We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O32217 (BDBC_BACSU)
Protein
Disulfide bond formation protein C
Gene
bdbC
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Required for the stabilization, possibly via formation of a disulfide bond, of the obligatory competence protein ComGC. Not normally required for production of the secreted lantibiotic sublancin 168, although it can partially substitute for BdbB when the latter is absent. It may also be required for the stability of other secreted proteins. Not required for sporulation.
2 PublicationsGO - Molecular functioni
- protein-disulfide reductase activity Source: UniProtKB-UniRule
GO - Biological processi
- establishment of competence for transformation Source: UniProtKB-KW
- protein folding Source: InterPro
Keywordsi
Molecular function | Chaperone, Oxidoreductase |
Biological process | Competence, Electron transport, Transport |
Enzyme and pathway databases
BioCyci | BSUB:BSU33470-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Disulfide bond formation protein CAlternative name(s): Disulfide oxidoreductase C Thiol-disulfide oxidoreductase C |
Gene namesi | Name:bdbC Synonyms:yvgU Ordered Locus Names:BSU33470 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Other locations
- Membrane raft 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.1 Publication
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 5 – 24 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 39 – 58 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 65 – 82 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 110 – 132 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Cells partially restore cytochrome c oxidase activity in a CcdA-deficient mutant, possibly because the bacteria can no longer oxidize the two heme-binding thiol groups in apocytochrome c.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059376 | 1 – 138 | Disulfide bond formation protein CAdd BLAST | 138 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 37 | Redox-activeBy similarity | ||
Disulfide bondi | 95 ↔ 101 | Redox-activeBy similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | O32217 |
Expressioni
Developmental stagei
A late competence gene, expression is enhanced in the presence of ComK.
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Redox-active center, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1495, Bacteria |
InParanoidi | O32217 |
OMAi | INWFGFI |
PhylomeDBi | O32217 |
Family and domain databases
Gene3Di | 1.20.1550.10, 1 hit |
HAMAPi | MF_00287, BdbC, 1 hit |
InterProi | View protein in InterPro IPR003752, DiS_bond_form_DsbB/BdbC IPR012187, Disulphide_bond_form_BdbC IPR023380, DsbB-like_sf |
PANTHERi | PTHR43469, PTHR43469, 1 hit |
Pfami | View protein in Pfam PF02600, DsbB, 1 hit |
PIRSFi | PIRSF036659, BdbC, 1 hit |
SUPFAMi | SSF158442, SSF158442, 1 hit |
i Sequence
Sequence statusi: Complete.
O32217-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNRIVFLYA SWVVALIAML GSLYFSEIRK FIPCELCWYQ RILMYPLVLI
60 70 80 90 100
LGIATFQGDT RVKKYVLPMA IIGAFISIMH YLEQKVPGFS GIKPCVSGVP
110 120 130
CSGQYINWFG FITIPFLALI AFILIIIFMC LLKGEKSE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB15352.1 |
PIRi | B70041 |
RefSeqi | NP_391227.1, NC_000964.3 WP_003228417.1, NZ_JNCM01000033.1 |
Genome annotation databases
EnsemblBacteriai | CAB15352; CAB15352; BSU_33470 |
GeneIDi | 936042 |
KEGGi | bsu:BSU33470 |
PATRICi | fig|224308.179.peg.3632 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB15352.1 |
PIRi | B70041 |
RefSeqi | NP_391227.1, NC_000964.3 WP_003228417.1, NZ_JNCM01000033.1 |
3D structure databases
SMRi | O32217 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU33470 |
Proteomic databases
PaxDbi | O32217 |
Genome annotation databases
EnsemblBacteriai | CAB15352; CAB15352; BSU_33470 |
GeneIDi | 936042 |
KEGGi | bsu:BSU33470 |
PATRICi | fig|224308.179.peg.3632 |
Phylogenomic databases
eggNOGi | COG1495, Bacteria |
InParanoidi | O32217 |
OMAi | INWFGFI |
PhylomeDBi | O32217 |
Enzyme and pathway databases
BioCyci | BSUB:BSU33470-MONOMER |
Family and domain databases
Gene3Di | 1.20.1550.10, 1 hit |
HAMAPi | MF_00287, BdbC, 1 hit |
InterProi | View protein in InterPro IPR003752, DiS_bond_form_DsbB/BdbC IPR012187, Disulphide_bond_form_BdbC IPR023380, DsbB-like_sf |
PANTHERi | PTHR43469, PTHR43469, 1 hit |
Pfami | View protein in Pfam PF02600, DsbB, 1 hit |
PIRSFi | PIRSF036659, BdbC, 1 hit |
SUPFAMi | SSF158442, SSF158442, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BDBC_BACSU | |
Accessioni | O32217Primary (citable) accession number: O32217 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families