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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1837-MONOMER
UniPathwayi
UPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:ML1680
ORF Names:MLCB637.37c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1680

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986911 – 2162-phospho-L-lactate guanylyltransferaseAdd BLAST216

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1680

Structurei

3D structure databases

ProteinModelPortaliO33128
SMRiO33128
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0 Bacteria
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

O33128-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTRAGGTA DVGLIIAVKR LAAAKTRLGP VFSTRTRENV VLAMLVDTLT
60 70 80 90 100
AAAPVSALRS ITVITPDEAA AAAAAEFGAE ILADPTPDGH GDPLNNAIAA
110 120 130 140 150
AEHAIAGSFS NIVVLQGDLP ALQTQELSEA IAAARHHQRS FVADRLGSGT
160 170 180 190 200
AALCTFGTAL NPQFGPDSSA QHRRSGAIEL TGPWPGLRCD VDTPADLAAA
210
RRLGIGAATT RVVAHL
Length:216
Mass (Da):21,982
Last modified:January 1, 1998 - v1
Checksum:i5B6B30838C5AF8CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99263 Genomic DNA Translation: CAB16452.1
AL583923 Genomic DNA Translation: CAC30633.1
PIRiT45430
RefSeqiNP_302154.1, NC_002677.1
WP_010908475.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30633; CAC30633; CAC30633
GeneIDi910046
KEGGimle:ML1680
PATRICifig|272631.5.peg.3172

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99263 Genomic DNA Translation: CAB16452.1
AL583923 Genomic DNA Translation: CAC30633.1
PIRiT45430
RefSeqiNP_302154.1, NC_002677.1
WP_010908475.1, NC_002677.1

3D structure databases

ProteinModelPortaliO33128
SMRiO33128
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1680

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30633; CAC30633; CAC30633
GeneIDi910046
KEGGimle:ML1680
PATRICifig|272631.5.peg.3172

Organism-specific databases

LepromaiML1680

Phylogenomic databases

eggNOGiENOG4105ME0 Bacteria
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Enzyme and pathway databases

UniPathwayi
UPA00071

BioCyciMLEP272631:G1GT5-1837-MONOMER

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOFC_MYCLE
AccessioniPrimary (citable) accession number: O33128
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 1, 1998
Last modified: October 10, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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