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Entry version 135 (26 Feb 2020)
Sequence version 1 (01 Jan 1998)
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Protein
Submitted name:

Adenylate cyclase

Gene

cyaC

Organism
Arthrospira platensis (Spirulina platensis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1017CalciumCombined sources1
Metal bindingi1017Magnesium 1Combined sources1
Metal bindingi1017Magnesium 2Combined sources1
Metal bindingi1017Magnesium 3Combined sources1
Metal bindingi1018Calcium; via carbonyl oxygenCombined sources1
Metal bindingi1018Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi1059Magnesium 2; via carbonyl oxygenCombined sources1
Metal bindingi1061CalciumCombined sources1
Metal bindingi1061Magnesium 1Combined sources1
Metal bindingi1061Magnesium 2Combined sources1
Metal bindingi1061Magnesium 3Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseImported
LigandCalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.6.1.1 5828

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Adenylate cyclaseImported (EC:4.6.1.1Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cyaCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArthrospira platensis (Spirulina platensis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri118562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesMicrocoleaceaeArthrospira

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5755

Drug and drug target database

More...
DrugBanki
DB07706 2-Hydroxyestradiol
DB02355 Adenosine-5'-Rp-Alpha-Thio-Triphosphate
DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate

DrugCentral

More...
DrugCentrali
O32393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei604-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei8954-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O32393

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O32393

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O32393

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 126Response regulatoryInterPro annotationAdd BLAST116
Domaini283 – 327PHYTOCHROME_2InterPro annotationAdd BLAST45
Domaini569 – 783Histidine kinaseInterPro annotationAdd BLAST215
Domaini846 – 962Response regulatoryInterPro annotationAdd BLAST117
Domaini1012 – 1152Guanylate cyclaseInterPro annotationAdd BLAST141

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1083 – 1103Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105BZU Bacteria
ENOG410XNMH LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00082 HisKA, 1 hit
cd00156 REC, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.450.40, 2 hits
3.30.565.10, 1 hit
3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054 A/G_cyclase
IPR011006 CheY-like_superfamily
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR029787 Nucleotide_cyclase
IPR016132 Phyto_chromo_attachment
IPR004358 Sig_transdc_His_kin-like_C
IPR001789 Sig_transdc_resp-reg_receiver

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01590 GAF, 2 hits
PF00211 Guanylate_cyc, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF00072 Response_reg, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00344 BCTRLSENSOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044 CYCc, 1 hit
SM00065 GAF, 2 hits
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00448 REC, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 2 hits
SSF55073 SSF55073, 1 hit
SSF55874 SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50109 HIS_KIN, 1 hit
PS50046 PHYTOCHROME_2, 1 hit
PS50110 RESPONSE_REGULATORY, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O32393-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSPNRKLKP TILVVDDEPD NLDLLYRTFH REFKVLKAES GPAALKILEE
60 70 80 90 100
VGEVAVIISD QRMPYMSGTE FLSLTATQYP DSIRIILTGY TDVEDLVEAI
110 120 130 140 150
NSGKVFKYVT KPWKSDELKA IVQQGLETHN VLKSRTEELR LAQKQESLLY
160 170 180 190 200
EVTSTIRACP NSQEMLQRIV ETVGKMFEVS YCLLRSFGVG SDLIGLGAGV
210 220 230 240 250
SPTKQDITAT QGKEWFAYLA EGQNHQNSTT DNISVINNND LELRSLVWET
260 270 280 290 300
TEVMILSEGL GNDISDHDGP EWQQRRDVYQ RADIRSSLIV PLYYRQELLA
310 320 330 340 350
VLALHHTGSP RNWHEHEVQL AAGVADQAAL ALSQVRAYEQ VRELARREAL
360 370 380 390 400
VNTITNAIRS SLDPQKIFAA ITEQLGEALE VDGCALSLWS PGDEYMQCVG
410 420 430 440 450
LYNAAIKETV VETRPAALSE PDTSTTTNLP LLGVETNQSI ESDQSDDLPQ
460 470 480 490 500
SAAPISGNPV LQELIRTRAP VAIADIEQRP DSMVMLPLRS PSKALLVVPL
510 520 530 540 550
LLDGDIIGSI SLRQNHQVRH WQPSEIDMVL LVAAQAALAV QQARLYQKTR
560 570 580 590 600
QQAERLLEAD RLKTEFFQNV SHEFRTPLTL MIGPLETVVN QQQDLSLDQA
610 620 630 640 650
KIALRNSRRL LRLVNQLLDL QRFDAGRMQP SFRPCDLVEF CQQTVESFKS
660 670 680 690 700
YCDRKQINLV TNLQSCPQLY LDLERFDKVL YNLLSNAMKF TPTDGTITVS
710 720 730 740 750
LQPEGNYCRL MVKDTGIGIK QEQLPHLFER FRQAEGSANR SFEGSGLGLA
760 770 780 790 800
LVKELVELHH GRITVESEYG QGTTFTVWLQ MGNLHLPPSP LLDVPAEFDA
810 820 830 840 850
RRAAVELADV EVDLPDVQID DINLPEVLVA DGSASLTDHG QLGSNTVLVV
860 870 880 890 900
DDNPDLRRYV SMMLQNAGFN AVLAKNGADG FNKAQTYHPD VIVTDLMMPQ
910 920 930 940 950
VSGLELIRMI RSSPELRGTP IILLTAKADE DTRIEGVERG ADAYVSKPFN
960 970 980 990 1000
DRELIAEVRN LQALKAEERR VAHLNKYLTE SVLRRFLPES MVKKAAAGDL
1010 1020 1030 1040 1050
TLDLRPEPRL ITILFSDIVG FTRMSNALQS QGVAELLNEY LGEMTRAVFE
1060 1070 1080 1090 1100
NQGTVDKFVG DAIMALYGAP EEMSPSEQVR RAIATARQML VALEKLNQGW
1110 1120 1130 1140 1150
QERGLVGRNE VPPVRFRCGI HQGMAVVGLF GSQERSDFTA IGPSVNIAAR
1160 1170 1180 1190 1200
LQEATAPNSI MVSAMVAQYV PDEEIIKREF LELKGIDEPV MTCVINPNML

NQ
Length:1,202
Mass (Da):133,924
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i275BEC0C120AFD4D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D49692 Genomic DNA Translation: BAA22997.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T17197

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41381982

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49692 Genomic DNA Translation: BAA22997.1
PIRiT17197

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WC0X-ray2.40A/B1004-1202[»]
1WC1X-ray1.93A/B/C998-1202[»]
1WC3X-ray1.90A/B1004-1202[»]
1WC4X-ray3.00A/B1004-1202[»]
1WC5X-ray2.30A/B/C/D1004-1202[»]
1WC6X-ray2.51A/B/C998-1202[»]
2BW7X-ray2.30A/B/C/D1004-1202[»]
SMRiO32393
ModBaseiSearch...
PDBe-KBiSearch...

Chemistry databases

BindingDBiO32393
ChEMBLiCHEMBL5755
DrugBankiDB07706 2-Hydroxyestradiol
DB02355 Adenosine-5'-Rp-Alpha-Thio-Triphosphate
DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate
DrugCentraliO32393

Genome annotation databases

GeneIDi41381982

Phylogenomic databases

eggNOGiENOG4105BZU Bacteria
ENOG410XNMH LUCA

Enzyme and pathway databases

BRENDAi4.6.1.1 5828

Miscellaneous databases

EvolutionaryTraceiO32393

Family and domain databases

CDDicd00082 HisKA, 1 hit
cd00156 REC, 2 hits
Gene3Di3.30.450.40, 2 hits
3.30.565.10, 1 hit
3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR011006 CheY-like_superfamily
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR029787 Nucleotide_cyclase
IPR016132 Phyto_chromo_attachment
IPR004358 Sig_transdc_His_kin-like_C
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01590 GAF, 2 hits
PF00211 Guanylate_cyc, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF00072 Response_reg, 2 hits
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SM00065 GAF, 2 hits
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00448 REC, 2 hits
SUPFAMiSSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 2 hits
SSF55073 SSF55073, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50109 HIS_KIN, 1 hit
PS50046 PHYTOCHROME_2, 1 hit
PS50110 RESPONSE_REGULATORY, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO32393_ARTPT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O32393
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: February 26, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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