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Protein

ESAT-6-like protein EsxB

Gene

esxB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

A secreted protein that might play a role in virulence. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA.By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processVirulence

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-56-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ESAT-6-like protein EsxB
Gene namesi
Name:esxB
Ordered Locus Names:ML0050
ORF Names:MLCB628.13c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0050

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001677952 – 100ESAT-6-like protein EsxBAdd BLAST99

Interactioni

Subunit structurei

Forms a tight 1:1 complex with EsxA (PubMed:20085764).1 Publication

Protein-protein interaction databases

IntActiO33084, 1 interactor
MINTiO33084
STRINGi272631.ML0050

Structurei

3D structure databases

ProteinModelPortaliO33084
SMRiO33084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the WXG100 family. CFP-10 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000073770
OMAiEISTKIW
OrthoDBiPOG091H2CTN

Family and domain databases

InterProiView protein in InterPro
IPR036689 ESAT-6-like_sf
IPR010310 T7SS_ESAT-6-like
PfamiView protein in Pfam
PF06013 WXG100, 1 hit
SUPFAMiSSF140453 SSF140453, 1 hit
TIGRFAMsiTIGR03930 WXG100_ESAT6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O33084-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEMITEAAI LTQQAAQFDQ IASGLSQERN FVDSIGQSFQ NTWEGQAASA
60 70 80 90 100
ALGALGRFDE AMQDQIRQLE SIVDKLNRSG GNYTKTDDEA NQLLSSKMNF
Length:100
Mass (Da):10,964
Last modified:January 23, 2007 - v3
Checksum:i460EE12F876EC383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14967 Genomic DNA Translation: CAA75210.1
AL583917 Genomic DNA Translation: CAC29558.1
PIRiT10032
RefSeqiNP_301163.1, NC_002677.1
WP_010907488.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC29558; CAC29558; CAC29558
GeneIDi910497
KEGGimle:ML0050
PATRICifig|272631.5.peg.73

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14967 Genomic DNA Translation: CAA75210.1
AL583917 Genomic DNA Translation: CAC29558.1
PIRiT10032
RefSeqiNP_301163.1, NC_002677.1
WP_010907488.1, NC_002677.1

3D structure databases

ProteinModelPortaliO33084
SMRiO33084
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO33084, 1 interactor
MINTiO33084
STRINGi272631.ML0050

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29558; CAC29558; CAC29558
GeneIDi910497
KEGGimle:ML0050
PATRICifig|272631.5.peg.73

Organism-specific databases

LepromaiML0050

Phylogenomic databases

HOGENOMiHOG000073770
OMAiEISTKIW
OrthoDBiPOG091H2CTN

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-56-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR036689 ESAT-6-like_sf
IPR010310 T7SS_ESAT-6-like
PfamiView protein in Pfam
PF06013 WXG100, 1 hit
SUPFAMiSSF140453 SSF140453, 1 hit
TIGRFAMsiTIGR03930 WXG100_ESAT6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESXB_MYCLE
AccessioniPrimary (citable) accession number: O33084
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 81 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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