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Entry version 110 (11 Dec 2019)
Sequence version 1 (01 Jan 1998)
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Protein
Submitted name:

Tylactone synthase module 7

Gene

tylG

Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-18379

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
strfr-TYLG Thioesterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tylactone synthase module 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tylGImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces fradiae (Streptomyces roseoflavus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1906 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1487O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1452 – 1527CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni464 – 485DisorderedSequence analysisAdd BLAST22
Regioni1821 – 1841DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2 – 32Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K15988

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR041314 PikA4_N
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR020802 PKS_thioesterase
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR001031 Thioesterase
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF18605 PikAIV_N, 1 hit
PF00550 PP-binding, 1 hit
PF00975 Thioesterase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SM00824 PKS_TE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53474 SSF53474, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O33958-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMSAERLTE ALRTSLKEAE RLRRQNRELR AARDAAREPI AVVGMACRYP
60 70 80 90 100
GGVTGPEELW ELVAGGRDAI GPFPVDRGWD VASVYDPDPE SKGTTYCREG
110 120 130 140 150
GFLEGAGDFD AAFFGISPRE ALVMDPQQRL LLEVSWEALE RAGIDPSSLR
160 170 180 190 200
GSRGGVYVGA AHGSYASDPR LVPEGSEGYL LTGSADAVMS GRISYALGLE
210 220 230 240 250
GPSMTVETAC SSSLVALHLA VRALRHGECG LALAGGVAVM ADPAAFVEFS
260 270 280 290 300
RQKGLAADGR CKAFSAAADG TGWAEGVGVL VLERLSDARR AGHTVLGLVT
310 320 330 340 350
GTAVNQDGAS NGLTAPNGPA QQRVIAEALA DAGLSPEDVD AVEAHGTGTR
360 370 380 390 400
LGDPIEAGAL LAASGRNRSG DHPLWLGSLK SNIGHAQAAA GVGGVIKMLQ
410 420 430 440 450
ALRHGLLPRT LHADEPTPHA DWSSGRVRLL TSEVPWQRTG RPRRTGVSAF
460 470 480 490 500
GVGGTNAHVV LEEAPAPPAP EPAGEAPGGS RAAEGAEGPL AWVVSGRDEP
510 520 530 540 550
ALRSQARRLR DHLSRTPGAR PRDIAFSLAA TRAAFDHRAV LIGSDGAELA
560 570 580 590 600
AALDALAEGR DGPAVVRGVR DRDGRMAFLF TGQGSQRAGM AHDLHAAHTF
610 620 630 640 650
FASALDEVTD RLDPLLGRPL GALLDARPGS PEAALLDRTE YTQPALFAVE
660 670 680 690 700
VALHRLLEHW GMRPDLLLGH SVGELAAAHV AGVLDLDDAC ALVAARGRLM
710 720 730 740 750
QRLPPGGAMV SVRAGEDEVR ALLAGREDAV CVAAVNGPRS VVISGAEEAV
760 770 780 790 800
AEAAAQLAGR GRRTRRLRVA HAFHSPLMDG MLAGFREVAA GLRYREPELT
810 820 830 840 850
VVSTVTGRPA RPGELTGPDY WVAQVREPVR FADAVRTAHR LGARTFLETG
860 870 880 890 900
PDGVLCGMAE ECLEDDTVAL LPAIHKPGTA PHGPAAPGAL RAAAAAYGRG
910 920 930 940 950
ARVDWAGMHA DGPEGPARRV ELPVHAFRHR RYWLAPGRAA DTDDWMYRIG
960 970 980 990 1000
WDRLPAVTGG ARTAGRWLVI HPDSPRCREL SGHAERALRA AGASPVPLPV
1010 1020 1030 1040 1050
DAPAADRASF AALLRSATGP DTRGDTAAPV AGVLSLLSEE DRPHRQHAPV
1060 1070 1080 1090 1100
PAGVLATLSL MQAMEEEAVE ARVWCVSRAA VAAADRERPV GAGAALWGLG
1110 1120 1130 1140 1150
RVAALERPTR WGGLVDLPAS PGAAHWAAAV ERLAGPEDQI AVRASGSWGR
1160 1170 1180 1190 1200
RLTRLPRDGG GRTAAPAYRP RGTVLVTGGT GALGGHLARW LAAAGAEHLA
1210 1220 1230 1240 1250
LTSRRGPDAP GAAGLEAELL LLGAKVTFAA CDTADRDGLA RVLRAIPEDT
1260 1270 1280 1290 1300
PLTAVFHAAG VPQVTPLSRT SPEHFADVYA GKAAGAAHLD ELTRELGAGL
1310 1320 1330 1340 1350
DAFVLYSSGA GVWGSAGQGA YAAANAALDA LARRRAADGL PATSIAWGVW
1360 1370 1380 1390 1400
GGGGMGADEA GAEYLGRRGM RPMAPVSALR AMATAIASGE PCPTVTHTDW
1410 1420 1430 1440 1450
ERFGEGFTAF RPSPLIAGLG TPGGGRAAET PEEGNATAAA DLTALPPAEL
1460 1470 1480 1490 1500
RTALRELVRA RTAAALGLDD PAEVAEGERF PAMGFDSLAT VRLRRGLASA
1510 1520 1530 1540 1550
TGLDLPPDLL FDRDTPAALA AHLAELLATA RDHGPGGPGT GAAPADAGSG
1560 1570 1580 1590 1600
LPALYREAVR TGRAAEMAEL LAAASRFRPA FGTADRQPVA LVPLADGAED
1610 1620 1630 1640 1650
TGLPLLVGCA GTAVASGPVE FTAFAGALAD LPAAAPMAAL PQPGFLPGER
1660 1670 1680 1690 1700
VPATPEALFE AQAEALLRYA AGRPFVLLGH SAGANMAHAL TRHLEANGGG
1710 1720 1730 1740 1750
PAGLVLMDIY TPADPGAMGV WRNDMFQWVW RRSDIPPDDH RLTAMGAYHR
1760 1770 1780 1790 1800
LLLDWSPTPV RAPVLHLRAA EPMGDWPPGD TGWQSHWDGA HTTAGIPGNH
1810 1820 1830 1840
FTMMTEHASA AARLVHGWLA ERTPSGQGGS PSRAAGREER P
Length:1,841
Mass (Da):191,192
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B673FA388115051
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U78289 Genomic DNA Translation: AAB66508.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAB66508

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78289 Genomic DNA Translation: AAB66508.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

ESTHERistrfr-TYLG Thioesterase

Genome annotation databases

KEGGiag:AAB66508

Phylogenomic databases

KOiK15988

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18379

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR041314 PikA4_N
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR020802 PKS_thioesterase
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR001031 Thioesterase
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF18605 PikAIV_N, 1 hit
PF00550 PP-binding, 1 hit
PF00975 Thioesterase, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SM00824 PKS_TE, 1 hit
SUPFAMiSSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53474 SSF53474, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO33958_STRFR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O33958
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: December 11, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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