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Entry version 114 (11 Dec 2019)
Sequence version 1 (01 Jan 1998)
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Protein
Submitted name:

Tylactone synthase module 3

Gene

tylG

Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-18376

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tylactone synthase module 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tylGImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces fradiae (Streptomyces roseoflavus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1906 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1734O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1699 – 1774CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni852 – 875DisorderedSequence analysisAdd BLAST24
Regioni1824 – 1848DisorderedSequence analysisAdd BLAST25

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K15988

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 1 hit
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O33955-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAELVATRK RLGALEERAR EPIAVVAMSC RYPGGVTTPE DLWRLLADER
60 70 80 90 100
DAVSGLPRDR GWDLDALYDP DGGPGTSYAR EGGFLSHCAG FDAEFFGISP
110 120 130 140 150
REALAMDPQQ RLLLETSWEA LERAGVTADR ARGSRTGVYA GVMYDDYGAR
160 170 180 190 200
VLYGAGAGPP EDLEGYLVNG SAGSIASGRV SYTFGLRGPA VTVNTACSSS
210 220 230 240 250
LVSLHLAVRA LRNGECDMAL AGGATVLSTP TVLVDFSRQR GLAPDGRCKA
260 270 280 290 300
FADSADGTSW AEGAGMLLLQ RLSDARREGR PVLAVIRGSA VNQDGASNGL
310 320 330 340 350
TAPNGRAQRQ VIEDALRDAG VGPDQVDAVE AHGTGTELGD PIEAGALLAT
360 370 380 390 400
YGTARTAERP LWLGSLKSNI GHTQAAAGVA GVIKMVLAMR HGRLPRTLHV
410 420 430 440 450
DRPTTRVDWE KGGVRLLTEP VPWPGEAGEP RRAGVSSFGA SGTNAHVVLE
460 470 480 490 500
SVPAGEPPAA GRPEDTGGAW TVSGRGPAAL RAQAARLYDA LTGTGTGTGQ
510 520 530 540 550
GAGQGAGPGT AEVAGALAHA RTAFRHRAVV LGGNRAELLA GLRELAEEEH
560 570 580 590 600
PGPRVVTGTA PATERRTAFL FSGQGSQRAG SGRGLYRRHP VFARALDEVC
610 620 630 640 650
AALEPHLHRP LRDLMFAEPG SPEAEPLDRT EFTQPALFAL QTALFRLAEH
660 670 680 690 700
HGLRAEALCG HSVGEIAAAH AAGVLTLPDA ARLVAARGRL MQALPAGGAM
710 720 730 740 750
AALRATAEEI APLLERRAGE LALAAVNGPS SVVVSGDEAA VLELLEQWRA
760 770 780 790 800
EGREARRLAV SHAFHSPRMD GMLTQFDRVA RTLTFAPPTI PLVSTLTGTP
810 820 830 840 850
VTEETLCTAD HWVRQAREPV RFLDAMRTLR ADGIDTFVEL GPDGVLSAMA
860 870 880 890 900
RDCADDRPDG DTTGAGDGET PDPLLTLPLL RRSVPETGDA EHPGGFERAL
910 920 930 940 950
ATAYAHGVPL RLAPAPDAAS LAVAAELPTY AFQRTHYWLD APAAPAALPA
960 970 980 990 1000
GLDDAGHPLL SAALDLPGGR GTVWTGALSA ATLPWAADHS VHGRTVLPGT
1010 1020 1030 1040 1050
ALLDLALHAA PRVGELTFEA PLVLPEDGEV RLRVVLAEPD ASGVRELSVH
1060 1070 1080 1090 1100
SAGEDGGWTR HATAVLDTGT TTAGEPAGAP PAAWPPGDAE PLDLAAEYER
1110 1120 1130 1140 1150
FADAGIGYGP AFRGLRSAWR DGDAILADVR LPGELAGEAD RYGIHPALLD
1160 1170 1180 1190 1200
AALHTAAAAL GGAHGMLPFT WNGVTLHARG AHAIRVRLTP AGPDAVAVTA
1210 1220 1230 1240 1250
VDPAGRPVFT AASLTLRPVT TGQLTAAEAA RAPLYRVRWT GLPDTGTARD
1260 1270 1280 1290 1300
HTWAVAGGPG DLLPGETPHH PDLASALADT GTAPFRVLAD LRGYGTATPR
1310 1320 1330 1340 1350
ELASQALALV QQWADAAEAA EGRLVLVTRR AVDIGDGVTD PAAATVWGLV
1360 1370 1380 1390 1400
RAAQSEHPGC FALLDTDDSP RSRQLLPRVA GTAEQLALRD GTLLAPSLTR
1410 1420 1430 1440 1450
ATLPAGARLP ALDGTVLITG GTGSLGAEAA RHLVTRHGAR RLLLTSRSGP
1460 1470 1480 1490 1500
QAPGAAELVA ELAALGAHAD VAACDVADRA ALRALLDRVP AGHPLTAVLH
1510 1520 1530 1540 1550
TAGVLDDGVL TAQTPQRLAA VLRPKADAVR NLHELTQGHA LSAFILYSSA
1560 1570 1580 1590 1600
AGVLGSAGQS GYAAANAYLD SFAVWRRSRG LPAVSLGWGP WDGGGMASGL
1610 1620 1630 1640 1650
GGTDTARLRR SGIAPLSRAE GLAALDAALA AGGDDTAPAH LLPIRVDAVT
1660 1670 1680 1690 1700
LRGADTVPAV LRDLAGTAPS AAERPPGTPE DTNAPLADVT QLHGRERKEA
1710 1720 1730 1740 1750
LTGFVRAQVA AVLGHPTSDT IDVRRSFKEA GFDSLTAVEL RNRLRAATGL
1760 1770 1780 1790 1800
KLPATLVFDH PTPLALAGFL HRELPGAEAS LMSAIDTLRH RLRDALADDA
1810 1820 1830 1840 1850
ADDALRDQIT RRLETLLAGI ARTEEPAPAT AAADDGSGAG DVAERLSTAS
1860
DDELFELLDS GFTP
Length:1,864
Mass (Da):193,288
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64F99B82B9943C83
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U78289 Genomic DNA Translation: AAB66505.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAB66505

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78289 Genomic DNA Translation: AAB66505.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGiag:AAB66505

Phylogenomic databases

KOiK15988

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18376

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF00550 PP-binding, 1 hit
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF51735 SSF51735, 2 hits
SSF52151 SSF52151, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO33955_STRFR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O33955
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: December 11, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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