehydrogenase cytochrome c subunitAdd BLAST | 422 |
Post-translational modificationi
Binds 3 heme c groupd covalently per subunit.Curated
Interactioni
Subunit structurei
Heterotrimer.
Protein-protein interaction databases
STRINGi | 55209.HA50_01505 |
Structurei
3D structure databases
AlphaFoldDBi | O34215 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 129 | Cytochrome c 1PROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 173 – 289 | Cytochrome c 2PROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 312 – 403 | Cytochrome c 3PROSITE-ProRule annotationAdd BLAST | 92 |
Keywords - Domaini
Repeat, SignalFamily and domain databases
Gene3Di | 1.10.760.10, 3 hits |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR008168, Cyt_C_IC IPR014353, Membr-bd_ADH_cyt_c |
Pfami | View protein in Pfam PF00034, Cytochrom_C, 1 hit PF13442, Cytochrome_CBB3, 1 hit |
PIRSFi | PIRSF000018, Mb_ADH_cyt_c, 1 hit |
PRINTSi | PR00605, CYTCHROMECIC |
SUPFAMi | SSF46626, SSF46626, 3 hits |
PROSITEi | View protein in PROSITE PS51007, CYTC, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O34215-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMKSILALVL GTLSFAALAD DQANDALVKR GEYLARAGDC VACHSVKGGQ
60 70 80 90 100
PFAGGLPMAT PIGTIYSTNI TPDKTTGIGD YSYDDFQKAV RHGVAKNGDT
110 120 130 140 150
LYPAMPYPSY AVVSDEDMKA LYAYFMHGVA PVAQANKDSD IPWPLSMRWP
160 170 180 190 200
LAIWRGVFAP DVKAFQPAAQ EDPVLARGRY LVEGLGHCGA CHTPRSITMQ
210 220 230 240 250
EKALSNDGAH DYLSGSSAPI DGWTASNLRG DNRDGLGRWS EDDLRQFLRY
260 270 280 290 300
GRNDHTAAFG GMTDVVEHSL QHLSDDDITA IARYLKSLGA KDASQTVFTQ
310 320 330 340 350
DDQVAKALWK GDDSQTGASV YVDSCAACHK TDGSRLSALL PGAAWQPGGA
360 370 380 390 400
GEPDPTSLIH IVLTGGTLPG VQGAPTAITM PAFGWRLNDQ QVADVVNFIR
410 420 430 440
GSWGNGAKAT VTAKDVASLR KDETVQAHQG NADIKVLEQQ Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U97665 Genomic DNA Translation: AAC45884.1 |
PIRi | C38575 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U97665 Genomic DNA Translation: AAC45884.1 |
PIRi | C38575 |
3D structure databases
AlphaFoldDBi | O34215 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 55209.HA50_01505 |
Family and domain databases
Gene3Di | 1.10.760.10, 3 hits |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR008168, Cyt_C_IC IPR014353, Membr-bd_ADH_cyt_c |
Pfami | View protein in Pfam PF00034, Cytochrom_C, 1 hit PF13442, Cytochrome_CBB3, 1 hit |
PIRSFi | PIRSF000018, Mb_ADH_cyt_c, 1 hit |
PRINTSi | PR00605, CYTCHROMECIC |
SUPFAMi | SSF46626, SSF46626, 3 hits |
PROSITEi | View protein in PROSITE PS51007, CYTC, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GADH2_PANCY | |
Accessioni | O34215Primary (citable) accession number: O34215 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |