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UniProtKB - O32236 (RGHR_BACSU)
Protein
HTH-type transcriptional repressor RghR
Gene
rghR
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Represses the expression of yvaM and both rapG and rapH. Binds directly to the promoter regions of yvaM, rapG and rapH.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 19 – 38 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | BSUB:BSU33660-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional repressor RghRAlternative name(s): RapGH repressor |
Gene namesi | Name:rghR Synonyms:rghRA, yvaN Ordered Locus Names:BSU33660 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Cells lacking this gene display a derepression of rapG and rapH expression, which leads to a down-regulation of sfrA that in turn leads to the expression abolition of both comK and the late com operon comG.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000232704 | 1 – 135 | HTH-type transcriptional repressor RghRAdd BLAST | 135 |
Proteomic databases
PaxDbi | O32236 |
PRIDEi | O32236 |
Interactioni
Protein-protein interaction databases
IntActi | O32236, 1 interactor |
STRINGi | 224308.BSU33660 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 63 | HTH cro/C1-typePROSITE-ProRule annotationAdd BLAST | 56 |
Phylogenomic databases
eggNOGi | COG1396, Bacteria |
InParanoidi | O32236 |
OMAi | ERENWRH |
PhylomeDBi | O32236 |
Family and domain databases
CDDi | cd00093, HTH_XRE, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR001387, Cro/C1-type_HTH IPR010982, Lambda_DNA-bd_dom_sf IPR016759, RghR |
PIRSFi | PIRSF019364, RapGH_repressor, 1 hit |
SMARTi | View protein in SMART SM00530, HTH_XRE, 1 hit |
SUPFAMi | SSF47413, SSF47413, 1 hit |
PROSITEi | View protein in PROSITE PS50943, HTH_CROC1, 1 hit |
i Sequence
Sequence statusi: Complete.
O32236-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESFGEQLRA LREERKLTVN QLATYSGVSA AGISRIENGK RGVPKPATIK
60 70 80 90 100
KLAEALKIPY EGLMYKAGYI EEVHEARAPY ETKCKLLEKA EAYDLKNLAL
110 120 130
LENEKWQYLN KEDLLMLDHY FSFISDEAKK RSADD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09819 Genomic DNA Translation: AAB91590.1 AL009126 Genomic DNA Translation: CAB15371.1 |
PIRi | C70028 |
RefSeqi | NP_391246.1, NC_000964.3 WP_003220034.1, NZ_JNCM01000033.1 |
Genome annotation databases
EnsemblBacteriai | CAB15371; CAB15371; BSU_33660 |
GeneIDi | 64305127 936180 |
KEGGi | bsu:BSU33660 |
PATRICi | fig|224308.179.peg.3651 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09819 Genomic DNA Translation: AAB91590.1 AL009126 Genomic DNA Translation: CAB15371.1 |
PIRi | C70028 |
RefSeqi | NP_391246.1, NC_000964.3 WP_003220034.1, NZ_JNCM01000033.1 |
3D structure databases
SMRi | O32236 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O32236, 1 interactor |
STRINGi | 224308.BSU33660 |
Proteomic databases
PaxDbi | O32236 |
PRIDEi | O32236 |
Genome annotation databases
EnsemblBacteriai | CAB15371; CAB15371; BSU_33660 |
GeneIDi | 64305127 936180 |
KEGGi | bsu:BSU33660 |
PATRICi | fig|224308.179.peg.3651 |
Phylogenomic databases
eggNOGi | COG1396, Bacteria |
InParanoidi | O32236 |
OMAi | ERENWRH |
PhylomeDBi | O32236 |
Enzyme and pathway databases
BioCyci | BSUB:BSU33660-MONOMER |
Family and domain databases
CDDi | cd00093, HTH_XRE, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR001387, Cro/C1-type_HTH IPR010982, Lambda_DNA-bd_dom_sf IPR016759, RghR |
PIRSFi | PIRSF019364, RapGH_repressor, 1 hit |
SMARTi | View protein in SMART SM00530, HTH_XRE, 1 hit |
SUPFAMi | SSF47413, SSF47413, 1 hit |
PROSITEi | View protein in PROSITE PS50943, HTH_CROC1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RGHR_BACSU | |
Accessioni | O32236Primary (citable) accession number: O32236 Secondary accession number(s): Q79D98 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | January 1, 1998 | |
Last modified: | September 29, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |