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Protein

Proline iminopeptidase

Gene

pip

Organism
Serratia marcescens
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically catalyzes the removal of N-terminal proline residues from peptides.

Catalytic activityi

Release of N-terminal proline from a peptide.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113Nucleophile1
Active sitei2681
Active sitei296Proton donor1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.11.5 5690

Protein family/group databases

ESTHERiserma-impep Proline_iminopeptidase
MEROPSiS33.001

Names & Taxonomyi

Protein namesi
Recommended name:
Proline iminopeptidase (EC:3.4.11.5)
Short name:
PIP
Alternative name(s):
Prolyl aminopeptidase
Short name:
PAP
Gene namesi
Name:pip
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075256

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000808451 – 317Proline iminopeptidaseAdd BLAST317

Interactioni

Subunit structurei

Monomer.

Chemistry databases

BindingDBiO32449

Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO32449
SMRiO32449
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO32449

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 296AB hydrolase-1Sequence analysisAdd BLAST256

Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR002410 Peptidase_S33
IPR005944 Pro_iminopeptidase
PANTHERiPTHR43722 PTHR43722, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF006431 Pept_S33, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00793 PROAMNOPTASE
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR01249 pro_imino_pep_1, 1 hit

Sequencei

Sequence statusi: Complete.

O32449-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQLRGLYPP LAAYDSGWLD TGDGHRIYWE LSGNPNGKPA VFIHGGPGGG
60 70 80 90 100
ISPHHRQLFD PERYKVLLFD QRGCGRSRPH ASLDNNTTWH LVADIERLRE
110 120 130 140 150
MAGVEQWLVF GGSWGSTLAL AYAQTHPERV SEMVLRGIFT LRKQRLHWYY
160 170 180 190 200
QDGASRFFPE KWERVLSILS DDERKDVIAA YRQRLTSADP QVQLEAAKLW
210 220 230 240 250
SVWEGETVTL LPSRESASFG EDDFALAFAR IENHYFTHLG FLESDDQLLR
260 270 280 290 300
NVPLIRHIPA VIVHGRYDMA CQVQNAWDLA KAWPEAELHI VEGAGHSYDE
310
PGILHQLMIA TDRFAGK
Length:317
Mass (Da):36,084
Last modified:January 1, 1998 - v1
Checksum:i48A427C9B97D972D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87897 Genomic DNA Translation: BAA23336.1
PIRiJC5696

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87897 Genomic DNA Translation: BAA23336.1
PIRiJC5696

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QTRX-ray2.32A1-317[»]
1WM1X-ray2.10A1-317[»]
1X2BX-ray2.40A1-317[»]
1X2EX-ray2.40A1-317[»]
ProteinModelPortaliO32449
SMRiO32449
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiO32449
ChEMBLiCHEMBL1075256

Protein family/group databases

ESTHERiserma-impep Proline_iminopeptidase
MEROPSiS33.001

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.4.11.5 5690

Miscellaneous databases

EvolutionaryTraceiO32449

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR002410 Peptidase_S33
IPR005944 Pro_iminopeptidase
PANTHERiPTHR43722 PTHR43722, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF006431 Pept_S33, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00793 PROAMNOPTASE
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR01249 pro_imino_pep_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIP_SERMA
AccessioniPrimary (citable) accession number: O32449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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